Ethanol consumption and reward depend on norepinephrine in the prefrontal cortex.

Abstract:

:We studied the involvement of norepinephrine in the medial prefrontal cortex in the rewarding/reinforcing effects of ethanol. We evaluated the effects of norepinephrine selective depletion in the medial prefrontal cortex of C57/BL6J inbred mice that are commonly used in molecular studies and are highly susceptible to the behavioral effects of ethanol. In mice with prefrontal norepinephrine depletion, ethanol did not induce conditioned place preference, and a clear-cut reduction of ethanol consumption and preference was evident. These results indicate that prefrontal norepinephrine transmission is a critical factor in the rewarding/reinforcing effects of ethanol.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Ventura R,De Carolis D,Alcaro A,Puglisi-Allegra S

doi

10.1097/01.wnr.0000239964.83566.75

subject

Has Abstract

pub_date

2006-11-27 00:00:00

pages

1813-7

issue

17

eissn

0959-4965

issn

1473-558X

pii

00001756-200611270-00012

journal_volume

17

pub_type

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