Abstract:
:Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 76), indicating the presence of active purinergic metabotropic receptors in about 59% of neurones. [Ca2+]i transients induced by 2MeSATP in Ca2+-free external solution were completely abolished by 10 microM PPADS, indicating that some of the corresponding receptors are of the P2Y1 type. In acutely isolated neurones which lost their dendrites, there were no metabotropic response. The results confirm the presence of metabotropic postsynaptic purinoreceptors located in the dendritic tree of dorsal horn neurones.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kruglikov I,Shutov L,Potapenko E,Voitenko N,Kostyuk Pdoi
10.1097/00001756-200111160-00026subject
Has Abstractpub_date
2001-11-16 00:00:00pages
3503-7issue
16eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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