A derivative of a rigid glutamate analog protects the retina from excitotoxicity.

abstract：:Bioelectric activity of CO2-sensitive, ventrolateral medullary neurons (VLN(CS)) in organotypic cultures from the obex level of newborn rats was tested during changes of the intracellular pH (pHi) measured in BCECF-AM loaded cultures. Hypercapnia (pCO2 80-100 mmHg) reduced pHi by 0.15 +/- 0.06 units and stimulated neu...

journal_title：Neuroreport

authors： Wiemann M,Baker RE,Bonnet U,Bingmann D

更新日期：1998-01-05 00:00:00

abstract：:Experience affects how brains respond to sound. Here, we examined how the sensitivity and selectivity of auditory cortical neuronal responses were affected in adult rats by the repeated presentation of a complex sound that was paired with basal forebrain stimulation. The auditory cortical region that was responsive to...

journal_title：Neuroreport

authors： Mercado E,Bao S,Orduña I,Gluck MA,Merzenich MM

更新日期：2001-07-20 00:00:00

abstract：:The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...

journal_title：Neuroreport

authors： Favaron M,Manev RM,Rimland JM,Candeo P,Beccaro M,Manev H

更新日期：1993-09-03 00:00:00

abstract：:It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...

journal_title：Neuroreport

authors： Li A,Lao L,Wang Y,Zhang H,Ren K,Berman BM,Zhang R

更新日期：2007-03-26 00:00:00

abstract：:The aim of this study was to investigate distinct neurometabolites in the right and left thalamus and insula of patients with complex regional pain syndrome (CRPS) compared with healthy controls using proton magnetic resonance spectroscopy. Levels of N-acetylaspartate (NAA), N-acetylaspartylglutamate (NAAG), myo-inosi...

journal_title：Neuroreport

authors： Jung YH,Kim H,Jeon SY,Kwon JM,Kim YC,Lee WJ,Lee D,Lee JY,Moon JY,Kang DH

更新日期：2019-01-16 00:00:00

abstract：:NONINVASIVE photolytic injury to targeted neuronal subpopulations in vivo causes unique, slowly progressive neuronal degeneration. To examine the mechanisms of degeneration toward development and transplantation studies, cytosolic calcium levels were measured in vitro from neocortical neurons after incorporation of ph...

journal_title：Neuroreport

authors： Sheen VL,Dreyer EB,Macklis JD

更新日期：1992-08-01 00:00:00

abstract：:In rapid serial visual presentation of pictures, an early event-related brain potential component shows enlarged negativity over occipital regions for emotional pictures compared with neutral pictures. The present study examined whether the processing of emotional target pictures varies as a function of stimulus repet...

journal_title：Neuroreport

authors： Schupp HT,Stockburger J,Codispoti M,Junghöfer M,Weike AI,Hamm AO

更新日期：2006-03-20 00:00:00

abstract：:We report an investigation into the processing of symmetrical lexical stimuli by a patient with moderate visual neglect. This subject's neglect dyslexia was significantly less pronounced when presented with symmetrical lexical stimuli (palindromes) than with matched non-symmetrical words. We discuss the hypothesis tha...

journal_title：Neuroreport

authors： Shillcock RC,Kelly ML,Monaghan P

更新日期：1998-09-14 00:00:00

abstract：:The precise role of prostaglandin-D-synthase (beta-trace protein), the major constituent of cerebrospinal fluid, is unclear. In the present study, a sensitive and highly specific fluoroimmunoassay was developed. The measurement of the enzyme levels in rat CSF revealed a developmental change in the CSF levels with the ...

journal_title：Neuroreport

authors： Kabeya K,Ishikawa K,Katakai K,Watanabe M,Ohe Y,Wakabayashi K,Mori M

更新日期：1998-03-30 00:00:00

abstract：:In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...

journal_title：Neuroreport

authors： Yamada M,Takahashi K,Ukai W,Hashimoto E,Saito T,Yamada M

更新日期：2010-01-27 00:00:00

abstract：:beta-N-methylamino-L-alanine (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of...

journal_title：Neuroreport

authors： Manzoni OJ,Prezeau L,Bockaert J

更新日期：1991-10-01 00:00:00

abstract：:N-CAM-deficient mice display anatomical and electrophysiological abnormalities in the CNS and behavioral deficits. Here, we address the question whether information processing is altered in these mice by analysis of the expression of c-fos and arg 3.1/arc in N-CAM-deficient mice after presentation of saccharin as nove...

journal_title：Neuroreport

authors： Montag-Sallaz M,Montag D,Schachner M

更新日期：2003-07-18 00:00:00

abstract：:Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...

journal_title：Neuroreport

authors： Verstraeten E,Cluydts R

更新日期：2002-04-16 00:00:00

abstract：:Behavioral and neuropsychological studies suggest that upright and inverted face stimuli are processed by computationally and anatomically distinct systems. Specifically, inverted faces seem to be addressed by general object perception systems, avoiding face-specific processes. We tested this model by examining the fM...

