The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels.

abstract：:The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis. We measured...

journal_title：Neuroreport

authors： Gatta LB,Albertini A,Ravid R,Finazzi D

更新日期：2002-11-15 00:00:00

abstract：:We investigated the expression for fibroblast growth factor-2 (FGF-2), in cultured rat cerebellar granule cells and its modulation by Ca2+ regulating agents. There were no significant differences in the levels of FGF-2 mRNA in cells cultured in high vs low K+. The expression of the trophic factor is induced by Ca2+ en...

journal_title：Neuroreport

authors： Roceri M,Molteni R,Racagni G,Riva MA

更新日期：2000-11-09 00:00:00

abstract：:Automatic phrase-building processes were investigated in second-language (L2) learners of French (native German speakers). Event-related brain potentials were recorded while participants listened to syntactically or semantically correct or incorrect French sentences containing a subject-modifying relative clause. Phra...

journal_title：Neuroreport

authors： Isel F

更新日期：2007-12-03 00:00:00

abstract：:The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics: (1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus on...

journal_title：Neuroreport

authors： Ferraresi A,Azzena GB,Troiani D

更新日期：2001-07-03 00:00:00

abstract：:The effect of thyroid hormone (TH) deficiency on the expression of neurofilament (NF) proteins and their intracellular distribution has been examined in primary cultures of neurons from embryonic rat cerebra. Northern blot analysis showed that in TH-deficient (THdef) neurons, the expression of all three NF mRNAs (NF-L...

journal_title：Neuroreport

authors： Rahaman SO,Ghosh S,Mandal SK,Sarkar PK

更新日期：2000-08-21 00:00:00

abstract：:24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease. In this study, we examined the effects of 2...

journal_title：Neuroreport

authors： Alexandrov P,Cui JG,Zhao Y,Lukiw WJ

更新日期：2005-06-21 00:00:00

abstract：:The effect of centrally administered bombesin on core temperature was investigated in rats which had been chronically fitted with a cannula in the third cerebral ventricle and with an intraperitoneal temperature-monitoring radiotransmitter. Intracerebroventricularly administered bombesin (0.01, 0.1 or 1 microgram) res...

journal_title：Neuroreport

authors： Persaud RA,Coen CW

更新日期：1994-03-21 00:00:00

abstract：:Magnetoencephalography (MEG) was used to compare mismatch responses between hemispheres to changes in sound-source direction. Sixteen adults listened passively to two types of complex non-language sounds presented in separate blocks with midline standards and right- and left-lateralized deviants. Mismatch dipole ampli...

journal_title：Neuroreport

authors： Kaiser J,Lutzenberger W,Birbaumer N

更新日期：2000-09-11 00:00:00

abstract：:The aim of the present study was to investigate the effect of intravenous or intrathecal (i.t.) administration of R-phenylisopropyladenosine (R-PIA), a selective A1 adenosine receptor agonist, on spontaneous scratching behaviour, a phenomenon presumably related to pain in a mononeuropathy model (sciatic nerve ligation...

journal_title：Neuroreport

authors： Sjölund KF,Sollevi A,Segerdahl M,Hansson P,Lundeberg T

更新日期：1996-07-29 00:00:00

abstract：:In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...

journal_title：Neuroreport

authors： Ehrlich LC,Hu S,Peterson PK,Chao CC

更新日期：1998-06-01 00:00:00

abstract：:The diversion of attention from a primary goal by irrelevant events is known as attention capture, and is often followed by a directed action. The hypothesis that corticospinal excitability is modulated by attention capture was tested using transcranial magnetic stimulation. Participants watched a video while sounds w...

journal_title：Neuroreport

authors： Mock JR,Foundas AL,Golob EJ

更新日期：2011-11-16 00:00:00

abstract：:Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal mo...

journal_title：Neuroreport

authors： Grant SM,Shankar SL,Chalmers-Redman RM,Tatton WG,Szyf M,Cuello AC

更新日期：1999-01-18 00:00:00

abstract：:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

journal_title：Neuroreport

authors： Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

更新日期：1997-11-10 00:00:00

abstract：:Effects of glutamate on synaptic transmission in the submucosal plexus of guinea-pig small intestine were studied with intracellular electrophysiological recording methods. Glutamate suppressed stimulus-evoked slow excitatory postsynaptic potentials (EPSPs) and increased the amplitude of slow inhibitory postsynaptic p...

journal_title：Neuroreport

authors： Ren J,Hu HZ,Liu S,Xia Y,Wood JD

更新日期：1999-09-29 00:00:00

abstract：:As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...

journal_title：Neuroreport

authors： Ng L,Pedraza PE,Faris JS,Vennström B,Curran T,Morreale de Escobar G,Forrest D

