Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

Abstract:

:Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Weydt P,Möller T

doi

10.1097/00001756-200504250-00001

subject

Has Abstract

pub_date

2005-04-25 00:00:00

pages

527-31

issue

6

eissn

0959-4965

issn

1473-558X

pii

00001756-200504250-00001

journal_volume

16

pub_type

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