Abstract:
:Transplanted olfactory ensheathing cells (OECs) have previously been demonstrated to support axonal growth and myelination in the adult rat CNS. Here, the capacity of donor OECs to control the direction of axonal regeneration has been investigated following transplantation, as elongated columns, into the thalamus of adult rats. The OECs formed a 'glial bridge' which extended from the thalamus to the hippocampus. Transplanted OECs rapidly adopted a spindle-shaped morphology which was orientated along the vertical axis of the transplant. Numerous host axons grew into the transplants and followed the highly orientated OEC cell matrix across the choroid fissure. Thus, the spontaneous elongation and orientation of donor OECs may support highly directional host axonal growth across natural barriers within the CNS.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pérez-Bouza A,Wigley CB,Nacimiento W,Noth J,Brook GAdoi
10.1097/00001756-199809140-00010subject
Has Abstractpub_date
1998-09-14 00:00:00pages
2971-5issue
13eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Regional cerebral blood flow (rCBF) was measured using PET and H2(15)O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left or the right hand. During the execution of the task with ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00026
更新日期:2000-03-20 00:00:00
abstract::The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000185013.98821.62
更新日期:2005-11-07 00:00:00
abstract::To assess the effect of endothelial progenitor cells on the axon growth of cortex neurons, we transplanted CD133 cells derived from human peripheral blood to an organotypic coculture system consisting of spinal cord and cortex from neonatal rats. The axon growth from cortex to spinal cord was significantly promoted in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282ff6396
更新日期:2008-05-28 00:00:00
abstract::Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Allelic variations at the MAOA locus have been implicated in the neurobiology of aggression and impulsivity. We investigated the possible...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f94294
更新日期:2008-03-26 00:00:00
abstract::Mental rotation performance has been found to produce one of the largest sex differences in cognition. Many theories suggest that this effect should be accompanied by a sex difference in functional cerebral asymmetry, but empirical data are more than equivocal probably because of (a) the use of inappropriate stimuli a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000198
更新日期:2014-08-06 00:00:00
abstract::The spatial-temporal expression and function of Drosophila melanogaster homothorax (hth) and its vertebrate homologue Meis2 in the eye anlage show a high degree of evolutionary conservation. Both are expressed by progenitor cells ahead of the neurogenic wave front, promote rapid proliferation of these cells, and are d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832000ae
更新日期:2009-02-18 00:00:00
abstract::We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilatera...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906230-00030
更新日期:1999-06-23 00:00:00
abstract::Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum leve...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328331f968
更新日期:2009-11-25 00:00:00
abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199206000-00004
更新日期:1992-06-01 00:00:00
abstract::The organization of the main olfactory bulb of an insectivore, the laboratory shrew (Suncus murinus), was studied morphologically. We found particular small spherical regions, nidi, at the border between the glomerular and external plexiform layer (EPL), which were intensely GAD positive, 30-60 microm in diameter, and...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00012
更新日期:1999-02-05 00:00:00
abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00003
更新日期:1995-01-26 00:00:00
abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00009
更新日期:2003-02-10 00:00:00
abstract::We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00055
更新日期:1996-01-31 00:00:00
abstract::We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00034
更新日期:1995-01-26 00:00:00
abstract::With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199411000-00039
更新日期:1994-11-21 00:00:00
abstract::We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199709080-00012
更新日期:1997-09-08 00:00:00
abstract::Central sensitization is a fundamental mechanism contributing to acute and chronic pain conditions. Our previous studies have documented a glutamatergic, purinergic and glial-dependent central sensitization that can be induced in rat medullary dorsal horn nociceptive neurons by mustard oil application to the tooth pul...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328336eecb
更新日期:2010-02-17 00:00:00
abstract::In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00004
更新日期:1998-03-09 00:00:00
abstract::The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d6b7a
更新日期:2010-09-15 00:00:00
abstract::To determine whether EEG synchronization in sleep has a metabolic equivalent, we investigated state-dependent changes in extracellular concentrations of amino acids. In vivo microdialysis studies were performed in the ventroposterolateral (VPL) nuclei of the thalamus of cats during natural slow wave sleep (SWS), wakin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00025
更新日期:1997-03-24 00:00:00
abstract::Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00047
更新日期:2001-07-03 00:00:00
abstract::Mammals react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed 31P nuclear magnetic resonance spectroscopy of the br...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00009
更新日期:1998-12-01 00:00:00
abstract::Positron emission tomography (PET) was used to investigate cerebral organization in seven subjects who had Mandarin Chinese as their native language (L1), and learned English (L2) later in life. When activation from word repetition was subtracted from verb generation in L1 and L2, CBF increases were observed for both ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199909090-00026
更新日期:1999-09-09 00:00:00
abstract::Physical exercise has many health benefits, including improved cardiovascular fitness, lean muscle development, increased metabolism, and weight loss, as well as positive effects on brain functioning and cognition. Recent evidence suggests that regular physical exercise may also affect the responsiveness of reward reg...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000029
更新日期:2013-12-04 00:00:00
abstract::The distribution of histamine H1, H3, dopamine D1 and D2 receptors in the brain was studied by receptor autoradiography using a high-sensitivity and high-resolution imaging plate system. [3H]Pyrilamine, [3H](R)alpha-methyl-histamine, [11C]SCH23390, and [11C]N-methylspiperone (or [11C]YM-09151-2) were used as ligands t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199211000-00003
更新日期:1992-11-01 00:00:00
abstract::The aim of this study was to show that Cl(-)-dependent excitotoxicity, with its characteristic cell swelling, involves actual water influx into the intracellular compartment. Taking advantage of the Ca2+ omission paradigm of Cl(-)-dependent excitotoxicity, in the chick embryonic neural retina ex vivo, which is associa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011270-00037
更新日期:2000-11-27 00:00:00
abstract::We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00029
更新日期:1997-08-18 00:00:00
abstract::The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00040
更新日期:1997-05-06 00:00:00
abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199710200-00011
更新日期:1997-10-20 00:00:00