Expression of the neuropeptide Y Y1 receptor mRNA in the human brain: an in situ hybridization study.


:Using cRNA in situ hybridization, the regional distribution of mRNA encoding the human Y1 receptor was investigated in the normal human brain and compared with the autoradiographic distribution of putative Y1/[125I][Leu31,Pro34]PYY binding sites. Surprisingly, relatively high levels of Y1 receptor mRNA, distributed in a ty laminar fashion, were detected in the frontal and temporal cortices; laminae I, IV and VI were particularly enriched. The claustrum and nucleus of the medial geniculate body also revealed high levels of Y1 receptor mRNA signals. Moderate levels of specific hybridization were detected in the caudate nucleus, putamen, nucleus accumbens, amygdaloid nuclei, and arcuate and paraventricular nuclei of the hypothalamus. In all these regions, only very low levels of specific [125I][Leu31,Pro34]PYY binding were detected with the exception of the dentate gyrus of the hippocampal formation which expressed rather high levels of both the Y1 receptor mRNA and its translated protein. Accordingly, the human brain can express the Y1 receptor mRNA but this may not necessarily translate into a functional receptor as revealed by low specific binding levels observed in most regions.






Jacques D,Tong Y,Dumont Y,Shen SH,Quirion R




Has Abstract


1996-04-10 00:00:00












  • BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons.

    abstract::In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin NMDA in neuron-enriched cultures and also on apoptotic cell death induced by serum deprivation in mixed neuronal-glial cultures. The neuroprot...


    pub_type: 杂志文章


    authors: Frechilla D,García-Osta A,Palacios S,Cenarruzabeitia E,Del Rio J

    更新日期:2001-04-17 00:00:00

  • Calbindin-D28K, parvalbumin and calretinin in primate lower motor neurons.

    abstract::It has been suggested that lower motor neurons containing calcium-binding proteins (CBP) may be resistant to degeneration in motor neuron disease. The testing of this hypothesis is hampered by lack of comprehensive information regarding the presence of CBPs in motor neurons. To address this shortcoming, we investigate...


    pub_type: 杂志文章


    authors: Fahandejsaadi A,Leung E,Rahaii R,Bu J,Geula C

    更新日期:2004-03-01 00:00:00

  • Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons.

    abstract::Although beta-amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of ...


    pub_type: 杂志文章


    authors: Tabuchi A,Ishii A,Fukuchi M,Kobayashi S,Suzuki T,Tsuda M

    更新日期:2004-06-07 00:00:00

  • 'Theory of mind' in the brain. Evidence from a PET scan study of Asperger syndrome.

    abstract::The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. W...


    pub_type: 临床试验,杂志文章


    authors: Happé F,Ehlers S,Fletcher P,Frith U,Johansson M,Gillberg C,Dolan R,Frackowiak R,Frith C

    更新日期:1996-12-20 00:00:00

  • Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys.

    abstract::Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...


    pub_type: 杂志文章


    authors: Matsuoka N,Aigner TG

    更新日期:1996-01-31 00:00:00

  • Reward acts as a signal to control delay-period activity in delayed-response tasks.

    abstract::Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-deliv...


    pub_type: 杂志文章


    authors: Ichihara-Takeda S,Takeda K,Funahashi S

    更新日期:2010-03-31 00:00:00

  • Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes.

    abstract::The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...


    pub_type: 杂志文章


    authors: Loo DT,Althoen MC,Cotman CW

    更新日期:1994-08-15 00:00:00

  • Phase of electroencephalography theta oscillation during stimulus encoding affects accuracy of memory recall.

    abstract::Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...


    pub_type: 杂志文章


    authors: Jalali A,Tata MS,Gruber AJ,Luczak A

    更新日期:2019-04-10 00:00:00

  • On the origin of Alzheimer's disease: a hypothesis.

    abstract::There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...


