Grapefruit: the last decade acquisitions.

abstract：:Three undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) and three tocotrienols derivatives, named as paucinochymol A-F (1-3 and 10-12), together with six known PPAPs, were isolated from the fruits of Garcinia paucinervis. Their structures and absolute configurations were determined by extensive NMR ana...

journal_title：Fitoterapia

authors： Tan X,Zhong F,Teng H,Li Q,Li Y,Mei Z,Chen Y,Yang G

更新日期：2020-10-01 00:00:00

abstract：:Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were ...

journal_title：Fitoterapia

authors： Yuan CM,Tang GH,Wang XY,Zhang Y,Cao MM,Li XH,Li Y,Li SL,Di YT,He HP,Hao XJ,Hua HM

更新日期：2013-10-01 00:00:00

abstract：:Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...

journal_title：Fitoterapia

authors： Sequeiros C,López LM,Caffini NO,Natalucci CL

更新日期：2003-09-01 00:00:00

abstract：:Sarcandracoumarin (1), the first coumarin having a 1-phenylethyl substituent at the C-3 position, was isolated along with eleven known phenolic compounds from the water extract of Sarcandra glabra. Its structure was elucidated on the basis of spectroscopic data. Compound 1 exhibited moderate or weak cytotoxicity again...

journal_title：Fitoterapia

authors： Feng S,Xu L,Wu M,Hao J,Qiu SX,Wei X

更新日期：2010-09-01 00:00:00

abstract：:A simple, sensitive and accurate liquid chromatographic method with photodiode-array detection was developed for determination of dehydroevodiamine with detection wavelength at 368 nm and column temperature at 30 degrees C. The separation was carried out on an Agilent Zorbax SB-C(18) column (250 mm x 4.6 mm, 5 microm)...

journal_title：Fitoterapia

authors： Zhao Y,Zhou X,Chen HG,Gong XJ,Cai ZW,Zhou CY

更新日期：2009-10-01 00:00:00

abstract：:The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines. We show that it further modulates the Nrf2 homolog SKN-1 in Caenorhabditis elegans and by this pathway mediates beneficial effects in the nematode: baicalein enhances the resistance of C. elegans ...

journal_title：Fitoterapia

authors： Havermann S,Humpf HU,Wätjen W

更新日期：2016-09-01 00:00:00

abstract：:A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cerv...

journal_title：Fitoterapia

authors： Dat NT,Binh PT,Quynh le TP,Van Minh C,Huong HT,Lee JJ

更新日期：2010-12-01 00:00:00

abstract：:A new diterpenoid ester, fritillahupehin (1) together with three known fatty acids: palmitic acid (2), lignoceric acid (3) and azelaic acid (4) were isolated from the bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. The structure of fritillahupehin has been established to be ent-kauran-16beta-yl lignocerate by mea...

journal_title：Fitoterapia

authors： Ruan H,Zhang Y,Wu J,Deng S,Sun H,Fujita T

更新日期：2002-07-01 00:00:00

abstract：:The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appra...

journal_title：Fitoterapia

authors： Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YG

更新日期：2019-04-01 00:00:00

abstract：:Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Polyozellin, a major constituent of a Korea edible mushroo...

journal_title：Fitoterapia

authors： Lee W,Yang EJ,Park DH,Bae JS

更新日期：2016-01-01 00:00:00

abstract：:The antinociceptive properties of the aqueous extract of Eupatorium buniifolium aerial parts were investigated in chemical and thermal models of nociception in mice. Oral doses of 250 and 500 mg/kg produced an inhibition of 42.3% and 73.9%, respectively, of the abdominal writhes induced by acetic acid in mice. This an...

journal_title：Fitoterapia

authors： Miño J,Muschietti L,Ferraro G,Martino V,Acevedo C

更新日期：2005-01-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:A sensitive and specific HPLC method was developed to analyze baicalin in rat plasma. The author had compared the pharmacokinetics of baicalin after oral administration of HLJDT decoction or pure baicalin in MCAO and sham-operated rats. All the rats were divided into two groups, MCAO and sham-operated rats. Each group...

journal_title：Fitoterapia

authors： Zeng MF,Pan LM,Zhu HX,Zhang QC,Guo LW

更新日期：2010-09-01 00:00:00

abstract：:Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type c...

journal_title：Fitoterapia

authors： Zhang Y,Cao Y,Wang Q,Zheng L,Zhang J,He L

更新日期：2011-10-01 00:00:00

abstract：:Five new cytochalasans (1-5) were isolated from the rice fermentation of fungus Xylaria longipes, along with seven known compounds cytochalasin P (6), cytochalasin D (7), zygosporin D (8), 7-O-acetylcytochalasin D (9), cytochalasin C (10), 6,7-dihydro-7-oxo-cytochalasin C (11), and 6,7-dihydro-7-oxo-deacetylcytochalas...

