Abstract:
:Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are two unusual megastigmanes structurally containing a 6/5 fused ring system. Compound 3 exhibits inhibition of nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 value of 53.7 ± 1.0 μM (positive control, dexamethasone, IC50 = 16.6 ± 0.8 μM).
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Su C,Qi B,Wang J,Ding N,Wu Y,Shi XP,Zhu ZX,Liu X,Wang XH,Zheng J,Tu PF,Shi SPdoi
10.1016/j.fitote.2018.02.017subject
Has Abstractpub_date
2018-06-01 00:00:00pages
123-128eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31707-0journal_volume
127pub_type
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