Abstract:
:Regional cerebral blood flow (rCBF) was measured using PET and H2(15)O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left or the right hand. During the execution of the task with the left, non-akinetic, hand, cerebral activation in PD patients appeared similar to that of controls. Activated areas were the primary motor cortex, premotor cortex, parietal cortex and cerebellum. When the task was executed with the right, akinetic, hand cerebral activation in PD patients differed from that of controls subjects. The most important change was a bilateral activation of the primary motor cortex. We conclude that overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Thobois S,Dominey P,Decety J,Pollak P,Gregoire MC,Broussolle Edoi
10.1097/00001756-200003200-00026subject
Has Abstractpub_date
2000-03-20 00:00:00pages
785-9issue
4eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 is expressed only in nociceptive sensory neurons. This channel has been proposed to contribute significantly to the sensitization of primary sensory neurons after injury. We have studied the nociceptive behaviours of mice carrying a null mutation in the N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00019
更新日期:2001-10-08 00:00:00
abstract::This study investigated whether neural mechanisms of self-face recognition are modulated by attention by recording event-related brain potentials associated with self-face recognition. Participants identified head orientations of self-faces and familiar or unfamiliar other faces presented briefly at the center of the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203357.65190.61
更新日期:2006-03-20 00:00:00
abstract::Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200206120-00018
更新日期:2002-06-12 00:00:00
abstract::Adult rats were studied for serotonin and its metabolite in basal ganglia, nociceptive responses to electric current and tremor induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) to assess the effects of a single systemic injection of serotonin antiserum given at 1 day old. Antiserum-treated animals showed no over...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::We studied the neural activation associated with the expectancy of emotional stimuli using whole brain fMRI. Fifteen healthy subjects underwent fMRI scanning during which they performed a warned reaction task using emotional pictures carrying pleasant, unpleasant, or neutral content. The task involved an expected or u...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200301200-00010
更新日期:2003-01-20 00:00:00
abstract::The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199202000-00002
更新日期:1992-02-01 00:00:00
abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199710200-00011
更新日期:1997-10-20 00:00:00
abstract::Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199910190-00014
更新日期:1999-10-19 00:00:00
abstract::Methamphetamine (METH) is a drug of abuse used for its stimulant effects. Its neurotoxicity is very variable, and is increased by a number of factors, including crowded conditions and increased ambient temperature. The effects of such factors are increasingly important, with the widespread use of these stimulants at n...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00026
更新日期:2001-10-29 00:00:00
abstract::The mechanisms underlying the prolonged antidepressant effects after a single infusion of ketamine are only partially understood. Ketamine's half-life of ∼2 h cannot explain antidepressant effects that last for 1 week, suggesting the triggering of long-lasting neuroplasticity. Recent human pharmacokinetics (PK) data i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001131
更新日期:2018-11-07 00:00:00
abstract::Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283598de6
更新日期:2012-11-14 00:00:00
abstract::Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835a989e
更新日期:2012-12-19 00:00:00
abstract::Freshly dissected and dissociated subventricular zone cells from adult male mice were transplanted into the right cerebral cortex of adult female mice. Host mice were perfused 3 or 7 weeks later. To detect donor male cells, paraffin sections (10 microm) were hybridized in situ with a Y-chromosome-specific probe. Some ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712220-00018
更新日期:1997-12-22 00:00:00
abstract::Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177015.75096.b6
更新日期:2005-09-08 00:00:00
abstract::Unilateral 6-hydroxydopamine lesion to rat substantia nigra pars compacta resulted in a modest, but significant, decrease in the specific binding of N-alpha-[methyl-3H]histamine (19 +/- 5% reduction) to synaptosomal membranes from ipsilateral striata. Dopamine synthesis was assessed in striatal slices by determining [...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00032
更新日期:2000-01-17 00:00:00
abstract::The present study explored duration mismatch negativity (MMN) reduction in schizophrenia. Duration MMN studies usually employ tones of very short duration (< 200 ms). For stimuli < 200 ms in duration, an increment in duration is accompanied by an increase in perceived loudness. It was previously proposed that the effe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00042
更新日期:2001-12-21 00:00:00
abstract::Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000016
更新日期:2013-11-13 00:00:00
abstract::As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000395
更新日期:2015-07-08 00:00:00
abstract::This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alphavbeta3, and the corresponding cells were isolated and enriched in vitro, then transpla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328303c020
更新日期:2008-07-02 00:00:00
abstract::We investigated the effect of previous musical training on lateralization of language as indexed by the effects of reading aloud on the modulation of motor evoked potentials (MEPs) induced in the first dorsal interosseus muscles (FDI) by transcranial magnetic stimulation (TMS) of the primary motor cortex. We studied 1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00033
更新日期:2002-05-07 00:00:00
abstract::Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00043
更新日期:2001-05-25 00:00:00
abstract::Production and differentiation of olfactory neurons occur in spherical, multi-neuronal aggregates that form in cultures where dissociated newborn rat nasal cells are plated on to CNS glial cells. We show here that neuronal cell bodies were primarily located in the peripheral layers of the spheres, and almost every neu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00003
更新日期:1994-01-31 00:00:00
abstract::We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32836164d4
更新日期:2013-05-29 00:00:00
abstract::Following brain injury astrocytes swell acutely and proliferate thereafter. To investigate the direct relationship between swelling and proliferation, cultured astroglial cells were exposed to 60 mM K+ ion or hypo-osmolar (205 mOsm) electrolyte solution for 1 h to cause transient swelling. Proliferation was assessed b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401000-00027
更新日期:1994-01-31 00:00:00
abstract::The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e328310af58
更新日期:2008-10-08 00:00:00
abstract::In situ hybridization was used to localize mRNA encoding two cooperative serine/threonine kinase receptors. Activin receptor IIA mRNA in the adult rat brain is highly expressed in the dentate gyrus, in the pyramidal neurones of CA3 and CA1, in the entorhinal cortex, in the cortical amygdaloid nucleus and in the amygda...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199011000-00005
更新日期:1990-11-01 00:00:00
abstract::The present study examined the effect of peripherally applied morphine and GABA on jaw muscle electromyographic activity reflexly evoked by co-injection of glutamate into the temporomandibular joint (TMJ) of lightly anesthetized Sprague-Dawley rats of both sexes. In male but not female rats, morphine significantly sup...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200111160-00016
更新日期:2001-11-16 00:00:00
abstract::The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation, nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p5...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00007
更新日期:2001-07-20 00:00:00
abstract::Where and how the cortical areas are activated when a person receives the result of hypothesis testing is still unclear. By using a category induction task, this study provided participants with various batteries and asked them to learn which kind of batteries were charged. After learning, they were required to give a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831d7f6b
更新日期:2009-01-28 00:00:00