Abstract:
:Evidence of glutamatergic dysfunction in schizophrenia associated with the N-methyl-D-aspartate receptor has historically demonstrated changes primarily attributable to neurons. We propose an astrocytic component to N-methyl-D-aspartate receptor dysfunction in this illness. We studied the expression of serine racemase, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. We found increased expression in the hippocampus in schizophrenia. This is the first study to demonstrate alterations in schizophrenia of an astrocytic enzyme responsible for synthesizing a neuromodulator, and further evidence that astrocytes may play a direct role in N-methyl-D-aspartate receptor dysfunction in schizophrenia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Steffek AE,Haroutunian V,Meador-Woodruff JHdoi
10.1097/01.wnr.0000230512.01339.72subject
Has Abstractpub_date
2006-07-31 00:00:00pages
1181-5issue
11eissn
0959-4965issn
1473-558Xpii
00001756-200607310-00020journal_volume
17pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The synthesis and release of 3H-acetylcholine was measured in hippocampal slices of adult rat brain following acute in vitro exposure to ethanolamine. Evoked release of 3H-acetylcholine was elevated by 60-70% but 3H-acetylcholine synthesis was unaffected. Other amino alcohols were also found to significantly increase ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199205000-00012
更新日期:1992-05-01 00:00:00
abstract::In a previous event-related fMRI study, we showed that the left occipitotemporal cortex was specifically involved in the abstract categorization of visually presented alphabetic symbols. Here, we duplicate the fMRI study by measuring visual event-related potentials to verify whether the left posterior cortex supports ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200206120-00008
更新日期:2002-06-12 00:00:00
abstract::Insulin-like growth factor (IGF)-I is essential for cerebellar granule neuron survival and a decline in IGF-I is implicated in various age-dependent processes. Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308260-00018
更新日期:2003-08-26 00:00:00
abstract::Amyloid beta-peptide (A beta) is a major component of neuritic plaques, a feature of Alzheimer's disease (AD) brains. Recently, we showed that A beta adopts two major conformational states in solution, which differ in their abilities to form amyloid. These are highly amyloidogenic conformer (A beta ac) with a high con...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199602290-00010
更新日期:1996-02-29 00:00:00
abstract::The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00020
更新日期:1996-12-20 00:00:00
abstract::We investigated the mode of action of argiotoxin636 on isolated N-methyl-D-aspartate (NMDA) receptor channels in cultured cerebellar granule cells. We found that the toxin blocks NMDA channels by decreasing their opening probability and by inducing a flickering activity, in a voltage-dependent manner. Our results indi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00022
更新日期:1995-05-09 00:00:00
abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230503.47973.b7
更新日期:2006-07-31 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00002
更新日期:1997-11-10 00:00:00
abstract::Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199909290-00021
更新日期:1999-09-29 00:00:00
abstract::The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200503150-00003
更新日期:2005-03-15 00:00:00
abstract::High K+- or caffeine-induced Ca2+ signal was studied in freshly dissociated carp retinal ON-type bipolar cells using a confocal laser-scanning microscope. In response to 35 mM K+ exposure, a rise in [Ca2+]i appeared in both the terminal and soma, but was absent after removal of external Ca2+ or in the presence of 100 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199912160-00032
更新日期:1999-12-16 00:00:00
abstract::Birds are capable of dexterous sensory-motor activities such as tool use. Reaching is a crucial component of tool use and is a vision-guided behavior in primates, in which arm movement is monitored online in a stable visual frame. However, vision-guided reaching in primates is enabled by anatomical separation of the h...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000229
更新日期:2014-09-10 00:00:00
abstract::The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103050-00032
更新日期:2001-03-05 00:00:00
abstract::Studies in zebra finches failed to demonstrate the involvement of the NIf, a higher-order song nucleus afferent to the HVc, in the production of learned song. The song of the Bengalese finch, a related species, has a higher level of temporal organization; multiple song phrases are organized into a song. We hypothesize...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00007
更新日期:2000-07-14 00:00:00
abstract::This study is to explore the involvement of muscarinic acetylcholine receptors/protein kinase C cascade and the mitogen-activated protein kinase pathway in the effect of huperzine A on the secretory amyloid precursor protein-alpha. Upregulation of secretory amyloid precursor protein-alpha by huperzine A was attenuated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e28c
更新日期:2007-05-07 00:00:00
abstract::We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199610020-00024
更新日期:1996-10-02 00:00:00
abstract::We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00036
更新日期:2002-01-21 00:00:00
abstract::Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909290-00011
更新日期:1999-09-29 00:00:00
abstract::Adrenocorticotropic hormone (ACTH) is a member of the opiocortin family of peptides. Within the central nervous system, ACTH-synthesizing neurons are generally considered to be located within the hypothalamus and are known to be involved in the neural circuitry underlying the integration of stress responses. We now re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199202000-00001
更新日期:1992-02-01 00:00:00
abstract::Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328330cd2b
更新日期:2009-10-28 00:00:00
abstract::The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for the expression of the contextual freezing behavior. However, it is still unclear whether the amygdala also plays a role in defensive behaviors induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200410050-00028
更新日期:2004-10-05 00:00:00
abstract::Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00059
更新日期:1993-06-01 00:00:00
abstract::Synaptic or 'hard wired' neurotransmission in the brain, subject to modulation by a class of substances called modulators, has been the dominant model of brain function. However, increasing evidence for alternate non-synaptic neurotransmission mechanisms is forcing consideration of a more inclusive model. Evidence is ...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-199304000-00001
更新日期:1993-04-01 00:00:00
abstract::The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle. Intrathecal administr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199410000-00036
更新日期:1994-10-03 00:00:00
abstract::Homotopic and isochronic transplantation of the alar plate of the rhombomeres 7 and 8 was performed between chick and quail embryos at the stage of 10-14 somites. Analysis of the graft derivatives in 12-day-old chimeric embryos by means of the quail nucleolar marker showed that the ipsilateral inferior olive is formed...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00013
更新日期:1996-05-17 00:00:00
abstract::When we look at our spatial environment we have the feeling that the whole visual field is coloured, yet the density of cone photoreceptors decreases considerably as eccentricity increases. We investigated colour perception (coloured/noncoloured), colour naming and whether colour helps object recognition at eccentrici...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236864.54575.98
更新日期:2006-10-23 00:00:00
abstract::Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched con...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834dc301
更新日期:2011-12-21 00:00:00
abstract::The neural origins of the cortical response to rare sensory events remain poorly understood. Using simultaneous event-related potentials and magnetic resonance imaging, we investigated the anatomical profile of regional activity at various processing stages during performance of auditory and visual variants of an oddb...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283435c37
更新日期:2011-02-16 00:00:00
abstract::Acute injury to central nervous system (CNS) triggers neurodegenerative processes that can result in serious damage or complete loss of function. After injury, production of transforming growth factor β1 (TGFβ1) increases and initiates creation of a fibrotic scar that prevents normal growth, plasticity, and recovery o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000106
更新日期:2014-03-26 00:00:00