Abstract:
:Maintaining genomic integrity is vital for cell survival and homeostasis. Mutations in critical genes in germ-line and somatic cells are often implicated with the onset or progression of diseases. DNA repair enzymes thus take important roles as guardians of the genome in the cell. Besides the known function to repair DNA damage, recent findings indicate that DNA repair enzymes regulate the transcription of protein-coding and noncoding RNA genes. In particular, a novel role of DNA damage response signaling has been identified in the regulation of transcriptional elongation. Topoisomerases-mediated DNA breaks appear important for the regulation. In this review, recent findings of these DNA break- and repair-associated enzymes in transcription and potential roles of transcriptional activation-coupled DNA breaks are discussed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Bunch Hdoi
10.1002/1873-3468.12152subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1064-75issue
8eissn
0014-5793issn
1873-3468journal_volume
590pub_type
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