Abstract:
:The distribution of activated NF-kappaB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-kappaB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in proximal dendrites, somata, and nuclei but not in axon terminals of granule cells. Within the nuclei of granule cells, clusters of NF-kappaB immunoreactivity were detected. These data are in line with the proposed function of NF-kappaB as a retrograde signal transducer which transports information from synaptic sites to the nucleus to initiate gene expression.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kaltschmidt B,Deller T,Frotscher M,Kaltschmidt Cdoi
10.1097/00001756-200003200-00036subject
Has Abstractpub_date
2000-03-20 00:00:00pages
839-44issue
4eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract:OBJECTIVE:We sought to determine whether cortical excitability, measured via transcranial magnetic stimulation (TMS), is associated with cognition in healthy individuals and whether gender and education have an impact on this relationship. METHODS:Fifty-four healthy individuals (31 males, mean age = 41.94, SD = 21.98;...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001392
更新日期:2020-03-04 00:00:00
abstract::We present the first assessment of motion vision in childhood autism. Postural reactivity to visually perceived motion was measured in five autistic children and 12 normal controls of the same chronological age. Anteroposterior as well as total body sway occurring on a force platform in response to movements in the vi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00034
更新日期:1995-05-30 00:00:00
abstract::Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00027
更新日期:2002-07-02 00:00:00
abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00026
更新日期:2003-12-02 00:00:00
abstract::The presence and regulation of pituitary adenylate cyclase activating peptide (PACAP) was investigated in the adult rat superior cervical ganglion. Double-labelling immunofluorescence using specific antibodies against PACAP and vasoactive intestinal peptide (VIP) revealed a dense innervation of postganglionic sympathe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00078
更新日期:1996-11-04 00:00:00
abstract::Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002070-00041
更新日期:2000-02-07 00:00:00
abstract::Humans afflicted with mood disorders respond differently to antidepressant drug therapy. Different responses to psychoactive drugs are also observed in rats, and specific strains exhibit substantial differences in gene expression following synaptic activity. We examined the effects of fluoxetine on the induction of Fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212200-00018
更新日期:2002-12-20 00:00:00
abstract::Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001215
更新日期:2019-04-10 00:00:00
abstract::The conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinki...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00038
更新日期:1998-08-24 00:00:00
abstract::Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328333b0e0
更新日期:2009-12-09 00:00:00
abstract::Transcranial direct current stimulation (tDCS) was used in 17 normal individuals to modulate vestibulo-ocular reflex (VOR) and self-motion perception rotational thresholds. The electrodes were applied over the temporoparietal junction bilaterally. Both vestibular nystagmic and perceptual thresholds were increased duri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283646e65
更新日期:2013-10-02 00:00:00
abstract::We evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-administrate cocaine (0.5 mg/kg) or saline during 10 daily sessions. MK-801 (0.1-0.25...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00014
更新日期:1998-03-09 00:00:00
abstract::DNA fragmentation, the hallmark of apoptosis, has been recently investigated with contradictory results in several skeletal muscle disorders. Using in situ labeling of nuclear DNA fragmentation, we have tested the possibility that apoptosis might occur in muscles from patients with mitochondrial respiratory chain defe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199807130-00050
更新日期:1998-07-13 00:00:00
abstract::Familial Alzheimer's disease due to presenilin 1 (PSEN1) mutations shows considerable phenotypic variability with differences in neuropathology and neurological symptoms. Spastic paraparesis is a common neurological phenotype associated with Alzheimer's disease arising from PSEN1 mutations. To investigate whether know...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282405209
更新日期:2007-08-06 00:00:00
abstract::In this study, we determined whether the visuospatial attention network of frontal, parietal, and occipital cortex can be parsed into two different subsets of active regions associated with transient and sustained processes within the same cue-to-target delay period of an endogenously cued visuospatial attention task....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f4a14f
更新日期:2008-01-22 00:00:00
abstract::Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or se...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507310-00005
更新日期:1995-07-31 00:00:00
abstract::The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000492
更新日期:2016-01-20 00:00:00
abstract::The present study examined cerebral representations of Japanese long and short vowel categories with near-infrared spectroscopy (NIRS) by measuring the hemodynamic changes. Results showed that NIRS could capture phoneme-specific information. The left side of the auditory area showed large hemodynamic changes only for ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200204160-00009
更新日期:2002-04-16 00:00:00
abstract::The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onse...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199108000-00016
更新日期:1991-08-01 00:00:00
abstract::Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly 10% of the population. At present there is no cure for this disorder but gene therapy has been suggested as a potentially effective method for clinical treatment in the future. Thus we investigated the effectiveness of adenovira...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207190-00016
更新日期:2002-07-19 00:00:00
abstract::Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract::Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00009
更新日期:2001-10-08 00:00:00
abstract::Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00002
更新日期:1997-11-10 00:00:00
abstract::Inhibitory deficits are one of the predominant causes of cognitive aging. This study examined age-related changes in response inhibition. In this study, young and older participants performed a bimanual/bipedal response inhibition task while we measured their brain activity via functional near-infrared spectroscopy. P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001516
更新日期:2020-10-07 00:00:00
abstract::Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911080-00024
更新日期:1999-11-08 00:00:00
abstract::Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199807130-00020
更新日期:1998-07-13 00:00:00
abstract::The immediate-early genes, especially c-fos, have been suggested to have an important role in neuronal plasticity and memory. However, it has been difficult to determine if in fact c-fos can participate in control of behaviour. Here we can report that direct unilateral infusion into the rat neostriatum of an antisense...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00024
更新日期:1993-12-13 00:00:00
abstract::Segmental ligation of spinal nerves in the rat induces a long-lasting hyperalgesia and allodynia that mimicks neuropathic conditions in humans. In the present study we attempted to determine whether supraspinal NMDA receptors contribute to the induction of the long-lasting hypersensitivity to noxious and innocuous mec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909290-00011
更新日期:1999-09-29 00:00:00
abstract::The study aimed to investigate the time-course of electromagnetic field (EMF)-induced effects on human cognitive and behavioral performance and on tympanic temperature. Subjects were randomly assigned to two groups, exposed to a 902.40 MHz EMF before the testing session, or to the same signal during the data collectin...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200401190-00031
更新日期:2004-01-19 00:00:00
abstract::Capsaicin in the adult animal causes antinociception due to the massive release of neurotransmitters, including substance P (SP), from primary afferent C-fibers. The results of the present study indicate that capsaicin-induced antinociception in the adult is sensitive to inhibition by dizocilpine (MK-801). The failure...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00