Localization of mGluR4 protein in the rat cerebral cortex and hippocampus.

abstract：:We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line....

journal_title：Neuroreport

authors： Raab-Graham KF,Radeke CM,Vandenberg CA

更新日期：1994-12-20 00:00:00

abstract：:In line with a possible role of vergence in orienting visual attention, we sought to study this eye movement in young children to provide insights on face perception. For this purpose, we measured the modulation in the angle of eye vergence in a sample of 39 children aged 6-36 months and compared it when presenting st...

journal_title：Neuroreport

authors： Esposito FL,Supèr H

更新日期：2018-02-07 00:00:00

abstract：:To study the number cognition process, we recorded event-related potentials (ERPs) in 14 subjects when they were indicating whether a number pair was the same or not. The two numbers given in sequence were either the same (condition 1) or different (condition 2). After 270 ms following the onset of the second stimulus...

journal_title：Neuroreport

authors： Kong J,Wang Y,Zhang W,Wang H,Wei H,Shang H,Yang X,Zhuang D

更新日期：2000-04-27 00:00:00

abstract：:During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this i...

journal_title：Neuroreport

authors： Geng X,Xiao L,Tao Q,Hu R,Rupp RA,Ding X

更新日期：2003-12-02 00:00:00

abstract：:Adenovirus vectors containing a marker gene (lacZ from Escherichia coli) are potent for transferring the gene to neurones after intraparenchymal injections. Expression of the marker gene may lead to the synthesis of an enormous amount of beta-galactosidase which diffuses throughout the entire neurone, providing a 'Gol...

journal_title：Neuroreport

authors： Lisovoski F,Cadusseau J,Akli S,Caillaud C,Vigne E,Poenaru L,Stratford-Perricaudet L,Pericaudet M,Kahn A,Peschanski M

更新日期：1994-05-09 00:00:00

abstract：:We compared various measures of visual-vestibular interaction in subjects with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM), as well as non-diabetic controls. Subjects with IDDM exhibited significantly greater postural sway than controls on those conditions in the Clini...

journal_title：Neuroreport

authors： Darlington CL,Erasmus J,Nicholson M,King J,Smith PF

更新日期：2000-02-28 00:00:00

abstract：:We investigated the mode of action of argiotoxin636 on isolated N-methyl-D-aspartate (NMDA) receptor channels in cultured cerebellar granule cells. We found that the toxin blocks NMDA channels by decreasing their opening probability and by inducing a flickering activity, in a voltage-dependent manner. Our results indi...

journal_title：Neuroreport

authors： Fagni L,Bockaert J

更新日期：1995-05-09 00:00:00

abstract：:We investigated the effect of an NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), on the levels of endogenous GABA in the rat striatum using in vivo microdialysis. Rats were perfused with the artificial CSF containing L-NMMA (0.1, 0.3 and 1.0 mM) or its inactive isomer D-NMMA (1.0 mM) for 1 h. Infusion of L-N...

journal_title：Neuroreport

authors： Semba J,Sakai M,Miyoshi R,Kito S

更新日期：1995-07-10 00:00:00

abstract：:The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for the expression of the contextual freezing behavior. However, it is still unclear whether the amygdala also plays a role in defensive behaviors induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present st...

journal_title：Neuroreport

authors： Oliveira LC,Nobre MJ,Brandão ML,Landeira-Fernandez J

更新日期：2004-10-05 00:00:00

abstract：:We investigated the reactive cytoskeletal changes following physical damage to axons in the rodent neocortex and compared these with the earliest neuronal alterations seen in Alzheimer's disease (AD). Insertion of a 25 gauge needle into the rodent somatosensory cortex resulted in ring- and club-like axonal changes cha...

journal_title：Neuroreport

authors： King CE,Jacobs I,Dickson TC,Vickers JC

更新日期：1997-05-06 00:00:00

abstract：:The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

journal_title：Neuroreport

authors： Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

更新日期：2001-01-22 00:00:00

abstract：:Regulation of CNTF mRNA was investigated in primary cortical astrocytes cultured from newborn rats and in C6 glioma cells. Northern blot analysis indicated that semi-confluent astrocyte cell cultures. CNTF added to confluent astrocyte cultures down-regulated CNTF message in a dose-dependent fashion. In contrast, when ...

journal_title：Neuroreport

authors： Meyer V,Unsicker K

更新日期：1994-10-03 00:00:00

abstract：:The auditory-evoked potential's N1 component of the scalp electroencephalogram is a well-established measure of electrical brain activity. The N1 reflects basic auditory processing and is modulated by auditory experience, for instance, by musical training. Here, we explore a possible correlation between the auditory N...

journal_title：Neuroreport

authors： Liem F,Zaehle T,Burkhard A,Jäncke L,Meyer M

更新日期：2012-12-05 00:00:00

abstract：:Amyloid plaques and neurofibrillary tangles are the major pathological hallmarks of Alzheimer's disease. Neurofibrillary tangles are composed of filaments and paired helical filaments containing polymerized hyperphosphorylated tau protein. Derlin proteins are a family of proteins that are conserved in all eukaryotes, ...

