Abstract：
:Four new lathyrane-type diterpenoids (1-4) and a novel macrocyclic diterpenoid (5) featuring a 5/7/7/4-fused ring system, together with seventeen known ones (6-22), were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by extensive spectroscopic analyses and single crystal X-ray crystallography. These isolates were evaluated for their inhibition against nitric oxide (NO) production induced by lipopolysaccharide (LPS) in BV-2 microglial cells. As a result, the inhibitory rates of compounds 1, 3, 4, 6, 7, 9-11, 13-15, 20, and 21 on NO production were more than 40% with the cell viability more than 80% at their effective concentrations. In addition, compounds 6 and 11 markedly reduced the mRNA levels of pro-inflammatory cytokines IL-6 and IL-1β in LPS-stimulated BV-2 cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zuo Q,Mu HY,Gong Q,Ding X,Wang W,Zhang HY,Zhao WMdoi
10.1016/j.fitote.2021.104834subject
Has Abstractpub_date
2021-01-26 00:00:00pages
104834eissn
0367-326Xissn
1873-6971pii
S0367-326X(21)00009-5pub_type
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