Abstract:
:Freshly dissected and dissociated subventricular zone cells from adult male mice were transplanted into the right cerebral cortex of adult female mice. Host mice were perfused 3 or 7 weeks later. To detect donor male cells, paraffin sections (10 microm) were hybridized in situ with a Y-chromosome-specific probe. Some hybridized sections were also immunostained with antibodies against glial fibrillary acidic protein (GFAP), NeuN or beta-tubulin. Grafted cells were identified in 80% of host female brains; they were found in both grey and white matter and were located close to the initial injection site. Double-labelling studies showed that, of the surviving cells containing hybridized male nuclei, 5-10% expressed a glial (GFAP) marker and 6-7% expressed neuronal (NeuN or beta-tubulin) markers.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Harvey AR,Symons NA,Pollett MA,Brooker GJ,Bartlett PFdoi
10.1097/00001756-199712220-00018subject
Has Abstractpub_date
1997-12-22 00:00:00pages
3939-43issue
18eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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