Abstract:
:In the present study the effects of intracerebroventricular (ICV) administration of baclofen (0.1-5.0 nmol) was investigated on food intake in non-fasted rats. Baclofen (1.0, 2.5 and 5.0 nmol) increased food consumption in a dose-related manner during the first 15-30 min after administration. The effects of baclofen (5.0 nmol) on feeding were prevented by pretreating the rats with the specific GABA-B receptor antagonist phaclofen (40 nmol, ICV). These results suggest that baclofen increases food intake in rats by an action at central GABA-B receptors.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ebenezer ISdoi
10.1097/00001756-199009000-00020subject
Has Abstractpub_date
1990-09-01 00:00:00pages
73-6issue
1eissn
0959-4965issn
1473-558Xjournal_volume
1pub_type
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