Abstract:
:Five new phthalides (1-4, 6), two new natural products (5, 7) and five known phthalides (8-12) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were established by the circular dichroism (CD) spectrum and the modified Mosher's method. Compounds 1-8 were tested against SK-N-SH cell depriving oxygen and glucose and showed different degrees of increasing the cell survival, among which compounds 1, 4 and 8 (10 μM) showed higher cell survival than Ginsenoside Rg1.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Wei Q,Yang J,Ren J,Wang A,Ji T,Su Ydoi
10.1016/j.fitote.2014.01.010subject
Has Abstractpub_date
2014-03-01 00:00:00pages
226-32eissn
0367-326Xissn
1873-6971pii
S0367-326X(14)00016-1journal_volume
93pub_type
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