Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

abstract：:An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...

journal_title：Neuroreport

authors： Li HY,Wang LL,Yeh RS

更新日期：1999-02-05 00:00:00

abstract：:To test for the feature specificity of adaptation of auditory-cortex magnetoencephalographic N1m responses to phonemes during lipreading, we presented eight healthy volunteers with a simplified sine-wave first-formant (F1) transition shared by /ba/, /ga/, and /da/, and a continuum of second-formant (F2) transitions co...

journal_title：Neuroreport

authors： Jääskeläinen IP,Kauramäki J,Tujunen J,Sams M

更新日期：2008-01-08 00:00:00

abstract：:In the visual modality adaptation to high temporal frequency can result in spatially localized apparent duration compression. The principal point of adaptation is thought to be early in the visual system, at which point temporal information is encoded within sustained (parvocellular) and transient (magnocellular) chan...

journal_title：Neuroreport

authors： Watanabe J,Amemiya T,Nishida S,Johnston A

更新日期：2010-09-15 00:00:00

abstract：:4-Aminobenzovesamicol was used to test whether activation of protein kinase C protects the vesicular acetylcholine transporter from interaction with vesamicol-like drugs. The essentially irreversible vesamicol analog inhibits the release of newly synthesized [3H]acetylcholine from stimulated hippocampal slices. Prior ...

journal_title：Neuroreport

authors： Clarizia AD,Gomez MV,Romano-Silva MA,Parsons SM,Prado VF,Prado MA

更新日期：1999-09-09 00:00:00

abstract：:Removal of the labyrinthine organs on one side results in static and dynamic disturbances. Some functional recovery occurs over time and is paralleled in frogs by an increase in the efficacy of central vestibular pathways. Here, we report concomitant increases in dorsal root evoked ventral root responses in the brachi...

journal_title：Neuroreport

authors： Straka H,Kunkel A,Dieringer N

更新日期：1993-09-01 00:00:00

abstract：:Eleven early-onset dementia families, all with affected individuals who have either presented clinical symptoms of early onset familial Alzheimer's disease (EOFAD) or have been confirmed to have EOFAD by autopsy, and two early onset cases with biopsy-confirmed AD pathology, were screened for missense mutations in the ...

journal_title：Neuroreport

authors： Kwok JB,Taddei K,Hallupp M,Fisher C,Brooks WS,Broe GA,Hardy J,Fulham MJ,Nicholson GA,Stell R,St George Hyslop PH,Fraser PE,Kakulas B,Clarnette R,Relkin N,Gandy SE,Schofield PR,Martins RN

更新日期：1997-04-14 00:00:00

abstract：:Event-related brain potential studies show that negative feedback in guessing tasks elicits a medial frontal negativity. Most theory and experimentation concerning this feedback-related negativity (FRN) has assumed that the FRN has little relationship to the perceptual characteristics of the feedback. This study chall...

journal_title：Neuroreport

authors： Liu Y,Gehring WJ

更新日期：2009-04-22 00:00:00

abstract：:Blockade of L-type Ca2+ channels results in a decrease in firing frequency of neostriatal neurons. In contrast, N- and P/Q-types of Ca2+ channel cooperate to tune firing pattern, since both of these channel types have to be blocked to enhance firing frequency. Parameters of the intensity-frequency plot were differenti...

journal_title：Neuroreport

authors： Pérez-Garci E,Bargas J,Galarraga E

更新日期：2003-07-01 00:00:00

abstract：:Synaptic vesicles contain a protein (agglutinin) which binds cell plasma membranes. The protein activity is titrated measuring the agglutination of rabbit trypsinized-fixed red blood cells induced by serial dilutions of purified vesicles. The protein is highly concentrated in vesicles: the specific activity is 150-fol...

journal_title：Neuroreport

authors： Popoli M,Paterno R

更新日期：1991-02-01 00:00:00

abstract：:It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...

journal_title：Neuroreport

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：1998-08-03 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays critical roles in neurotransmission, synaptic plasticity, learning and memory. The aim of this study was to examine, by in situ hybridization, prefrontal cortical expression of CaMKII alpha mRNA in postmortem brains of unipolar, bipolar, schizophrenic, and con...

journal_title：Neuroreport

authors： Xing G,Russell S,Hough C,O'Grady J,Zhang L,Yang S,Zhang LX,Post R

更新日期：2002-03-25 00:00:00

abstract：:The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategi...

journal_title：Neuroreport

authors： Frick KM,Stillner ET,Berger-Sweeney J

更新日期：2000-11-09 00:00:00

abstract：:The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...

journal_title：Neuroreport

authors： Chen J,Zhang S,Zuo P,Tang L

更新日期：1997-05-06 00:00:00

abstract：:Chimeric mice stably reconstituted with bone marrow cells represent a good model for analysis of the mechanism of bone marrow cell infiltration in the brain. However, in preparing chimeric mice, irradiation of the recipient mice is necessary to kill their own bone marrow before transplantation, which induces gliosis a...

