N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats.

Abstract:

:The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle. Intrathecal administration of both the specific NMDA antagonist (-)-2-amino-7-phosphonoheptanoate and of flupirtine depressed the polysynaptic flexor reflex without affecting the monosynaptic H-reflex. In contrast, the non-NMDA antagonist 6,7-dinitroquinoxaline-2,3-dione depressed the H-reflex without affecting the flexor reflex. The depressant effect of flupirtine on the flexor reflex was prevented by co-administration of NMDA, but not by co-administration of the non-NMDA agonist alpha-amino-3-hydroxy-5-tertbutyl-4-isoxazolepropionic acid. These observations suggest that NMDA might be involved in the action of flupirtine.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Schwarz M,Block F,Pergande G

doi

10.1097/00001756-199410000-00036

subject

Has Abstract

pub_date

1994-10-03 00:00:00

pages

1981-4

issue

15

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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