journal_title：Fitoterapia

authors： Wang WX,Li ZH,He J,Feng T,Li J,Liu JK

更新日期：2019-09-01 00:00:00

abstract：:The isolation of five flavonol glycosides (1-5) from the flowers of Aconitum vulparia is reported, together with the 1H- and 13C-NMR spectral data in CD(3)OD of compound 3 and 5. ...

journal_title：Fitoterapia

authors： Fico G,Braca A,Morelli I,Tomè F

更新日期：2003-06-01 00:00:00

abstract：:Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative...

journal_title：Fitoterapia

authors： Kedzierska M,Olas B,Wachowicz B,Glowacki R,Bald E,Czernek U,Szydłowska-Pazera K,Potemski P,Piekarski J,Jeziorski A

更新日期：2012-03-01 00:00:00

abstract：:Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirm...

journal_title：Fitoterapia

authors： Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DA

更新日期：2010-12-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...

journal_title：Fitoterapia

authors： Li Q,Zhu Q,Zhang X,Hua C,Deng X,Zhao T,Sun B

更新日期：2013-10-01 00:00:00

abstract：:In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures o...

journal_title：Fitoterapia

authors： Cao L,Li B,Shehla N,Gong LM,Jian YQ,Peng CY,Sheng WB,Liu LP,Cai X,Man RY,Liao DF,Zhu XQ,Choudhary MI,Rahman AU,Wang W

更新日期：2020-01-01 00:00:00

abstract：:There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to ang...

journal_title：Fitoterapia

authors： He YL,Shi JY,Peng C,Hu LJ,Liu J,Zhou QM,Guo L,Xiong L

更新日期：2018-07-01 00:00:00

abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...

journal_title：Fitoterapia

authors： Zhang L,Wang H,Fan H,Wang T,Jiang N,Yu P,Fu F

更新日期：2011-09-01 00:00:00

abstract：:Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was d...

journal_title：Fitoterapia

authors： Yang YL,Li W,Wang H,Yang L,Yuan JZ,Cai CH,Chen HQ,Dong WH,Ding XP,Jiang B,Mándi A,Kurtán T,Mei WL,Dai HF

更新日期：2019-10-01 00:00:00

abstract：:Hydroxycinnamic acid amides of serotonin (HCAAS) [caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radi...

journal_title：Fitoterapia

authors： Choi JY,Kim H,Choi YJ,Ishihara A,Back K,Lee SG

更新日期：2010-12-01 00:00:00

abstract：:Diabetes is a worldwide healthy concern, which affects approximately 9% of the population. Tetrahydrocurcumin (THC) is the main metabolite of curcumin, which exerts the anti-diabetic activity. However, the underlying mechanism has not been clarified. In the research, we investigated whether THC could improve diabetes ...

journal_title：Fitoterapia

authors： Yuan T,Yin Z,Yan Z,Hao Q,Zeng J,Li L,Zhao J

更新日期：2020-10-01 00:00:00

abstract：:This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice. Cis-mulberroside A (25 and 50mg/kg) given by p.o. route 30 min before challenge produced a dose-dependent inhibition of the acetic acid-induced pain and Evans...

journal_title：Fitoterapia

authors： Zhang Z,Shi L

更新日期：2010-04-01 00:00:00

abstract：:Soluble proteins from the latex of Calotropis procera (LP) were investigated in vitro and in vivo for digestibility as the latex has previously been shown to produce considerable toxic effects on animals. The latex is also an important biologically active compound that displays antiinflammatory and antidiarrhea proper...

journal_title：Fitoterapia

authors： Ramos MV,Aguiar VC,da Silva Xavier AA,Lima MW,Bandeira GP,Etchells JP,Nogueira NA,Alencar NM

更新日期：2006-06-01 00:00:00

abstract：:Aloe barbadensis Mill has been used as food and medicine for a long time. In order to investigate the chemical constituents of A. barbadensis and their inhibitory activities towards phosphodiesterase-4D (PDE4D), 70% methanol extract of the dried A. barbadensis powder was employed. Phytochemical investigation has led t...

journal_title：Fitoterapia

authors： Zhong J,Huang Y,Ding W,Wu X,Wan J,Luo H

更新日期：2013-12-01 00:00:00

abstract：:A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of t...

journal_title：Fitoterapia

authors： Li G,Li X,Cao L,Zhang L,Shen L,Zhu J,Wang J,Si J

更新日期：2015-06-01 00:00:00

abstract：:Callus and differentiated shoots initiated from Solanum tuberosum L. on MS media containing BA, IAA, and Kin. Glycoalkaloids are produced in callus and shoots in concentrations higher than original tubers using HPLC. Callus methanolic extract had promising anticancer activity with low IC(50) values against human carci...

journal_title：Fitoterapia

authors： Al-Ashaal HA

更新日期：2010-09-01 00:00:00