更新日期：2001-08-08 00:00:00

abstract：:GPR39, an orphan G protein-coupled receptor, has been recently identified as the receptor for the bioactive peptide obestatin. Obestatin is secreted from the stomach and acts as an anti-appetite hormone. This activity is induced whether obestatin is administered intraperitoneally or intracerebroventricularly. GPR39 is...

journal_title：Neuroreport

authors： Jackson VR,Nothacker HP,Civelli O

更新日期：2006-05-29 00:00:00

abstract：:It is not clear whether attention is necessary or not for consciousness. We studied the relationship between attention and consciousness by tracking their electrophysiological correlates. The participants attended to visual targets, ignored nontargets in the prespecified visual field and ignored all stimuli in the opp...

journal_title：Neuroreport

authors： Koivisto M,Revonsuo A

更新日期：2007-05-28 00:00:00

abstract：:Subpopulations of olfactory receptor neurons, which are dispersed throughout the olfactory neuroepithelium, express specific cell surface carbohydrates and project to discrete regions of the olfactory bulb. Cell surface carbohydrates such as N-acetyl-lactosamine have been postulated to mediate sorting and selective fa...

journal_title：Neuroreport

authors： Puche AC,Bartlett PF,Key B

更新日期：1997-10-20 00:00:00

abstract：:To observe sequential stages in tactile pattern discrimination and their modification with and without attention, we used whole-head anatomically constrained magnetoencephalography to spatiotemporally map brain responses. Eight, normal, right-handed participants discriminated between two patterns presented on the palm...

journal_title：Neuroreport

authors： Reed CL,Hagler DJ Jr,Marinkovic K,Dale A,Halgren E

更新日期：2009-07-01 00:00:00

abstract：:We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...

journal_title：Neuroreport

authors： Semba J,Sakai M,Miyoshi R,Kito S

更新日期：1995-07-10 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays critical roles in neurotransmission, synaptic plasticity, learning and memory. The aim of this study was to examine, by in situ hybridization, prefrontal cortical expression of CaMKII alpha mRNA in postmortem brains of unipolar, bipolar, schizophrenic, and con...

journal_title：Neuroreport

authors： Xing G,Russell S,Hough C,O'Grady J,Zhang L,Yang S,Zhang LX,Post R

更新日期：2002-03-25 00:00:00

abstract：:In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the righ...

journal_title：Neuroreport

authors： Dinse HR,Ragert P,Pleger B,Schwenkreis P,Tegenthoff M

更新日期：2003-09-15 00:00:00

abstract：:Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRalpha mRNA appeared in a layer...

journal_title：Neuroreport

authors： Ju WK,Kim KY,Lee MY,Hofmann HD,Kirsch M,Cha JH,Oh SJ,Chun MH

更新日期：2000-11-27 00:00:00

abstract：:This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...

journal_title：Neuroreport

authors： Ikeda K,Hayashi A,Matsuda O,Sekiguchi T

更新日期：2010-07-14 00:00:00

abstract：:Regional cerebral blood flow (rCBF) was measured using PET and H2(15)O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left or the right hand. During the execution of the task with ...

journal_title：Neuroreport

authors： Thobois S,Dominey P,Decety J,Pollak P,Gregoire MC,Broussolle E

更新日期：2000-03-20 00:00:00

abstract：:We aimed to ascertain whether pyrethroid insecticides could influence the vesicular transport of the excitatory amino acid glutamate. The incubation of rat cortical synaptic vesicles with resmethrin and permethrin, consistently stimulated both ATP-dependent and -independent uptake of [3H]glutamate, while not evoking d...

journal_title：Neuroreport

authors： Vaccari A,Ruiu S,Mocci I,Saba P

更新日期：1998-10-26 00:00:00

abstract：:Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water flux through the pericapillary (Virchow-Robin) space for both CSF production and reabsorption (Oreskovic and Klarica hypothesis), and challenge the classic CSF circulation theory, which proposes that CSF is primarily produced by ...

journal_title：Neuroreport

authors： Igarashi H,Tsujita M,Kwee IL,Nakada T

更新日期：2014-01-08 00:00:00

abstract：:Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....

journal_title：Neuroreport

authors： Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

更新日期：2007-03-26 00:00:00

abstract：:Optic nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterogra...

journal_title：Neuroreport

authors： Campbell G,Holt JK,Shotton HR,Anderson PN,Bavetta S,Lieberman AR

更新日期：1999-12-16 00:00:00

abstract：:Glial cell-line neurotrophic factor (GDNF), a neurotrophic factor with heparin binding affinity, promotes the survival and differentiation of a variety of neuronal cells including dopaminergic neuron. The effect of heparin on GDNF signaling was investigated based on the expression of the tyrosine hydroxyrase (TH) gene...

journal_title：Neuroreport

authors： Tanaka M,Xiao H,Kiuchi K

更新日期：2002-10-28 00:00:00