Abstract：
:Five new cadinene-type sesquiterpenes, hibiscusterpenes I-V (1-5), and six known compounds (6-11) have been isolated from the methanol extract of the stems and the twigs of Hibiscus tiliaceus. The structures of the new compounds were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of hibiscusterpene I (1) was determined using X-ray crystallography. For hibiscusterpene III (3), the absolute configuration was established upon comparison of the experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, hibiscone C (7) and syriacusin A (11) showed cytotoxic activity in HeLa cells. In addition, their cell death-inducing activity was observed using time-lapse cell imaging.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Μatsumoto T,Imahori D,Achiwa K,Saito Y,Ohta T,Yoshida T,Kojima N,Yamashita M,Nakayama Y,Watanabe Tdoi
10.1016/j.fitote.2020.104524subject
Has Abstractpub_date
2020-04-01 00:00:00pages
104524eissn
0367-326Xissn
1873-6971pii
S0367-326X(20)30106-4journal_volume
142pub_type
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