beta-N-methylamino-L-alanine is a low-affinity agonist of metabotropic glutamate receptors.

abstract：:An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...

journal_title：Neuroreport

authors： Li HY,Wang LL,Yeh RS

更新日期：1999-02-05 00:00:00

abstract：:The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis. We measured...

journal_title：Neuroreport

authors： Gatta LB,Albertini A,Ravid R,Finazzi D

更新日期：2002-11-15 00:00:00

abstract：:Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

journal_title：Neuroreport

authors： Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

更新日期：2008-07-16 00:00:00

abstract：:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

journal_title：Neuroreport

authors： Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

更新日期：1997-11-10 00:00:00

abstract：:We have found that regeneration of the rat sciatic nerve is stimulated if the rats are exposed to a 50 Hz sinusoidal magnetic field. In this study we investigated the effect of a Ca2+ antagonist, methoxyverapamil (D600) on this response. D600 was administered to the regenerating segment of the nerve via implanted osmo...

journal_title：Neuroreport

authors： Rusovan A,Kanje M

更新日期：1992-09-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) attracts considerable attention because it supports survival and differentiation of various types of neurons and glial cells in vitro. Although CNTF functions as a moderate neurotrophic factor in mature motor neurons, its role in embryonic development remains unknown. Here, we found ...

journal_title：Neuroreport

authors： Hata K,Araki M,Yamamori T

更新日期：2002-04-16 00:00:00

abstract：:The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategi...

journal_title：Neuroreport

authors： Frick KM,Stillner ET,Berger-Sweeney J

更新日期：2000-11-09 00:00:00

abstract：:Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the ...

journal_title：Neuroreport

authors： Sheardown MJ

更新日期：1992-10-01 00:00:00

abstract：:To test the hypothesis that the pedunclopontine tegmental nucleus (PPTg) plays a role in anxiety, rats with electrolytic lesions of the PPTg were tested in two animal models of anxiety, the elevated plus maze and the social interaction tests. Histological analysis showed that lesions were concentrated on the caudal ha...

journal_title：Neuroreport

authors： Podhorna J,Franklin KB

更新日期：1998-06-01 00:00:00

abstract：:We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for th...

journal_title：Neuroreport

authors： Jang SH,Cho SH,Kim YH,Kwon YH,Byun WM,Lee SJ,Park SM,Chang CH

更新日期：2004-03-01 00:00:00

abstract：:Acute mitochondrial dysfunction in the cochlea is likely to result in hearing loss as a consequence of local energy shortage, similar to ischemia- or noise-induced hearing loss. To establish an animal model of acute cochlear mitochondrial dysfunction, we applied a mitochondrial toxin, 3-nitropropionic acid (3-NP) in t...

journal_title：Neuroreport

authors： Hoya N,Okamoto Y,Kamiya K,Fujii M,Matsunaga T

更新日期：2004-07-19 00:00:00

abstract：:Two patterns of neuronal firing, bursting and regular spiking, are observed in the somatosensory cortex of anesthetized rats. The effects of excitatory amino acid receptor agonists and antagonists on these discharge types have been examined in vivo, in order to assess their involvement in the generation of such firing...

journal_title：Neuroreport

authors： Kobayashi T,Nagao T,Fukuda H,Hicks TP,Oka JI

更新日期：1993-06-01 00:00:00

abstract：:This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye move...

journal_title：Neuroreport

authors： Leonard TO,Lydic R

更新日期：1995-07-31 00:00:00

abstract：:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microi...

journal_title：Neuroreport

authors： Lee JW,Kim WY,Kim JH

更新日期：2018-04-11 00:00:00

abstract：:Male Bengalese finches sing complex song sequences during courtship. To examine the female perception of sequence complexity, we tested female auditory processing with respect to sequential differences in the caudomedial nidopallium and caudomedial mesopallium. Repeated song presentations caused lower expression of th...

journal_title：Neuroreport

authors： Kato Y,Kato M,Hasegawa T,Okanoya K

更新日期：2010-04-21 00:00:00

abstract：:Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder prevalent in the canine population. It may represent a unique, naturally occurring disease model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs and association with superoxide dismutase 1 gene (SOD1) mutations. M...