    pub_type: 杂志文章


    authors: Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

    更新日期:1993-01-01 00:00:00

  • Presenilin-1 polymorphism and amyloid beta-protein deposition in fatal head injury.

    abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...


    pub_type: 杂志文章


    authors: Zunarelli E,Nicoll JA,Graham DI

    更新日期:1996-12-20 00:00:00

  • Time course of electromagnetic activity associated with detection of rare events.

    abstract::The neural origins of the cortical response to rare sensory events remain poorly understood. Using simultaneous event-related potentials and magnetic resonance imaging, we investigated the anatomical profile of regional activity at various processing stages during performance of auditory and visual variants of an oddb...


    pub_type: 杂志文章


    authors: Rezaie R,Simos PG,Papanicolaou AC,Castillo EM,Moser DC,Passaro AD,Fletcher JM

    更新日期:2011-02-16 00:00:00

  • Desensitizing GABAC receptors on carp retinal bipolar cells.

    abstract::Bicuculline- and baclofen-insensitive GABA receptors (GABAC receptors) on bipolar cells acutely dissociated from carp retina were investigated with using the whole-cell patch-clamp recording technique. The currents of these cells mediated by GABAC receptors showed striking desensitization, even at low concentrations o...


    pub_type: 杂志文章


    authors: Han MH,Li Y,Yang XL

    更新日期:1997-04-14 00:00:00

  • Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage.

    abstract::Cisplatin is a widely used chemotherapeutic drug, but one of its side effects is ototoxicity. Epigenetic-related drugs, such as lysine-specific demethylase 1 (LSD1) inhibitors, have been reported to protect against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2). However, the pro...


    pub_type: 杂志文章


    authors: Li A,He Y,Sun S,Cai C,Li H

    更新日期:2015-06-17 00:00:00

  • Electrophysiological dynamic brain connectivity during symbolic magnitude comparison in children with different mathematics achievement levels.

    abstract::Children with mathematical difficulties usually have an impaired ability to process symbolic representations. Functional MRI methods have suggested that early frontoparietal connectivity can predict mathematic achievements; however, the study of brain connectivity during numerical processing remains unexplored. With t...


    pub_type: 杂志文章


    authors: Gómez-Velázquez FR,Vélez-Pérez H,Espinoza-Valdez A,Romo-Vazquez R,Salido-Ruiz RA,Ruiz-Stovel V,Gallardo-Moreno GB,González-Garrido AA,Berumen G

    更新日期:2017-02-08 00:00:00

  • Pre-exposure to alcohol does not sensitize to the rewarding effects of cocaine.

    abstract::The conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinki...


    pub_type: 杂志文章


    authors: Le Pen G,Duterte-Boucher D,Daoust M,Costentin J

    更新日期:1998-08-24 00:00:00

  • Auditory event-related potentials as a function of abstract change magnitude.

    abstract::Event-related potentials were recorded in healthy volunteers to test the accuracy of the human brain to extract, preattentively, auditory abstract rules. The abstract rule was determined by the frequency relationship between two pure tones forming a pair. The standard pairs had identical tone frequency, whereas the de...


    pub_type: 杂志文章


    authors: Carral V,Corral MJ,Escera C

    更新日期:2005-02-28 00:00:00

  • Neurogenesis in adult human.

    abstract::This report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not g...


    pub_type: 杂志文章


    authors: Murrell W,Bushell GR,Livesey J,McGrath J,MacDonald KP,Bates PR,Mackay-Sim A

    更新日期:1996-04-26 00:00:00

  • Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus.

    abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...


    pub_type: 杂志文章


    authors: Janik D,Mrosovsky N

    更新日期:1992-07-01 00:00:00

  • Effect of hindlimb unloading on stereological parameters of the motor cortex and hippocampus in male rats.

    abstract::Hindlimb unloading (HU) can cause motion and cognition dysfunction, although its cellular and molecular mechanisms are not well understood. The aim of the present study was to determine the stereological parameters of the brain areas involved in motion (motor cortex) and spatial learning - memory (hippocampus) under a...


