Abstract：
:Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type calcium channel currents and intracellular calcium free ion rise was nearly disappeared when adding Imp. In addition, Imp displayed a chromatographic peak similar to nitrendipine and verapamil by the cell membrane chromatography, same results from protein-drug docking approaches. Hence, Imp target the L-type calcium channel, and may be used as a novel antihypertensive drug.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhang Y,Cao Y,Wang Q,Zheng L,Zhang J,He Ldoi
10.1016/j.fitote.2011.05.016subject
Has Abstractpub_date
2011-10-01 00:00:00pages
988-96issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(11)00145-6journal_volume
82pub_type
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