journal_title：Neuroreport

authors： Furuya T,Tanaka R,Urabe T,Hayakawa J,Migita M,Shimada T,Mizuno Y,Mochizuki H

更新日期：2003-03-24 00:00:00

abstract：:In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...

journal_title：Neuroreport

authors： Yamada M,Takahashi K,Ukai W,Hashimoto E,Saito T,Yamada M

更新日期：2010-01-27 00:00:00

abstract：:We investigated the cardiovascular effects of bilateral microinjection of antisense oligodeoxynucleotides (oligos) into the nucleus tractus solitarii (NTS) to neuronal nitric oxide synthase (nNOS) to suppress the expression of nNOS molecular biologically. In urethane-anesthetized, paralyzed Wistar-Kyoto rats, bilatera...

journal_title：Neuroreport

authors： Maeda M,Hirano H,Kudo H,Doi Y,Higashi K,Fujimoto S

更新日期：1999-06-23 00:00:00

abstract：:The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to fla...

journal_title：Neuroreport

authors： Sakai H,Saito T

更新日期：1994-04-14 00:00:00

abstract：:Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...

journal_title：Neuroreport

authors： Suzuki K,Okuda J,Otsuka Y,Sugawara A,Hatanaka K,Nakasato N,Kanno A,Yoshimoto T,Fujii T,Yamadori A

更新日期：2001-02-12 00:00:00

abstract：:In the anaesthetized rat, low frequency electrical stimulation of the Zusanli acupoint (S36) or noxious thermal stimulation caused by immersing the footpad in water at 52 degrees C caused marked expression of c-fos in the anterior lobe of the pituitary gland, as well as in the arcuate and some nearby hypothalamic nucl...

journal_title：Neuroreport

authors： Pan B,Castro-Lopes JM,Coimbra A

更新日期：1994-08-15 00:00:00

abstract：:The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis. We measured...

journal_title：Neuroreport

authors： Gatta LB,Albertini A,Ravid R,Finazzi D

更新日期：2002-11-15 00:00:00

abstract：:In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...

journal_title：Neuroreport

authors： Jung RE,Yeo RA,Chiulli SJ,Sibbitt WL Jr,Weers DC,Hart BL,Brooks WM

更新日期：1999-11-08 00:00:00

abstract：:Expression of the lipophilic ligand transporter, apolipoprotein D (apoD) by primary astrocyte cultures derived from neonatal mouse brain was investigated. Western blot analysis of cell lysates and media showed that apoD is constitutively secreted by astrocytes with little intracellular storage. The secreted apoD float...

journal_title：Neuroreport

authors： Patel SC,Asotra K,Patel YC,McConathy WJ,Patel RC,Suresh S

更新日期：1995-03-07 00:00:00

abstract：:Transplantation of olfactory ensheathing cells (OECs) into photochemically damaged rat spinal cord diminished astrocyte reactivity and parenchyma cavitation. The photochemical lesion performed at T12--L1 resulted in severe damage to the spinal cord, so that during the first 15 days postoperation all rats dragged their...

journal_title：Neuroreport

authors： Verdú E,García-Alías G,Forés J,Gudiño-Cabrera G,Muñetón VC,Nieto-Sampedro M,Navarro X

更新日期：2001-08-08 00:00:00

abstract：:GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium s...

journal_title：Neuroreport

authors： Rovira C,Ben-Ari Y

更新日期：1994-10-27 00:00:00

abstract：:ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...

journal_title：Neuroreport

authors： Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro N

更新日期：2004-09-15 00:00:00

abstract：:Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...

journal_title：Neuroreport

authors： Menon V,Ford JM,Lim KO,Glover GH,Pfefferbaum A

更新日期：1997-09-29 00:00:00

abstract：:To determine whether EEG synchronization in sleep has a metabolic equivalent, we investigated state-dependent changes in extracellular concentrations of amino acids. In vivo microdialysis studies were performed in the ventroposterolateral (VPL) nuclei of the thalamus of cats during natural slow wave sleep (SWS), wakin...

journal_title：Neuroreport

authors： Kékesi KA,Dobolyi A,Salfay O,Nyitrai G,Juhász G

更新日期：1997-03-24 00:00:00

abstract：:Although the self-referential effect was widely supported by several previous studies, there was few event-related potential (ERP) evidence for the encoding mechanism of the self-referential effect. The present study employed ERPs to investigate whether the electrophysiological indices of the encoding processing could...

journal_title：Neuroreport

authors： Yang X,Mao X,Han M,Li X,Guo C

更新日期：2019-09-04 00:00:00

abstract：:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microi...

journal_title：Neuroreport

authors： Lee JW,Kim WY,Kim JH

更新日期：2018-04-11 00:00:00

abstract：:Musical expertise has been shown to induce widespread structural and functional alterations in the brain, even-handedly affecting top-down and bottom-up factors. At the same time, it is known that the early evoked gamma-band response (GBR) can be modulated by top-down as well as bottom-up factors such as attention and...

journal_title：Neuroreport

authors： Ott CG,Stier C,Herrmann CS,Jäncke L

更新日期：2013-06-19 00:00:00