Abstract:
:Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compounds 2-4 and 6 structurally involved acyclic 1.3-diols, the uneasy configuration determinations of which were well carried out by double-derivation NMR methods. Compounds 1-10 were evaluated for their antibacterial and antifungal activities against five strains of human pathogenic microorganisms. Helvolic acid (7) showed potent inhibitory effects against Staphylococcus aureus and Pseudomonas aeruginosa with MIC (minimum inhibitory concentration) values of 5.8 and 4.6μg/mL, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Yang MH,Li TX,Wang Y,Liu RH,Luo J,Kong LYdoi
10.1016/j.fitote.2016.11.008subject
Has Abstractpub_date
2017-01-01 00:00:00pages
72-76eissn
0367-326Xissn
1873-6971pii
S0367-326X(16)30237-4journal_volume
116pub_type
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