Abstract:
:Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Weydt P,Möller Tdoi
10.1097/00001756-200504250-00001subject
Has Abstractpub_date
2005-04-25 00:00:00pages
527-31issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200504250-00001journal_volume
16pub_type
杂志文章,评审相关文献
NEUROREPORT文献大全abstract::Upon perfusion with Mg2+-free artificial cerebrospinal fluid (ACSF) organotypic hippocampal slice cultures develop seizure-like events and tonic recurrent discharges in which areas CA3 and CA1 and, in contrast to acute slices, also the dentate gyrus (DG) participate. Using the fluorescent dye propidium iodide (PI) we ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00002
更新日期:1999-02-05 00:00:00
abstract::In a previous publication we showed that non-linear analysis can extract spatio-temporal changes of brain electrical activity prior to epileptic seizures. Here we describe a new method to analyze this long-term non-stationarity in the EEG by a measure of dynamical similarity between different parts of the time series....
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199907130-00028
更新日期:1999-07-13 00:00:00
abstract::We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00035
更新日期:1994-12-20 00:00:00
abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199201000-00028
更新日期:1992-01-01 00:00:00
abstract::Subthalamic nucleus (STN) hyperactivity follows lesions of mesencephalic dopaminergic neurons in animal models of Parkinson's disease. The mechanism leading to sustained STN hyperactivity in parkinsonism is not well understood, but it seems not to depend on the integrity of striato-pallido-subthalamic connections (the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199905140-00020
更新日期:1999-05-14 00:00:00
abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00002
更新日期:2000-01-17 00:00:00
abstract::Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000373
更新日期:2015-06-17 00:00:00
abstract::Changes in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703030-00036
更新日期:1997-03-03 00:00:00
abstract::In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199911080-00014
更新日期:1999-11-08 00:00:00
abstract::We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a smal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199401120-00028
更新日期:1994-01-12 00:00:00
abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199207000-00007
更新日期:1992-07-01 00:00:00
abstract::Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::In order to clarify whether neurophysiological profiles affect the performance of brain machine interfaces (BMI), we examined the relationships between amplitudes of movement-related cortical fields (MRCFs) and decoding performances during movement. Neuromagnetic activities were recorded in nine healthy participants d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834d935a
更新日期:2012-01-04 00:00:00
abstract::Transcranial magnetic stimulation (TMS) was applied over the frontal eye field (FEF) and the supplementary eye field (SEF) regions before execution of the first saccade in a double step task. When applied over the FEF, stimulation increased the percentage error in amplitude of the contralateral second saccade as compa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200202110-00016
更新日期:2002-02-11 00:00:00
abstract::We examined covert and overt orienting in response to non-predictive gaze direction cues and investigated whether the subcortical superior colliculus (SC) plays a role in this type of orienting. Participants viewed a centrally presented gazing schematic face and responded to targets appearing at gazed-at or non-gazed-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200303030-00039
更新日期:2003-03-03 00:00:00
abstract::Previous studies have demonstrated induced gamma-band activity (GBA) over posterior temporo-parietal and inferior frontal cortex during auditory spatial vs pattern mismatch processing, respectively. Here we investigated magnetoencephalographic oscillatory responses during an active auditory pattern oddball task. Fourt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200410050-00008
更新日期:2004-10-05 00:00:00
abstract::Activation of mu-opioid receptors is critical to steroid regulation of female sexual behavior, lordosis, in rodents. Estrogen treatment activates mu-opioid receptors in the medial preoptic area inhibiting lordosis, but ultimately appears important for progesterone facilitation of lordosis. We investigated the role of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000181585.49130.93
更新日期:2005-10-17 00:00:00
abstract::The cellular distribution of the rat metabotropic glutamate receptor type 4 (mGluR4) was examined in the adult rat cerebral cortex and hippocampus. Antibodies were raised against amino acid residues located in the extracellular amino terminal domain that is common to both the mGluR4a and mGluR4b splice variants, and u...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199710200-00031
更新日期:1997-10-20 00:00:00
abstract::The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for the expression of the contextual freezing behavior. However, it is still unclear whether the amygdala also plays a role in defensive behaviors induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present st...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200410050-00028
更新日期:2004-10-05 00:00:00
abstract::With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00003
更新日期:1995-01-26 00:00:00
abstract::Reactive gliosis is a prominent morphological feature of temporal lobe epilepsy. The molecular mechanisms underlying glial cell activation remain unclear. We examined expression of Id1-3 protein, a family of helix--loop--helix proteins involved in the regulation of cell proliferation and differentiation, in glial cell...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00035
更新日期:2001-08-08 00:00:00
abstract::Results from a computer model of a thalamic network predict that agents augmenting GABA(A)-mediated inhibition in the reticular thalamic (RE) nucleus will be antiepileptic or desynchronizing. This provides support for the hypothesis that antiepileptics like benzodiazepines may exert their effects through an isolated i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00024
更新日期:1998-03-09 00:00:00
abstract::NMR signal intensities in five regions of the midsagittal corpus callosum were measured in autism patients and normal controls. An age-related increase in signal was observed in the anterior regions in both groups. No significant differences in intensity were detected between the groups. The finding of normal myelinat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199506090-00006
更新日期:1995-06-19 00:00:00
abstract::Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00045
更新日期:1999-04-06 00:00:00
abstract::Hydrogen peroxide (H₂O₂) is a ubiquitous reactive oxygen species that can induce several inner ear disorders. In this study, we recorded the potassium (K) currents in acutely isolated inner hair cells of guinea pig cochlea, and investigated the effects of H₂O₂. We also observed the morphological changes in inner hair ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833fcb56
更新日期:2010-11-17 00:00:00
abstract::Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00059
更新日期:1993-06-01 00:00:00
abstract::Functional neuroimaging studies of handedness have traditionally focused on exploring regionally activated discrepancies, yet little is known regarding the effect of handedness on functional connections of brain regions. Here, we reported the relationship between cerebellar functional connectivity patterns and handedn...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000192737.92911.a4
更新日期:2006-01-23 00:00:00
abstract::Extracellular recordings were used to determine the effects of cannabinoids on the activity of dopamine neurons within the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC). Systemic administration of the natural psychoactive cannabinoid delta 9-tetrahydrocannabinol (delta 9-THC) and the synthetic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00014
更新日期:1997-02-10 00:00:00
abstract::We have previously reported that antidepressants such as desipramine (DMI) induce axonal regeneration of brain noradrenergic neurons. In the present experiments, the role of phospholipase A2 (PLA2) in the regeneration of brain noradrenergic axons was studied. Symmetrical sites of the rat frontal cortex were pretreated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199304000-00007
更新日期:1993-04-01 00:00:00
abstract::We have evaluated the G1H line of transgenic mice overexpressing a familial ALS mutation of SOD1 (Gly-93-->Ala) in tasks assessing different aspects of motor function to determine how early these deficits could be detected and their order of appearance. The earliest deficits were observed in tests of muscle strength a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199709080-00012
更新日期:1997-09-08 00:00:00