Abstract:
:A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as 'true' antagonists with IC50 values<5μM. Only few curcuminoids were able to modulate TRPV1 channels with EC50 and IC50 values ranging from 3.4 and 6.0μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Nalli M,Ortar G,Schiano Moriello A,Di Marzo V,De Petrocellis Ldoi
10.1016/j.fitote.2017.09.007subject
Has Abstractpub_date
2017-10-01 00:00:00pages
126-131eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31084-5journal_volume
122pub_type
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