Prostaglandin-D-synthase (beta-trace protein) levels in rat cerebrospinal fluid.

Abstract:

:The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the highest value of 66 +/- 8 microg/ml at 7 days after birth. No significant difference in the levels was seen between different times of day. Subcutaneous injections of all-trans retinoic acid caused a dramatic decrease in the protein levels in a dose- and time-dependent manner. These findings may raise the possibility that prostaglandin-D-synthase in CSF is involved in retinoic acid action on the brain.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kabeya K,Ishikawa K,Katakai K,Watanabe M,Ohe Y,Wakabayashi K,Mori M

doi

10.1097/00001756-199803300-00028

subject

Has Abstract

pub_date

1998-03-30 00:00:00

pages

915-9

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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