Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze.

abstract：:The aim of the present research was to establish a comprehensive strategy to identify the metabolites of isoimperatorin after biotransformation with rat liver microsomes in vitro, and further describe metabolic kinetic characteristics of isoimperatorin and its main metabolites. Utilizing liquid chromatography with tim...

journal_title：Fitoterapia

authors： Chen TL,Zhang YB,Xu W,Kang TG,Yang XW

更新日期：2014-03-01 00:00:00

abstract：:A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as '...

journal_title：Fitoterapia

authors： Nalli M,Ortar G,Schiano Moriello A,Di Marzo V,De Petrocellis L

更新日期：2017-10-01 00:00:00

abstract：:Epiberberine, a natural protoberberine from Coptis chinensis Franch., is a potential alkaloid for the treatment of a variety of chronic diseases. The aim of this study is to summarize recent advances in the multiple and potential therapeutic effects of epiberberine. High-quality researches published in last two decade...

journal_title：Fitoterapia

authors： Liu L,Li J,He Y

更新日期：2020-11-01 00:00:00

abstract：:Five new guaiane-type sesquiterpenoids were obtained from the roots of Daphne genkwa. Their gross structures were established by extensive spectroscopic analyses. Attempts on the assignment of the relative configurations were unsuccessful when based on the NOESY correlations. Therefore, NMR chemical shift calculations...

journal_title：Fitoterapia

authors： Wang J,Ren Q,Zhang YY,Guo R,Lin B,Huang XX,Song SJ

更新日期：2019-10-01 00:00:00

abstract：:Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than pa...

journal_title：Fitoterapia

authors： Chen XX,Gao F,Wang Q,Huang X,Wang D

更新日期：2014-01-01 00:00:00

abstract：:Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytoto...

journal_title：Fitoterapia

authors： Dai SJ,Qu GW,Yu QY,Zhang DW,Li GS

更新日期：2010-10-01 00:00:00

abstract：:Six previously undescribed compounds, named monaxanthones A and B, monaphenol A, monathioamide A, monaprenylindole A, and monavalerolactone A, were isolated from the culture of a marine-sourced bacterium Pseudomonas sp. ZZ820R in rice medium. Their structures were elucidated based on the HRESIMS data, NMR and MS-MS sp...

journal_title：Fitoterapia

authors： Yi W,Ge ZW,Wu B,Zhang Z

更新日期：2020-06-01 00:00:00

abstract：:Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well a...

journal_title：Fitoterapia

authors： Jiang HL,Luo XH,Wang XZ,Yang JL,Yao XJ,Crews P,Valeriote FA,Wu QX

更新日期：2012-10-01 00:00:00

abstract：:Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening. While g...

journal_title：Fitoterapia

authors： Simmler C,Pauli GF,Chen SN

更新日期：2013-10-01 00:00:00

abstract：:The fruits of Piper tuberculatum Jacq yielded piperine S (1) and N-(12,13,14-trimethoxydihydrocinnamoyl)-delta(3)-piperidin-2-one (2). Their complete NMR analysis based on one- and two-dimensional experiments is reported. ...

journal_title：Fitoterapia

authors： de O Chaves MC,de F Júnior AG,de O Santos BV

更新日期：2003-02-01 00:00:00

abstract：:The isolation of a new flavan, 5,7,4'-trihydroxy-8-ethoxycarbonylflavan (1), from the root of Daphne odora var. atrocaulis is reported. ...

journal_title：Fitoterapia

authors： Zhang W,Zhang W,Li T,Liu R,Li H,Chen H

更新日期：2004-12-01 00:00:00

abstract：:Dichloromethane extract of propolis (DCME) originating from Pitcairn Island demonstrated potent cytotoxicity against triple-negative MDA-MB-231 human breast carcinoma cells. The results from MTT assay showed that DCME inhibits the growth of the cancer cells in a dose- and time-dependent manner and upon the cell growth...

journal_title：Fitoterapia

authors： Georgieva K,Trusheva B,Uzunova V,Stoyanova T,Valcheva V,Popova M,Tzoneva R,Bankova V

更新日期：2018-07-01 00:00:00

abstract：:The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml a...

journal_title：Fitoterapia

authors： Psotová J,Chlopcíková S,Miketová P,Simánek V

更新日期：2005-09-01 00:00:00

abstract：:There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to ang...

journal_title：Fitoterapia

authors： He YL,Shi JY,Peng C,Hu LJ,Liu J,Zhou QM,Guo L,Xiong L

更新日期：2018-07-01 00:00:00

abstract：:The methanolic extract of the Zanthoxylum rhetsa Roxb. stem bark, given by oral route to mice at doses of 250 and 500 mg/kg, significantly reduced the abdominal contraction induced by acetic acid and the diarrhoeal episodes induced by castor oil in mice. ...

journal_title：Fitoterapia

authors： Rahman MT,Alimuzzaman M,Ahmad S,Chowdhury AA

更新日期：2002-07-01 00:00:00

abstract：:A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis,...

