Abstract:
:The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appraise the literature available to date for CPT distribution and the phytochemistry of these CPT-producing plants. Metabolite comparative analyses between the plants were also conducted for tracking of possible clues for CPT biosynthesis. Forty-three plant species in total were reported to possess CPT-producing capability, and one hundred twenty-five alkaloids classified into three major categories are summarized herein. Metabolite comparative analysis between these plants suggests the probability that the formation of the central intermediate for CPT biosynthesis has multiple origins. A more complete biogenetic reasoning for CPT and its structural homolog was delineated based on this fragmentary phytochemical evidence from a chemical point of view. Furthermore, an in-house compound database was constructed for further metabolomic analysis.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YGdoi
10.1016/j.fitote.2019.02.014subject
Has Abstractpub_date
2019-04-01 00:00:00pages
113-128eissn
0367-326Xissn
1873-6971pii
S0367-326X(18)32390-6journal_volume
134pub_type
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