Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.

Abstract:

:Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compounds 2-4 and 6 structurally involved acyclic 1.3-diols, the uneasy configuration determinations of which were well carried out by double-derivation NMR methods. Compounds 1-10 were evaluated for their antibacterial and antifungal activities against five strains of human pathogenic microorganisms. Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6μg/mL, respectively.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Yang MH,Li TX,Wang Y,Liu RH,Luo J,Kong LY

doi

10.1016/j.fitote.2016.11.008

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

72-76

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(16)30237-4

journal_volume

116

pub_type

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