Abstract:
:Nerve growth factor (NGF) is trophic to sensory and sympathetic fibres, and ciliary neurotrophic factor (CNTF) to motoneurones, in animal models of peripheral nerve injury: NGF excess produces hyperalgesia. In this first study of injured human nerves and sensory ganglia, we quantified and localized endogenous NGF and CNTF in 59 neonate and adult patients with brachial plexus and peripheral nerve injury. NGF levels were generally depleted in injured nerves, but relatively preserved acutely in nerve segments distal to injury. NGF immunostaining was observed in Schwann cells in distal nerve segments with pockets of high levels in some neuromas. CNTF levels and immunostaining in Schwann cells were markedly decreased distally within days of injury. We propose that early local administration of NGF and CNTF-like agents may help prevent degenerative changes in injured nerves, while at later stages local anti-NGF treatment (e.g. of some neuromas) may ameliorate chronic pain.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Anand P,Terenghi G,Birch R,Wellmer A,Cedarbaum JM,Lindsay RM,Williams-Chestnut RE,Sinicropi DVdoi
10.1097/00001756-199705260-00028subject
Has Abstractpub_date
1997-05-27 00:00:00pages
1935-8issue
8eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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