journal_title：Neuroreport

authors： Honjo Y,Ito H,Horibe T,Shimada H,Nakanishi A,Mori H,Takahashi R,Kawakami K

更新日期：2012-07-11 00:00:00

abstract：:Disturbances in methyl-carbon metabolism, which result in hyperhomocysteinemia, have been associated with schizophrenia. Homozygosity for the T677 allele of the methylenetetrahydrofolate reductase (MTHFR) gene, which encodes for a thermolabile enzyme associated with hyperhomocysteinemia, has been found to be increased...

journal_title：Neuroreport

authors： Virgos C,Martorell L,Simó JM,Valero J,Figuera L,Joven J,Labad A,Vilella E

更新日期：1999-07-13 00:00:00

abstract：:The human kallikrein gene family consists of 15 serine proteases. We examined the expression of the kallikrein genes in human cerebral cortex and hippocampus by RT-PCR and compared their expression between Alzheimer's disease (AD) and control tissue. KLK1, 4, 5, 6, 7, 8, 10, 11, 13 and 14 are expressed in both cerebra...

journal_title：Neuroreport

authors： Shimizu-Okabe C,Yousef GM,Diamandis EP,Yoshida S,Shiosaka S,Fahnestock M

更新日期：2001-08-28 00:00:00

abstract：:In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-res...

journal_title：Neuroreport

authors： Yaguchi T,Nagata T,Mukasa T,Fujikawa H,Yamamoto H,Yamamoto S,Iso H,Tanaka A,Nishizaki T

更新日期：2006-01-23 00:00:00

abstract：:BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In sali...

journal_title：Neuroreport

authors： Belcadi-Abbassi W,Destrade C

更新日期：1995-06-19 00:00:00

abstract：OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...

journal_title：Neuroreport

authors： Yano H,Soeta Y

更新日期：2021-01-13 00:00:00

abstract：:Perception of apparent motion operates somewhat differently for objects and human figures. Depending on the interstimulus interval, the latter d may give rise to either perception of a direct path (i.e. biologically impossible) or indirect path (i.e. biologically possible). Here, PET was used to investigate whether a ...

journal_title：Neuroreport

authors： Stevens JA,Fonlupt P,Shiffrar M,Decety J

更新日期：2000-01-17 00:00:00

abstract：:Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...

journal_title：Neuroreport

authors： Banz BC,Wu J,Camenga DR,Mayes LC,Crowley MJ,Vaca FE

更新日期：2020-05-22 00:00:00

abstract：:The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...

journal_title：Neuroreport

authors： Tellam DJ,Perone MJ,Dunn IC,Radovick S,Brennand J,Rivier JE,Castro MG,Lovejoy DA

更新日期：1998-10-05 00:00:00

abstract：:With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...

journal_title：Neuroreport

authors： Gulyás B,Roland PE,Heywood CA,Popplewell DA,Cowey A

更新日期：1994-11-21 00:00:00

abstract：:Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase posit...

journal_title：Neuroreport

authors： Schierle GS,Karlsson J,Brundin P

更新日期：1998-05-11 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained unclear. In this study, we investigated the roles of SIRT2 in...

journal_title：Neuroreport

authors： Nie H,Hong Y,Lu X,Zhang J,Chen H,Li Y,Ma Y,Ying W

更新日期：2014-08-06 00:00:00

abstract：:The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a...

journal_title：Neuroreport

authors： Pavlides C,Kimura A,Magariños AM,McEwen BS

更新日期：1994-12-20 00:00:00

abstract：:Experience affects how brains respond to sound. Here, we examined how the sensitivity and selectivity of auditory cortical neuronal responses were affected in adult rats by the repeated presentation of a complex sound that was paired with basal forebrain stimulation. The auditory cortical region that was responsive to...

journal_title：Neuroreport

authors： Mercado E,Bao S,Orduña I,Gluck MA,Merzenich MM

更新日期：2001-07-20 00:00:00

abstract：:Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...

journal_title：Neuroreport

authors： Chen X,Wei D,Dupuis-Roy N,Du X,Qiu J,Zhang Q

更新日期：2012-12-19 00:00:00

abstract：:This report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not g...

journal_title：Neuroreport

authors： Murrell W,Bushell GR,Livesey J,McGrath J,MacDonald KP,Bates PR,Mackay-Sim A

更新日期：1996-04-26 00:00:00

abstract：:Mutations in the presenilin genes are involved in the aetiology of the majority of familial early-onset Alzheimer disease (AD) cases. Presenilin 1 (PS1) is proteolytically processed in vivo, resulting in the accumulation of N-terminal approximately 27-28 kDa and C-terminal approximately 18 kDa derivatives. To examine ...

journal_title：Neuroreport

authors： Hendriks L,Thinakaran G,Harris CL,De Jonghe C,Martin JJ,Sisodia SS,Van Broeckhoven C

更新日期：1997-05-06 00:00:00