Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.


:Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and its animal models. A better understanding of neuroinflammation in motor neuron degeneration and amyotrophic lateral sclerosis disease progression promises to improve the rational design of greatly needed therapies.






Weydt P,Möller T




Has Abstract


2005-04-25 00:00:00














  • Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs.

    abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...


    pub_type: 杂志文章


    authors: Ghauri M,Chapman AG,Meldrum BS

    更新日期:1996-06-17 00:00:00

  • Post-test apamin injection suppresses a Kamin-like effect following a learning session in mice.

    abstract::BALB/c mice were trained in a partial acquisition session of an appetitive bar-pressing task. They then received an immediate post-acquisition i.p. injection of either saline or apamin 0.2 mg kg-1. Each group was submitted to a retention test that was delayed either 25, 85 or 180 min after initial acquisition. In sali...


    pub_type: 杂志文章


    authors: Belcadi-Abbassi W,Destrade C

    更新日期:1995-06-19 00:00:00

  • The serotonin transporter is a potential susceptibility factor for bipolar affective disorder.

    abstract::The serotonin transporter is a strong candidate for aetiological involvement in affective disorders and psychosis. We analysed a VNTR in intron 2 of the human serotonin transporter gene (hSERT) for allelic association with bipolar affective disorder, unipolar depression and schizophrenia. An increased frequency of all...


    pub_type: 杂志文章


    authors: Collier DA,Arranz MJ,Sham P,Battersby S,Vallada H,Gill P,Aitchison KJ,Sodhi M,Li T,Roberts GW,Smith B,Morton J,Murray RM,Smith D,Kirov G

    更新日期:1996-07-08 00:00:00

  • Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain.

    abstract::Calsenilin, a multifunctional Ca2+-binding protein, has been identified as an Alzheimer's disease-associated presenilin interactor. Here, we investigated the histochemical localization of calsenilin and its expression levels in the brains of sporadic Alzheimer's disease. Both messenger RNA and protein expression of ca...


    pub_type: 杂志文章


    authors: Jin JK,Choi JK,Wasco W,Buxbaum JD,Kozlowski PB,Carp RI,Kim YS,Choi EK

    更新日期:2005-04-04 00:00:00

  • Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.

    abstract::Dopamine D2 receptor (D2R) signalling is implicated in limbic seizure propagation and seizure-induced neurodegeneration. D2R-/- mice display increased susceptibility to kainic acid (KA) seizures and seizure-induced apoptosis of hippocampal neurons. Here we further investigated the molecular pathways of KA-induced apop...


    pub_type: 杂志文章


    authors: Tripathi PP,Santorufo G,Brilli E,Borrelli E,Bozzi Y

    更新日期:2010-08-23 00:00:00

  • Semantic sentence processing reflected in the event-related potentials of one- and two-year-old children.

    abstract::The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...


    pub_type: 杂志文章


    authors: Friedrich M,Friederici AD

    更新日期:2005-11-07 00:00:00

  • Auditory temporal resolution in children assessed by magnetoencephalography.

    abstract::By means of magnetoencephalography we investigated the auditory-evoked fields (AEFs) elicited by broadband noise bursts in a gap-detection paradigm in children. AEFs of 16 healthy children (mean age 8.7 years) were recorded while they passively listened to 100-ms white-noise bursts with temporal gaps of 3, 6, 10 and 3...


    pub_type: 杂志文章


    authors: Diedler J,Pietz J,Bast T,Rupp A

    更新日期:2007-10-29 00:00:00

  • Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory.

    abstract::The time-dependent effect of transcranial direct current stimulation (tDCS) on working memory was investigated by applying anodal stimulation over the left prefrontal cortex. This single-blind, sham-controlled crossover study recruited 15 healthy participants. A three-back verbal working-memory task was performed befo...


    pub_type: 临床试验,杂志文章


    authors: Ohn SH,Park CI,Yoo WK,Ko MH,Choi KP,Kim GM,Lee YT,Kim YH

    更新日期:2008-01-08 00:00:00

  • Age-dependent changes in distribution of P3a/P3b amplitude and thickness of the cerebral cortex.

