Abstract:
:The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in 2-deoxy-D-glucose (2-DG)-induced hypothermia. The body temperature of awake, unrestrained rats was measured before and after the administration of 2-DG, or N(G)-nitro-L-arginine methyl ester (L-NAME; a non-selective NOS inhibitor) or both treatments together. We observed a significant reduction in body temperature after 2-DG injection. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, a reduction in the magnitude of 2-DG-induced hypothermia was observed. The neuronal NOS inhibitor 7-nitroindazole also inhibited 2-DG-induced hypothermia. The data indicate that NO, probably produced by neuronal NOS, plays a role in 2-DG-induced hypothermia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Carnio EC,Almeida MC,Fabris G,Branco LGdoi
10.1097/00001756-199909290-00041subject
Has Abstractpub_date
1999-09-29 00:00:00pages
3101-4issue
14eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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