Role of nitric oxide in 2-deoxy-D-glucose-induced hypothermia in rats.

Abstract:

:The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibitor) or both treatments together. We observed a significant reduction in body temperature after 2-DG injection. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, a reduction in the magnitude of 2-DG-induced hypothermia was observed. The neuronal NOS inhibitor 7-nitroindazole also inhibited 2-DG-induced hypothermia. The data indicate that NO, probably produced by neuronal NOS, plays a role in 2-DG-induced hypothermia.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Carnio EC,Almeida MC,Fabris G,Branco LG

doi

10.1097/00001756-199909290-00041

subject

Has Abstract

pub_date

1999-09-29 00:00:00

pages

3101-4

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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