Ultrastructural localization of activated NF-kappaB in granule cells of the rat fascia dentata.

Abstract:

:The distribution of activated NF-kappaB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-kappaB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in proximal dendrites, somata, and nuclei but not in axon terminals of granule cells. Within the nuclei of granule cells, clusters of NF-kappaB immunoreactivity were detected. These data are in line with the proposed function of NF-kappaB as a retrograde signal transducer which transports information from synaptic sites to the nucleus to initiate gene expression.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kaltschmidt B,Deller T,Frotscher M,Kaltschmidt C

doi

10.1097/00001756-200003200-00036

subject

Has Abstract

pub_date

2000-03-20 00:00:00

pages

839-44

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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