Abstract:
:Hydroxycinnamic acid amides of serotonin (HCAAS) [caffeoylserotonin (compound 1), p-coumaroylserotonin (compound 2), and feruloylserotonin (compound 3)] are secondary metabolites produced in plants. The aim of this study was to investigate the cytoprotective effects of HCAAS based on intracellular reactive oxygen radical (ROS) generation, lipid peroxidation, protein carbonylation, and phosphorylation of histone H2AX in H(2)O(2) treated-HepG2 and HaCaT cells. We have shown that HCAAS showed various strong antioxidant activities in hydrogen peroxide treated both cell lines, suggesting that these compounds may play as chemotherapeutic agents for preventing or reducing the oxidative stress-induced diseases.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Choi JY,Kim H,Choi YJ,Ishihara A,Back K,Lee SGdoi
10.1016/j.fitote.2010.07.015subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1134-41issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00192-9journal_volume
81pub_type
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