Immunohistochemical study of the hnRNP A2 and B1 in the rat forebrain.

Abstract:

:Immunohistochemical techniques were employed to examine the distribution of RNA-binding proteins A2 and B1 in the rat forebrain. Intense A2 and B1 immunolabeling were observed in the nucleoplasm of the neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamen as well as the supraoptic nucleus of hypothalamus. In contrast, within the bed nucleus of the stria terminalis, as well as the medial and lateral habenular nucleus of thalamus, immunoreactivity for both proteins was weak. Within the globus pallidus and thalamic nucleus immunoreactivity for A2 was hardly detectable despite of intense B1 immunolabeling, while within the endopiriform nucleus and lateral and basolateral nucleus of amygdala intensity of B1 immunolabeling was relatively weak compared to A2. Our study suggests that the distribution of A2 and B1 are not constant throughout the forebrain and this diversity may reflect the post-transcriptional regulation of cell-specific gene expression of neuronal cells.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Mizukami K,Kamma H,Ishikawa M,Dreyfuss G

doi

10.1097/00001756-200009280-00012

subject

Has Abstract

pub_date

2000-09-28 00:00:00

pages

3099-102

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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