Regeneration, in vitro glycoalkaloids production and evaluation of bioactivity of callus methanolic extract of Solanum tuberosum L.

Abstract:

:Callus and differentiated shoots initiated from Solanum tuberosum L. on MS media containing BA, IAA, and Kin. Glycoalkaloids are produced in callus and shoots in concentrations higher than original tubers using HPLC. Callus methanolic extract had promising anticancer activity with low IC(50) values against human carcinoma cell lines of breast, lymphoplastic leukemia, larynx, liver, cervix, colon, and brain, IC(50) (microg/mL) were 2.7, 3.7, 6, 6.7, 10, 13.6, and 22.3 respectively. Antioxidant capacity of the extract (76.4%) performed using ESR. Preliminary screening showed that the extract exhibited in vitro virucidal activity against Herpes simplex. The extract possessed in vitro schistomicidal and fasciolicidal activity.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Al-Ashaal HA

doi

10.1016/j.fitote.2010.03.001

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

600-6

issue

6

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00060-2

journal_volume

81

pub_type

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