    pub_type: 杂志文章


    authors: Salehi MS,Mirzaii-Dizgah I,Vasaghi-Gharamaleki B,Zamiri MJ

    更新日期:2016-11-09 00:00:00

  • Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4.

    abstract::MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...


    pub_type: 杂志文章


    authors: Xiao J,Kong R,Hu J

    更新日期:2018-06-13 00:00:00

  • Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha.

    abstract::The protein p42(IP4) (also called centaurin alpha), identified as a brain-specific InsP4/PtdInsP3 (PIP3)-binding protein, has been shown to be localized in human brain, specifically expressed in neurons. Several casein kinases have been found to be involved in Alzheimer's disease (AD) pathology. Since casein kinase I ...


    pub_type: 杂志文章


    authors: Reiser G,Bernstein HG

    更新日期:2002-12-20 00:00:00

  • Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brain.

    abstract::NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...


    pub_type: 杂志文章


    authors: Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

    更新日期:2000-08-03 00:00:00

  • Endogenous NGF and CNTF levels in human peripheral nerve injury.

    abstract::Nerve growth factor (NGF) is trophic to sensory and sympathetic fibres, and ciliary neurotrophic factor (CNTF) to motoneurones, in animal models of peripheral nerve injury: NGF excess produces hyperalgesia. In this first study of injured human nerves and sensory ganglia, we quantified and localized endogenous NGF and ...


    pub_type: 临床试验,杂志文章


    authors: Anand P,Terenghi G,Birch R,Wellmer A,Cedarbaum JM,Lindsay RM,Williams-Chestnut RE,Sinicropi DV

    更新日期:1997-05-27 00:00:00

  • fMRI of human somatosensory and cingulate cortex during painful electrical nerve stimulation.

    abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...


    pub_type: 杂志文章


    authors: Davis KD,Wood ML,Crawley AP,Mikulis DJ

    更新日期:1995-12-29 00:00:00

  • Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity.

    abstract::Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....


    pub_type: 杂志文章


    authors: Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

    更新日期:2007-03-26 00:00:00

  • Cocaine alters body temperature and behavioral thermoregulatory responses.

    abstract::This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degr...


    pub_type: 杂志文章


    authors: Gonzalez LP

    更新日期:1993-01-01 00:00:00

  • Fenfluramine-induced c-fos in the striatum and hypothalamus: a tract-tracing study.

    abstract::Systemic administration of DL-fenfluramine (20 mg kg-1), an indirect serotonergic agonist, induced widespread FOS-like protein in the rat caudate putamen (CPu), paraventricular nucleus (PVn) of the hypothalamus and several intralaminar thalamic nuclei. To ascertain whether the dopaminergic nigrostriatal system coordin...


    pub_type: 杂志文章


    authors: Torres G

    更新日期:1995-08-21 00:00:00

  • Activity in the human primary motor cortex related to arm and finger movements.

    abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...


    pub_type: 杂志文章


    authors: Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Yanagisawa T

    更新日期:1995-01-26 00:00:00

  • Methionine synthase polymorphism is a risk factor for Alzheimer disease.

    abstract::Alzheimer disease (AD) patients show increased plasma levels of homocysteine, whose conversion to methionine is catalyzed by methionine synthase (MS). Although altered MS activity may result from the MS A2756G polymorphism, the latter's possible associ-ation with AD remains unexplored. To assess whether the MS A2756G ...


    pub_type: 杂志文章


    authors: Beyer K,Lao JI,Latorre P,Riutort N,Matute B,Fernández-Figueras MT,Mate JL,Ariza A

    更新日期:2003-07-18 00:00:00

  • Effects of diazepam and D-amphetamine on rhythmic pattern of eye movements in goldfish.

    abstract::The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...


    pub_type: 杂志文章


    authors: Salas C,Navarro F,Torres B,Delgado-Garcia JM

    更新日期:1992-02-01 00:00:00