Abstract:
:Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human cancer cell lines were assayed, and most interestingly, compound 10 revealed preferred cytotoxicity on the HT-1080 cell line and displayed much stronger inhibitory activity (IC50=8.86 μM) compared with positive control 5-fluorouracil (IC50=35.62 μM). Meanwhile, antioxidant activities of all the isolates were evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the results showed that most of the isolates exhibited potent antioxidant activity.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJdoi
10.1016/j.fitote.2013.09.011subject
Has Abstractpub_date
2013-12-01 00:00:00pages
217-223eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00246-3journal_volume
91pub_type
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