Anxiolytic-like actions of anpirtoline in a mouse light-dark aversion paradigm.

abstract：:Familial Alzheimer's disease due to presenilin 1 (PSEN1) mutations shows considerable phenotypic variability with differences in neuropathology and neurological symptoms. Spastic paraparesis is a common neurological phenotype associated with Alzheimer's disease arising from PSEN1 mutations. To investigate whether know...

journal_title：Neuroreport

authors： Karlstrom H,Kwok JB,Gregory GC,Hallupp M,Brooks WS,Schofield PR

更新日期：2007-08-06 00:00:00

abstract：:Event-related potential studies have reported error-related negativity following both error commission and feedback indicating errors or monetary loss. The present study examined whether error-related negativities could be elicited by a predictive cue presented prior to both the decision and subsequent feedback in a g...

journal_title：Neuroreport

authors： Dunning JP,Hajcak G

更新日期：2007-11-19 00:00:00

abstract：:Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mec...

journal_title：Neuroreport

authors： Wei H,Pertovaara A

更新日期：1999-09-29 00:00:00

abstract：:The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...

journal_title：Neuroreport

authors： Kabeya K,Ishikawa K,Katakai K,Watanabe M,Ohe Y,Wakabayashi K,Mori M

更新日期：1998-03-30 00:00:00

abstract：:A tritiated specific and highly potent 5-HT4 antagonist: [3H]-GR113808 was used to label specific binding sites in human brain and for comparison in guinea-pig brain. [3H]-GR113808 association and dissociation were rapid, the binding was saturable and displaced by various serotoninergic agents with an affinity corresp...

journal_title：Neuroreport

authors： Waeber C,Sebben M,Grossman C,Javoy-Agid F,Bockaert J,Dumuis A

更新日期：1993-09-10 00:00:00

abstract：:NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...

journal_title：Neuroreport

authors： Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

更新日期：2000-08-03 00:00:00

abstract：:Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...

journal_title：Neuroreport

authors： Liu Y,Dou K,Wang Y,Li J

更新日期：2015-11-11 00:00:00

abstract：:To investigate the possibility that insulin-stimulated glucose uptake in C6 cells is due to transactivation of a G protein-mediated pathway, the role of Gq alpha in insulin signaling was studied. Insulin stimulation of [3H]2-deoxy-D-glucose (2DG) uptake by C6 cells was time- and concentration-dependent: at a concentra...

journal_title：Neuroreport

authors： Singh SP,Gao Y,Kunapuli SP,Ravindra R

更新日期：1997-07-07 00:00:00

abstract：:Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Activation of calpain has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function. We report here that preincubation of thin (10 micr...

journal_title：Neuroreport

authors： Bi X,Tocco G,Baudry M

更新日期：1994-12-30 00:00:00

abstract：:A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...

journal_title：Neuroreport

authors： Johnson RD,Hubscher CH

更新日期：2000-02-07 00:00:00

abstract：:The evaluative processing of the valence of action feedback is reflected by an event-related brain potential component called feedback-related negativity (FRN) or reward positivity (RewP). Recent studies have shown that FRN/RewP is markedly reduced when the action-feedback interval is long (e.g. 6000 ms), indicating t...

journal_title：Neuroreport

authors： Kimura K,Kimura M

更新日期：2016-09-28 00:00:00

abstract：:In neonatal retinal explants cultured long-term green cones are missing. Recently it was reported that thyroid hormone beta2 receptors (TR-beta2) are essential for these green cones to differentiate. Therefore transcript level of these receptors was investigated in our mouse retinal explants. However, thyroid receptor...

journal_title：Neuroreport

authors： Azadi S,Zhang Y,Caffé AR,Holmqvist B,van Veen T

更新日期：2002-05-07 00:00:00

abstract：:We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...

journal_title：Neuroreport

authors： Shim YJ,Shin YJ,Jeong SY,Kang SW,Kim BM,Park IS,Min BH

更新日期：2009-03-04 00:00:00

abstract：:Neurons of the vertebrate retina possess receptors for many neurotransmitters. Particularly interesting is a new type of GABA receptor (GABA rho) that, in contrast to GABAA and GABAB receptors, shows very little desensitization, is not blocked by bicuculline, and is not activated by baclofen. Homomeric human GABA rho ...

journal_title：Neuroreport

authors： Calvo DJ,Miledi R

更新日期：1995-05-30 00:00:00

abstract：:We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmo...

journal_title：Neuroreport

authors： Rusovan A,Kanje M

更新日期：1992-09-01 00:00:00

abstract：:In the anaesthetized rat, low frequency electrical stimulation of the Zusanli acupoint (S36) or noxious thermal stimulation caused by immersing the footpad in water at 52 degrees C caused marked expression of c-fos in the anterior lobe of the pituitary gland, as well as in the arcuate and some nearby hypothalamic nucl...