journal_title：Fitoterapia

authors： de Novais LMR,de Arueira CCO,Ferreira LF,Ribeiro TAN,Sousa PT Jr,Jacinto MJ,de Carvalho MG,Judice WAS,Jesus LOP,de Souza AA,Torquato HFV,Paredes-Gamero EJ,Silva VC

更新日期：2019-01-01 00:00:00

abstract：:Four new triterpenoids, sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis. Based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [α]D), the structures of sweriyunnangenin A (1), sweriyunnanosides A (...

journal_title：Fitoterapia

authors： Cao TW,Geng CA,Jiang FQ,Ma YB,He K,Zhou NJ,Zhang XM,Zhou J,Chen JJ

更新日期：2013-09-01 00:00:00

abstract：:The flavonoid baicalein has been demonstrated to be an activator of the transcription factor Nrf2 in mammalian cell lines. We show that it further modulates the Nrf2 homolog SKN-1 in Caenorhabditis elegans and by this pathway mediates beneficial effects in the nematode: baicalein enhances the resistance of C. elegans ...

journal_title：Fitoterapia

authors： Havermann S,Humpf HU,Wätjen W

更新日期：2016-09-01 00:00:00

abstract：:StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells....

journal_title：Fitoterapia

authors： Mendieta JR,Fimognari C,Daleo GR,Hrelia P,Guevara MG

更新日期：2010-07-01 00:00:00

abstract：:The isolation of jusmicranthin (1), a novel lignan from Justicia neesii, is reported. Compound 1 represents a new class of angularly fused arylnaphthalides having a gamma-hydroxylactone unit. ...

journal_title：Fitoterapia

authors： Rajasekhar D,Subbaraju GV

更新日期：2000-09-01 00:00:00

abstract：:The aqueous root extract of Mimosa pudica dose dependently inhibited the hyaluronidase and protease activities of Indian snakes (Naja naja, Vipera russelii and Echis carinatus) venom. ...

journal_title：Fitoterapia

authors： Girish KS,Mohanakumari HP,Nagaraju S,Vishwanath BS,Kemparaju K

更新日期：2004-06-01 00:00:00

abstract：:Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative...

journal_title：Fitoterapia

authors： Kedzierska M,Olas B,Wachowicz B,Glowacki R,Bald E,Czernek U,Szydłowska-Pazera K,Potemski P,Piekarski J,Jeziorski A

更新日期：2012-03-01 00:00:00

abstract：:Solanum nigrum L. (also called as European black nightshade) has been traditionally used as folk medicine and food in some regions. Phytochemical investigations of the immature fruits of S. nigrum yielded five steroidal alkaloid glycosides (1-5), including an unprecedented nor-spirosolane type steroidal alkaloid with ...

journal_title：Fitoterapia

authors： Xiang L,Wang Y,Yi X,He X

更新日期：2019-09-01 00:00:00

abstract：:Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyse...

journal_title：Fitoterapia

authors： Lu Q,Zhang WY,Pan DB,Shi DF,Pang QQ,Li HB,Yao XJ,Yao ZH,Yu Y,Yao XS

更新日期：2019-04-01 00:00:00

abstract：:CTPS-01, a water-soluble polysaccharide, was obtained from the root of Cudrania tricuspidata and estimated to have an average molecular weight of 5.9 x 10(3) and to be composed of glucose residues, solely. It contains an average repeating unit of decasaccharide, having a backbone consisting of 1,4-linked alpha-D-gluco...

journal_title：Fitoterapia

authors： Shi L,Fu YL,Chen KS

更新日期：2007-06-01 00:00:00

abstract：:The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screen...

journal_title：Fitoterapia

authors： Lutz JA,Kulshrestha M,Rogers DT,Littleton JM

更新日期：2014-10-01 00:00:00

abstract：:A screening was conducted with 26 plants collected in the Brazilian southeast region, to identify plant extracts with antibacterial properties against Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. Initially, the agar diffusion method was employed. Then, those extracts prese...

journal_title：Fitoterapia

authors： Oliveira DF,Pereira AC,Figueiredo HC,Carvalho DA,Silva G,Nunes AS,Alves DS,Carvalho HW

更新日期：2007-02-01 00:00:00

abstract：:The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appra...

journal_title：Fitoterapia

authors： Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YG

更新日期：2019-04-01 00:00:00

abstract：:Natural products chemistry is the discipline that lies at the heart of modern pharmacognosy. The field encompasses qualitative and quantitative analytical tools that range from spectroscopy and spectrometry to chromatography. Among other things, modern research on crude botanicals is engaged in the discovery of the ph...

journal_title：Fitoterapia

authors： Betz JM,Brown PN,Roman MC

更新日期：2011-01-01 00:00:00

abstract：:Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of ...

journal_title：Fitoterapia

authors： Wang X,Shi GR,Liu YF,Li L,Chen RY,Yu DQ

更新日期：2017-04-01 00:00:00