    abstract::With increasing age, the electrophysiological event-related potentials P3a/P3b tend to get a more frontal maximum. The cognitive significance of this so-called frontal shift is not known, but hypotheses have focused on changes in the integrity of the frontal lobes. The aim of the present study was to test how the thic...


    pub_type: 杂志文章


    authors: Fjell AM,Walhovd KB,Reinvang I

    更新日期:2005-09-08 00:00:00

  • A magnetoencephalography spatiotemporal analysis of neural activities during feature binding.

    abstract::Previous literature shows that feature binding processes elicit fronto-hippocampal areas. The time course of this process, however, remains unknown. This is the first study that investigates feature binding using magnetoencephalography. Synthetic aperture magnetometry analysis was used to localize sources of increased...


    pub_type: 杂志文章


    authors: Filbey FM,Holroyd T,Carver F,Sunderland T,Cohen RM

    更新日期:2005-11-07 00:00:00

  • Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice.

    abstract::Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...


    pub_type: 杂志文章


    authors: Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

    更新日期:1997-11-10 00:00:00

  • Electrophysiological correlates of reduced pain perception after theta-burst stimulation.

    abstract::In an earlier study, we reported the antinociceptive effects of a special repetitive transcranial magnetic stimulation paradigm: continuous theta-burst stimulation (cTBS), when applied to human motor cortex. Here, we investigated whether the reduced subjective pain perception of 10 healthy individuals could be measure...


    pub_type: 杂志文章


    authors: Csifcsak G,Nitsche MA,Baumgärtner U,Paulus W,Treede RD,Antal A

    更新日期:2009-08-05 00:00:00

  • POU-domain factor expression in the trigeminal ganglion and implications for herpes virus regulation.

    abstract::The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. Based primarily on work in sensory-related cell lines, several prior reports have suggested that the POU-domain transcription factor Oct-...


    pub_type: 杂志文章


    authors: Turner EE,Fedtsova N,Rosenfeld MG

    更新日期:1996-11-25 00:00:00

  • Biochemical markers of cognition: a proton MR spectroscopy study of normal human brain.

    abstract::In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...


    pub_type: 临床试验,杂志文章


    authors: Jung RE,Yeo RA,Chiulli SJ,Sibbitt WL Jr,Weers DC,Hart BL,Brooks WM

    更新日期:1999-11-08 00:00:00

  • Expression of human glutamate receptors (GluR) in neuroblastoma cell lines.

    abstract::Neuroblastoma cell lines are useful for the investigation of neuronal receptor regulation since these cells display various neuronal features. Here we report the analysis of human AMPA and kainate receptor expression in four neuroblastoma cell lines (SK-N-MC, IMR-32, CHP 126 and NMB/N7). The reverse transcriptase-poly...


    pub_type: 杂志文章


    authors: Korczak B,McWhinnie EA,Fletcher EJ,Kamboj RK

    更新日期:1995-04-19 00:00:00

  • CEP-1347 promotes survival of NGF responsive neurones in primary DRG explants.

    abstract::CEP-1347 inhibits the signalling pathway of c-jun-N-terminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth; NGF withdrawal results in apoptotic cell death. We examined the neuroprotective and neurite outgrowth ...


    pub_type: 杂志文章


    authors: Bilsland JG,Harper SJ

    更新日期:2003-05-23 00:00:00

  • Regional and sex-dependent alterations in Purkinje cell density in the valproate mouse model of autism.

    abstract::Neuropathological and neuroimaging studies indicate a decrease in Purkinje cell (PC) density in the cerebellum of autistic patients and rodent models of autism. Autism is far more prevalent in males than females, and sex-specific properties of PCs have been reported recently. We investigated the differential sensitivi...


    pub_type: 杂志文章


    authors: Roux S,Bailly Y,Bossu JL

    更新日期:2019-01-16 00:00:00

  • pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices.

    abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...


    pub_type: 杂志文章


    authors: Kaila K,Paalasmaa P,Taira T,Voipio J

    更新日期:1992-01-01 00:00:00

  • Human area 5 modulates corticospinal output during movement preparation.

    abstract::Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence o...