journal_title：Neuroreport

authors： Pan B,Castro-Lopes JM,Coimbra A

更新日期：1994-08-15 00:00:00

abstract：:We examined the electrophysiological correlates of the processing of social exclusion and inclusion by using a modified version of the Cyberball paradigm. Exclusion was found to be associated with a significant increase in the P3 complex. The frontal-central P3a was primarily related to the affective processing of rej...

journal_title：Neuroreport

authors： Gutz L,Küpper C,Renneberg B,Niedeggen M

更新日期：2011-06-22 00:00:00

abstract：:The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-de...

journal_title：Neuroreport

authors： Dubray C,Alloui A,Bardin L,Rock E,Mazur A,Rayssiguier Y,Eschalier A,Lavarenne J

更新日期：1997-04-14 00:00:00

abstract：:Face processing deficits are characteristic of autism spectrum conditions. However, event-related potential studies of autism spectrum conditions have found inconsistent results for the face selective N170 component. In this study, 15 adult males with autism spectrum conditions and 15 matched, typically developing con...

journal_title：Neuroreport

authors： Churches O,Wheelwright S,Baron-Cohen S,Ring H

更新日期：2010-04-21 00:00:00

abstract：:The aim of this study was to investigate whether frontal lobe damage affects thalamic volume in humans. Ipsilateral and contralateral thalamic areas were measured in 0.5T T1-weighted sagittal magnetic resonance images in 12 patients, first at the time of their surgery for relief of a unilateral frontal lobe brain tumo...

journal_title：Neuroreport

authors： Hulshoff Pol HE,van der Flier WM,Schnack HG,Tulleken CA,Ramos LM,van Ree JM,Kahn RS

更新日期：2000-09-11 00:00:00

abstract：:Experimental animals and patients are immobilized to allow continuous monitoring of physiological parameters. Restraint stress affects brain neurotransmitter levels and induces expression of immediate early genes. Whether immobilization stress affects outcomes in newborn animals which have suffered a hypoxic-ischaemic...

journal_title：Neuroreport

authors： Thoresen M,Bågenholm R,Løberg EM,Apriccna F

更新日期：1996-01-31 00:00:00

abstract：:Both extracellular guanosine and adenosine stimulated astrocyte proliferation in vitro and increased intracellular cAMP 6-fold within 2 min. The effects of both guanosine and adenosine on proliferation and cAMP levels were inhibited by antagonists of adenosine A2 receptors but augmented by A1 receptor antagonists. The...

journal_title：Neuroreport

authors： Rathbone MP,Middlemiss PJ,DeLuca B,Jovetich M

更新日期：1991-11-01 00:00:00

abstract：:As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...

journal_title：Neuroreport

authors： Michalski D,Härtig W,Krueger M,Hobohm C,Käs JA,Fuhs T

更新日期：2015-07-08 00:00:00

abstract：:As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...

journal_title：Neuroreport

authors： Sanchez-Alavez M,Criado JR,Klein I,Moroncini G,Conti B

更新日期：2008-10-08 00:00:00

abstract：:Regulation of CNTF mRNA was investigated in primary cortical astrocytes cultured from newborn rats and in C6 glioma cells. Northern blot analysis indicated that semi-confluent astrocyte cell cultures. CNTF added to confluent astrocyte cultures down-regulated CNTF message in a dose-dependent fashion. In contrast, when ...

journal_title：Neuroreport

authors： Meyer V,Unsicker K

更新日期：1994-10-03 00:00:00

abstract：:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

journal_title：Neuroreport

authors： Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

更新日期：1997-11-10 00:00:00

abstract：:Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...

journal_title：Neuroreport

authors： Banz BC,Wu J,Camenga DR,Mayes LC,Crowley MJ,Vaca FE

更新日期：2020-05-22 00:00:00

abstract：:The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in...

journal_title：Neuroreport

authors： Mukherjee D,Kaushik MK,Jaryal AK,Kumar VM,Mallick HN

更新日期：2012-05-09 00:00:00

abstract：:We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...

journal_title：Neuroreport

authors： Tashiro K,Hasegawa M,Ihara Y,Iwatsubo T

更新日期：1997-08-18 00:00:00

abstract：:As the most numerous cell type in the brain, astrocytes are coupled via gap junction channels. It is believed that communication among astrocytes is normally regulated by extracellular ions, neurotransmitters and neuromodulators. However, the level of astrocytic coupling is altered in abnormal conditions such as strok...

journal_title：Neuroreport

authors： Bani-Yaghoub M,Felker JM,Naus CC

更新日期：1999-12-16 00:00:00