journal_title：Neuroreport

authors： Chang RC,Parakh S,Coates JR,Long S,Atkin JD

更新日期：2019-01-02 00:00:00

abstract：:Cultured and transplanted adrenal medullary cells respond to ciliary neurotrophic factor (CNTF) with neurite formation and improved cell survival although the presence of the CNTF receptor-alpha (CNTFRalpha) has been unclear. This study show that CNTFRalpha mRNA was expressed in the postnatal day 1 as well as in the a...

journal_title：Neuroreport

authors： Förander P,Brené S,Strömberg I

更新日期：2000-02-28 00:00:00

abstract：:Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is...

journal_title：Neuroreport

authors： Frak V,Cohen H,Pourcher E

更新日期：2004-06-28 00:00:00

abstract：:Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This...

journal_title：Neuroreport

authors： Van Den Bosch L,Tilkin P,Lemmens G,Robberecht W

更新日期：2002-06-12 00:00:00

abstract：:As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...

journal_title：Neuroreport

authors： Michalski D,Härtig W,Krueger M,Hobohm C,Käs JA,Fuhs T

更新日期：2015-07-08 00:00:00

abstract：:Bilabial, alveolar and velar sounds are produced at different locations around the oral cavity. fMRI was used to localize cortical representation of articulation in seven healthy subjects during repetitive lip and vertical tongue movements as well as repetitive articulation of /pa/ (bilabial), /ta/ (alveolar), /ka/ (v...

journal_title：Neuroreport

authors： Lotze M,Seggewies G,Erb M,Grodd W,Birbaumer N

更新日期：2000-09-11 00:00:00

abstract：:Salidroside (SDS), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has been reported to be neuroprotective in vitro, which raises the possibility of using SDS as a neuroprotective agent after nerve injuries. In the present study, the possibly beneficial effect of SDS on promoting nerve regeneration after ...

journal_title：Neuroreport

authors： Sheng QS,Wang ZJ,Zhang J,Zhang YG

更新日期：2013-03-27 00:00:00

abstract：:Microglial activation plays a critical role in spinal cord ischemic reperfusion injury. Spinal cord stimulation preconditioning and postconditioning has shown spinal cord protection in ischemic reperfusion injury in animal studies. However, whether spinal cord stimulation could reduce microglial activation is still un...

journal_title：Neuroreport

authors： Dong X,Li H,Lu J,Yang Y,Jing H,Cheng Y,Jin M,Cheng W

更新日期：2018-09-26 00:00:00

abstract：:This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cort...

journal_title：Neuroreport

authors： Paradiso S,Crespo Facorro B,Andreasen NC,O'Leary DS,Watkins LG,Boles Ponto L,Hichwa RD

更新日期：1997-09-29 00:00:00

abstract：:The study aimed to investigate the time-course of electromagnetic field (EMF)-induced effects on human cognitive and behavioral performance and on tympanic temperature. Subjects were randomly assigned to two groups, exposed to a 902.40 MHz EMF before the testing session, or to the same signal during the data collectin...

journal_title：Neuroreport

authors： Curcio G,Ferrara M,De Gennaro L,Cristiani R,D'Inzeo G,Bertini M

更新日期：2004-01-19 00:00:00

abstract：:GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing r...

journal_title：Neuroreport

authors： Stanton PK,Potter PE,Aguilar J,Decandia M,Moskal JR

更新日期：2009-08-26 00:00:00

abstract：:Neonatal peripheral inflammation has been shown to alter the neural circuitry of the spinal cord in adult rats. However, the temporal and spatial changes in the distribution of primary afferent terminals immediately following a neonatal inflammatory stimulus remains unclear. In the present study we found that intrapla...

journal_title：Neuroreport

authors： Ling QD,Chien CC,Wen YR,Fu WM,Sun WZ

更新日期：2003-10-27 00:00:00

abstract：:We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...

journal_title：Neuroreport

authors： Tamai Y,Kimura A

更新日期：1996-10-02 00:00:00

abstract：:The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...

journal_title：Neuroreport

authors： O'Rourke KI,Spraker TR,Zhuang D,Greenlee JJ,Gidlewski TE,Hamir AN

更新日期：2007-12-03 00:00:00

abstract：:Correcting for eddy currents, movement-induced distortion and gradient inhomogeneities is imperative when processing diffusion MRI (dMRI) data, but is highly computing resource-intensive. Recently, Compute Unified Device Architecture (CUDA) was implemented for the widely-used eddy-correction software, 'eddy', which re...

journal_title：Neuroreport

authors： Maller JJ,Grieve SM,Vogrin SJ,Welton T

更新日期：2020-07-10 00:00:00