Abstract:
:We studied the involvement of norepinephrine in the medial prefrontal cortex in the rewarding/reinforcing effects of ethanol. We evaluated the effects of norepinephrine selective depletion in the medial prefrontal cortex of C57/BL6J inbred mice that are commonly used in molecular studies and are highly susceptible to the behavioral effects of ethanol. In mice with prefrontal norepinephrine depletion, ethanol did not induce conditioned place preference, and a clear-cut reduction of ethanol consumption and preference was evident. These results indicate that prefrontal norepinephrine transmission is a critical factor in the rewarding/reinforcing effects of ethanol.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ventura R,De Carolis D,Alcaro A,Puglisi-Allegra Sdoi
10.1097/01.wnr.0000239964.83566.75subject
Has Abstractpub_date
2006-11-27 00:00:00pages
1813-7issue
17eissn
0959-4965issn
1473-558Xpii
00001756-200611270-00012journal_volume
17pub_type
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