journal_title：Neuroreport

authors： Aguirre GK,Singh R,D'Esposito M

更新日期：1999-01-18 00:00:00

abstract：:Echo-Planar functional magnetic resonance imaging (EP-fMRI) was used to study the activity of the amygdala while three normal female subjects viewed alternating blocks of affectively neutral and affectively negative still pictures. Bilateral activation in the amygdala that was significantly correlated with the changin...

journal_title：Neuroreport

authors： Irwin W,Davidson RJ,Lowe MJ,Mock BJ,Sorenson JA,Turski PA

更新日期：1996-07-29 00:00:00

abstract：:Previous functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal y...

journal_title：Neuroreport

authors： Benedict RH,Lockwood AH,Shucard JL,Shucard DW,Wack D,Murphy BW

更新日期：1998-01-05 00:00:00

abstract：:Plasminogen activators (PAs) have been suggested to play a role in neuronal migration and glial cell proliferation in the developing CNS. Less is known, however, about the role of PAs in the mature nervous system. To elucidate the role of tissue type plasminogen activator (tPA) in the nervous system we used in situ hy...

journal_title：Neuroreport

authors： Yuguchi T,Kohmura E,Yamada K,Otsuki H,Sakaki T,Yamashita T,Nonaka M,Sakaguchi T,Wanaka A,Hayakawa T

更新日期：1997-01-20 00:00:00

abstract：:The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 microM) reversibly reduced the amplitude of voltage-gated A-type potass...

journal_title：Neuroreport

authors： Niu ZD,Yu K,Gu Y,Wang M,She JQ,Chen WH,Ruan DY

更新日期：2005-09-28 00:00:00

abstract：:Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...

journal_title：Neuroreport

authors： Ogata E,Yumoto M,Itoh K,Sekimoto S,Karino S,Kaga K

更新日期：2006-07-31 00:00:00

abstract：:It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...

journal_title：Neuroreport

authors： Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

更新日期：2007-09-17 00:00:00

abstract：:Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...

journal_title：Neuroreport

authors： Meyer JH,Krüger S,Wilson AA,Christensen BK,Goulding VS,Schaffer A,Minifie C,Houle S,Hussey D,Kennedy SH

更新日期：2001-12-21 00:00:00

abstract：:Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced ...

journal_title：Neuroreport

authors： Love S,Barber R,Srinivasan A,Wilcock GK

更新日期：2000-08-03 00:00:00

abstract：:The aim of this study was to identify age-related changes of P300 peak amplitude and P300 latency between closely separated nonsenile age groups (late young-aged adults and early middle-aged adults) and to investigate whether or not P300 has the potential to be used as a measure of cognitive aging even among nonsenile...

journal_title：Neuroreport

authors： Bourisly AK

更新日期：2016-09-28 00:00:00

abstract：:We measured regional cerebral blood flow using positron emission tomography in seven normal volunteers during discrimination tasks for visual patterns. For the 'attention to right or left' tasks, the subjects were instructed to press a key when sample and test stimuli presented in the right or left visual fields, resp...

journal_title：Neuroreport

authors： Kawashima R,Satoh K,Goto R,Inoue K,Itoh M,Fukuda H

更新日期：1998-05-11 00:00:00

abstract：:Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal mo...

journal_title：Neuroreport

authors： Grant SM,Shankar SL,Chalmers-Redman RM,Tatton WG,Szyf M,Cuello AC

更新日期：1999-01-18 00:00:00

abstract：:The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell ...

journal_title：Neuroreport

authors： Fagergren P,Hurd YL

更新日期：1999-11-08 00:00:00

abstract：:Rap1A, first identified as a suppressor of transformed phenotype induced by an activated ras oncogene, is abundantly expressed in the brain. Its neurophysiological function, however, is poorly understood. When an activated Rap1A mutant (Rap1-12V) or a dominant negative H-Ras mutant (Ras-17N) was expressed in CA1 neuro...

journal_title：Neuroreport

authors： Imamura Y,Matsumoto N,Kondo S,Kitayama H,Noda M

更新日期：2003-07-01 00:00:00

abstract：:Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

journal_title：Neuroreport

authors： Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

更新日期：1997-11-10 00:00:00

abstract：:In the present study, we tested the hypothesis that interleukin (IL)-10 down-regulates human microglial cell IL-8 release by inhibiting activation of nuclear factor kappa B (NF-kappaB). Immunohistochemical staining demonstrated that IL-10 markedly suppressed lipopolysaccharide (LPS)- and IL-1beta-stimulated IL-8 expre...

journal_title：Neuroreport

authors： Ehrlich LC,Hu S,Peterson PK,Chao CC

更新日期：1998-06-01 00:00:00

abstract：:Hemispheric differences in the temporal processing of musical sounds within the primary auditory cortex were investigated using functional magnetic resonance imaging (fMRI) time series analysis on a 3.0 T system in right-handed individuals who had no formal training in music. The two hemispheres exhibited a clear-cut ...

journal_title：Neuroreport

authors： Izumi S,Itoh K,Matsuzawa H,Takahashi S,Kwee IL,Nakada T

更新日期：2011-07-13 00:00:00