Abstract:
:Two new alkaloids, named stenine A (1) and stenine B (2), along with the known compounds neostenine (3), stenine (4) and neotuberostemonine (5), were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1D- and 2D-NMR spectra and X-ray single-crystal diffraction experiment. Anti-acetylcholinesterase (AChE) activity of compounds 1-5 were also tested. Compounds 2 and 4 showed significant anti-acetylcholinesterase activities, with IC50 values of 2.1±0.2 μM and 19.8±2.5 μM, resp. The mode of AChE inhibition by Compound 2 (the most potential AChE inhibitor) was reversible and competitive. In addition, molecular modeling was performed to explore the binding mode of compound 2 with AChE.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Lai DH,Yang ZD,Xue WW,Sheng J,Shi Y,Yao XJdoi
10.1016/j.fitote.2013.06.010subject
Has Abstractpub_date
2013-09-01 00:00:00pages
257-64eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00164-0journal_volume
89pub_type
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