    pub_type: 杂志文章


    authors: Mackenzie TN,Bailey AZ,Mi PY,Tsang P,Jones CB,Nelson AJ

    更新日期:2016-09-28 00:00:00

  • Simultaneous bilateral mismatch response to right- but not leftward sound lateralization.

    abstract::Magnetoencephalography (MEG) was used to compare mismatch responses between hemispheres to changes in sound-source direction. Sixteen adults listened passively to two types of complex non-language sounds presented in separate blocks with midline standards and right- and left-lateralized deviants. Mismatch dipole ampli...


    pub_type: 杂志文章


    authors: Kaiser J,Lutzenberger W,Birbaumer N

    更新日期:2000-09-11 00:00:00

  • Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.

    abstract::When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the fo...


    pub_type: 更正并重新发布的文章,杂志文章


    authors: O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F,Kobal G,Renner B,Ahne G

    更新日期:2000-03-20 00:00:00

  • Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS.

    abstract::Myristoylated alanine-rich C kinase substrate (MARCKS), an acidic protein associated with cell motility and phagocytosis, is activated upon phosphorylation by protein kinase C (PKC) and proline-directed protein kinases. In Alzheimer disease (AD), activated microglia expressing MARCKS migrates around senile plaques. We...


    pub_type: 杂志文章


    authors: Hasegawa H,Nakai M,Tanimukai S,Taniguchi T,Terashima A,Kawamata T,Fukunaga K,Miyamoto E,Misaki K,Mukai H,Tanaka C

    更新日期:2001-08-08 00:00:00

  • Neuroprotective effects of 17β-estradiol associate with KATP in rat brain.

    abstract::Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...


    pub_type: 杂志文章


    authors: Zhang D,Xia H,Xu L,Zhang C,Yao W,Wang Y,Ren J,Wu J,Tian Y,Liu W,Wang X

    更新日期:2012-11-14 00:00:00

  • Effect of insulin on spatial memory in aluminum chloride-induced dementia in rats.

    abstract::Latest reports suggest the involvement of insulin in modulating memory. A few published in-vitro studies favor the antidementia effect of insulin. Thus, the present study aimed to evaluate the prophylactic role of insulin and its combination with glucose and its possible mechanism(s) in an aluminum chloride (AlCl3)-in...


    pub_type: 杂志文章


    authors: Nampoothiri M,Kumar N,Venkata Ramalingayya G,Gopalan Kutty N,Krishnadas N,Mallikarjuna Rao C

    更新日期:2017-06-14 00:00:00

  • Effects of bromocriptine on human subjects depend on working memory capacity.

    abstract::Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cogniti...


    pub_type: 杂志文章


    authors: Kimberg DY,D'Esposito M,Farah MJ

    更新日期:1997-11-10 00:00:00

  • Neural basis of syntactic processing of simple sentences in Japanese.

    abstract::This study used event-related functional magnetic resonance imaging to investigate the neural basis underlying the sequential involvement of syntactic processing in the course of sentence comprehension. In experiments, a noun, case particle, and verb were presented one by one, constituting simple sentences in Japanese...


    pub_type: 杂志文章


    authors: Ogawa K,Ohba M,Inui T

    更新日期:2007-09-17 00:00:00

  • Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.

    abstract::The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation, nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p5...


    pub_type: 杂志文章


    authors: Zhou J,Fu Y,Tang XC

    更新日期:2001-07-20 00:00:00

  • Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.

    abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...


    pub_type: 杂志文章


    authors: Chen Y,Getchell ML,Ding X,Getchell TV

    更新日期:1992-09-01 00:00:00

  • Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself.

    abstract::We earlier showed that leucine-rich glioma inactivated 3 (LGI3) colocalizes with amyloid beta peptide (Abeta) taken up by astrocytes both in vitro and in vivo, and that LGI3 accumulated with endocytosis-associated proteins in aged monkey brains. In this study, we confirmed that LGI3 localizes to the endocytic pathway ...


    pub_type: 杂志文章


    authors: Okabayashi S,Kimura N

    更新日期:2008-08-06 00:00:00

  • Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity.

    abstract::Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....


    pub_type: 杂志文章


    authors: Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

    更新日期:2007-03-26 00:00:00