Abstract:
:Results from a computer model of a thalamic network predict that agents augmenting GABA(A)-mediated inhibition in the reticular thalamic (RE) nucleus will be antiepileptic or desynchronizing. This provides support for the hypothesis that antiepileptics like benzodiazepines may exert their effects through an isolated increase of inhibition in the RE nucleus. When desynchronized, the model thalamocortical neurons showed a decreased probability of firing a low threshold spike, a decreased secondary inhibitory postsynaptic potential and a higher frequency of oscillations. The transition to desynchrony was also accompanied by an increased frequency in the firing of the model RE neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Thomas E,Lytton WWdoi
10.1097/00001756-199803090-00024subject
Has Abstractpub_date
1998-03-09 00:00:00pages
691-6issue
4eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Matrix metalloproteinases (MMPs) may contribute to tissue damage after cerebral ischemia. In this study, wildtype and MMP-2 knockout mice were subjected to permanent and transient (2 h) occlusions of the middle cerebral artery. Gelatin zymography showed that MMP-9 levels were increased in all brains after ischemia. MM...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00050
更新日期:2001-09-17 00:00:00
abstract::We show that the pro-apoptotic proteins Bax and Bak trigger apoptosis when over-expressed in sympathetic neurons cultured in the presence of NGF. This effect can be blocked with z-VAD-fmk, a peptide inhibitor of caspases, but not with anti-apoptotic chemical compounds such as antioxidants or proteasome inhibitors. The...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801050-00004
更新日期:1998-01-05 00:00:00
abstract::We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199709080-00012
更新日期:1997-09-08 00:00:00
abstract::We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00005
更新日期:1997-12-01 00:00:00
abstract::TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00016
更新日期:2001-10-29 00:00:00
abstract::The effect of chronic treatment with vitamin E (VE) on acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, as assessed by striatal dopamine (DA) depletion, was studied. Male C57B1/6J mice were fed VE (48 mg kg-1 per day, intragastric) for 4, 8, or 12 weeks prior to administration of MPTP (...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199109000-00012
更新日期:1991-09-01 00:00:00
abstract::Based on the results of recent in vitro studies, tau has been proposed to be involved in regulating signal transduction through the phospholipase C-gamma (PLC-gamma) signaling pathway. The present study provides support for the physiological relevance of this hypothesis by demonstrating the existence of a tau-PLC-gamm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801050-00014
更新日期:1998-01-05 00:00:00
abstract::A number of epidemiological studies suggest that estrogen therapy is linked to a reduced risk of developing Alzheimer's disease (AD). The present study was conducted to evaluate the effect of 17beta-estradiol on beta-amyloid (Abeta)-induced toxicity and was performed in rat pheochromocytoma PC 12 cells by measuring th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00004
更新日期:1999-11-26 00:00:00
abstract::Participation of the neuronal nicotinic receptor subunit alpha6 in a physiologically relevant receptor has yet to be demonstrated, but its high degree of expression in catecholaminergic nuclei has attracted considerable interest. To investigate the pattern of expression of the alpha6 protein, a subunit specific antibo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00019
更新日期:1997-08-18 00:00:00
abstract::Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199304000-00018
更新日期:1993-04-01 00:00:00
abstract::To determine whether physical match between studied and tested items influences blood flow increases in the hippocampal formation associated with recognition memory, positron emission tomography (PET) was used to measure changes in regional cerebral blood flow while healthy volunteers made old/new judgements about lin...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199712220-00028
更新日期:1997-12-22 00:00:00
abstract::Although beta-amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000127140.54853.04
更新日期:2004-06-07 00:00:00
abstract::Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834558df
更新日期:2011-03-30 00:00:00
abstract::The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00042
更新日期:1997-11-10 00:00:00
abstract::The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00013
更新日期:1993-12-13 00:00:00
abstract::This study examined 'prepulse inhibition' in the context of an auditory two-tone discrimination task performed by 15 healthy subjects. In order to distinguish between masking or excitatory information processes, weak acoustic pulses immediately preceded or succeeded a target or non-target tone in the discrimination. B...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199601310-00065
更新日期:1996-01-31 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328304d9ac
更新日期:2008-07-02 00:00:00
abstract::The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00019
更新日期:2000-04-07 00:00:00
abstract::Autophosphorylation of the alpha-isoform of Ca2+/calmodulin-dependent kinase II switches the kinase into an autonomous activity mode. This molecular switch is important for hippocampal long-term memory formation, which requires de novo gene transcription and protein synthesis. Here, we have studied whether auto-phosph...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000175244.51084.bb
更新日期:2005-08-22 00:00:00
abstract::Episodic memory for simple commands is better following enacted than verbal encoding. This has been proposed to be due to the possibility to base retrieval on motor information. Here we used PET to test the hypothesis that motor brain areas show increased retrieval-related activity following enacted compared to verbal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00027
更新日期:2000-07-14 00:00:00
abstract::The possible role of endogenous cholinergic innervation in hippocampal plasticity is controversial. We studied the role of acetylcholine (ACh) in short- and long-term potentiation (STP and LTP), using the cholinergic neurotoxin 192 IgG-saporin. It was still possible to induce STP the LTP in the CA1 field following com...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199603220-00024
更新日期:1996-03-22 00:00:00
abstract::This study investigated whether neural mechanisms of self-face recognition are modulated by attention by recording event-related brain potentials associated with self-face recognition. Participants identified head orientations of self-faces and familiar or unfamiliar other faces presented briefly at the center of the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203357.65190.61
更新日期:2006-03-20 00:00:00
abstract::Parturition plays a critical role in the full expression of maternal behavior in postpartum females, yet the precise mechanism remains unclear. Here we examined the role of parturition in the activation of Fos and FosB in the central oxytocin receptor (OTR) system in rats. Although expression of FosB, not Fos, was see...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308060-00007
更新日期:2003-08-06 00:00:00
abstract::This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cort...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199709290-00017
更新日期:1997-09-29 00:00:00
abstract::Bilabial, alveolar and velar sounds are produced at different locations around the oral cavity. fMRI was used to localize cortical representation of articulation in seven healthy subjects during repetitive lip and vertical tongue movements as well as repetitive articulation of /pa/ (bilabial), /ta/ (alveolar), /ka/ (v...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009110-00032
更新日期:2000-09-11 00:00:00
abstract:OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001582
更新日期:2021-01-18 00:00:00
abstract::We compared various measures of visual-vestibular interaction in subjects with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Subjects with IDDM exhibited significantly greater postural sway than controls on those conditions in the Clini...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002280-00012
更新日期:2000-02-28 00:00:00
abstract::Older adults are known to gain more than younger adults from the simultaneous presentation of semantically congruent sensory stimuli. Although these findings are quite exciting, they may not solely be due to age-related differences in multisensory processing. Rather, enhanced integration may be explained by alteration...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281e72ae7
更新日期:2007-07-02 00:00:00
abstract::The regional distribution of c-Fos expression in the brain after the administration of two tremorgenic agents was studied. In both the harmaline- and oxotremorin-treated rats, c-Fos-positive neurons were extensively distributed in the basal ganglia nuclei and the cerebellum. Additionally, in the harmaline-treated rats...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008030-00010
更新日期:2000-08-03 00:00:00
abstract::High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocyst...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000215777.99473.52
更新日期:2006-05-15 00:00:00