Abstract:
:The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells on neuronal differentiation, we have co-cultured neuroblastoma x glioma hybrid NG108-15 cells with human bone marrow stromal cells. After co-culturing, clones exhibiting morphological differentiated phenotype and high level of neurofilament expression were isolated. Interestingly, these clones maintain their ability to proliferate in contrast to differentiated NG108-15 cells induced by dibutyryladenosine 3',5'-cyclic monophosphate. These results suggested that bone marrow stromal cells can induce partial differentiation of NG108-15 cells.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ho SH,So LH,Lai KO,Ip NY,Leung MFdoi
10.1097/00001756-199805110-00021subject
Has Abstractpub_date
1998-05-11 00:00:00pages
1365-9issue
7eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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