Abstract：
:Crocetin (5-20 microg/ml), quercetin (10-40 microg/ml), and cisplatin (60-180 microg/ml) used as a positive control drug, were tested against human rhabdomyosarcoma (RD) cells and African green monkey kidney (Vero) cells. The cell viability, morphological changes, and lactate dehydrogenase activity were assessed. RD cell growth was found to be inhibited dose dependently by the three tested compounds. Morphological observation by phase contrast microscopy revealed that both crocetin and quercetin caused intense damage only on the malignant (RD) cells, whereas mild toxic effect was seen with cisplatin also on normal (Vero) cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Jagadeeswaran R,Thirunavukkarasu C,Gunasekaran P,Ramamurty N,Sakthisekaran Ddoi
10.1016/s0367-326x(00)00138-6keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
395-9issue
4eissn
0367-326Xissn
1873-6971pii
S0367-326X(00)00138-6journal_volume
71pub_type
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