Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum.

abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

journal_title：Fitoterapia

authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

更新日期：2015-06-01 00:00:00

abstract：:Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viabilit...

journal_title：Fitoterapia

authors： Zhang W,Zhang SY,Wang GY,Li NP,Chen MF,Gu JH,Zhang DM,Wang L,Ye WC

更新日期：2017-04-01 00:00:00

abstract：:Two prenylated isoflavanones (1) and (2) were isolated from the stem bark of Lespedeza bicolor along with the known compounds ethyl caffeate, caffeic acid, protocatechuic acid, betulinic acid, betulin, beta-sitosterol and from the stem heartwood daidzein and isoliquiritigenin. ...

journal_title：Fitoterapia

authors： Maximov OB,Kulesh NI,Stepanenko LS,Dmitrenok PS

更新日期：2004-01-01 00:00:00

abstract：:alpha(2)beta(1) and alpha(IIb)beta(3) integrins, that support platelet adhesion to collagen and fibrinogen, respectively, share common signaling molecules. The effect of quercetin on platelet static adhesion to collagen and fibrinogen was assessed and correlated with its kinase inhibitory activity. Quercetin strongly ...

journal_title：Fitoterapia

authors： Navarro-Núñez L,Lozano ML,Martínez C,Vicente V,Rivera J

更新日期：2010-03-01 00:00:00

abstract：:Aloe vera gel is a familiar ingredient in a range of widely available and advertisement healthcare and cosmetic products. As to date there are no documented reports on the standardization of A. vera gel and the following study is an attempt in this direction. A. vera gel was evaluated for its aloeverose content for th...

journal_title：Fitoterapia

authors： Lobo R,Prabhu KS,Shirwaikar A,Ballal M,Balachandran C,Shirwaikar A

更新日期：2010-06-01 00:00:00

abstract：:Diplacone (1) and mimulone (2), two geranylated flavanones, have previously shown anti-inflammatory and antiradical activity in vitro. The present study aimed to evaluate their activity in vivo on a model of colitis induced in Wistar rats by an oral administration of dextran sulfate sodium (DSS). Diplacone (1) and mim...

journal_title：Fitoterapia

authors： Vochyánová Z,Bartošová L,Bujdáková V,Fictum P,Husník R,Suchý P,Šmejkal K,Hošek J

更新日期：2015-03-01 00:00:00

abstract：:This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium channels of mammalian brain (IC(50)=23 µM) based on the ability of this substance to suppress t...

journal_title：Fitoterapia

authors： Nicholson RA,David LS,Pan RL,Liu XM

更新日期：2010-10-01 00:00:00

abstract：:Thirty-five crude extracts from 11 Panamanian plants, distributed in 10 genera and five families, were evaluated for their in vitro cytotoxicity. Four extracts exhibited an inhibition of cellular growth at IC(50) values lower than 25 microg/ml which was considered a significant activity. ...

journal_title：Fitoterapia

authors： Calderón AI,Terreaux C,Gupta MP,Hostettmann K

更新日期：2003-06-01 00:00:00

abstract：:The genus Cyclopia (Fabaceae family) includes a number of shrubs endemic to Cape Fynbos region of South Africa. The most common of these plants is Cyclopia intermedia E. Mey., used together with other Cyclopia species (mainly C. subternata and C. sessiliflora) to manufacture the honeybush herbal tea which has been pro...

journal_title：Fitoterapia

authors： Kokotkiewicz A,Luczkiewicz M

更新日期：2009-01-01 00:00:00

abstract：:Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their ¹H and ¹³C NMR spectra including two-dimensional NMR techniques...

journal_title：Fitoterapia

authors： Hussain J,Ur Rehman N,Hussain H,Al-Harrasi A,Ali L,Rizvi TS,Ahmad M,Mehjabeen

更新日期：2012-04-01 00:00:00

abstract：:8,2'-Diprenylquercetin 3-methyl ether, a natural product with prominent anti-breast cancer activity, is the main active constituent of Sinopodophylli Fructus. A high-performance liquid chromatography with a diode array detector coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (...

journal_title：Fitoterapia

authors： Ma LM,Xu F,Wang JZ,Shang MY,Liu GX,Cai SQ

更新日期：2019-09-01 00:00:00

abstract：:The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with m...

journal_title：Fitoterapia

authors： Djebara A,Ciavatta ML,Mathieu V,Colin M,Bitam F,Carbone M,Gavagnin M

更新日期：2019-10-01 00:00:00

abstract：:Five new cadinene-type sesquiterpenes, hibiscusterpenes I-V (1-5), and six known compounds (6-11) have been isolated from the methanol extract of the stems and the twigs of Hibiscus tiliaceus. The structures of the new compounds were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry...

journal_title：Fitoterapia

authors： Μatsumoto T,Imahori D,Achiwa K,Saito Y,Ohta T,Yoshida T,Kojima N,Yamashita M,Nakayama Y,Watanabe T

更新日期：2020-04-01 00:00:00

abstract：:Isorhynchophylline is one of the major alkaloids from the Uncaria hook possessing the effects of lowered blood pressure, vasodilatation and protection against ischemia-induced neuronal damage. However, the metabolic pathway of isorhynchophylline has not been fully reported yet. In this paper, the metabolism of isorhyn...

journal_title：Fitoterapia

authors： Chen F,Qi W,Sun J,Simpkins JW,Yuan D

更新日期：2014-09-01 00:00:00

abstract：:Five polyketides, paralactonic acids A-E (1-5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of com...

journal_title：Fitoterapia

authors： Suzuki T,Ariefta NR,Koseki T,Furuno H,Kwon E,Momma H,Harneti D,Maharani R,Supratman U,Kimura KI,Shiono Y

更新日期：2019-01-01 00:00:00

abstract：:In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures o...

journal_title：Fitoterapia

authors： Cao L,Li B,Shehla N,Gong LM,Jian YQ,Peng CY,Sheng WB,Liu LP,Cai X,Man RY,Liao DF,Zhu XQ,Choudhary MI,Rahman AU,Wang W

更新日期：2020-01-01 00:00:00

abstract：:Usually isolated from Garcinia (Clusiaceae) or Hypericum (Hypericaceae) species, some Polycyclic Polyprenylated AcylPhloroglucinols (PPAPs) have been recently reported as potential research tools for immunotherapy. Aiming at exploring the chemodiversity of PPAPs amongst Garcinia genus, a dereplication process suitable...

journal_title：Fitoterapia

authors： Bruguière A,Derbré S,Coste C,Le Bot M,Siegler B,Leong ST,Sulaiman SN,Awang K,Richomme P

更新日期：2018-11-01 00:00:00

abstract：:Phytochemical investigation on the stem bark of Toona sinensis was carried out by various chromatographic techniques resulting in the isolation and elucidation of two novel tirucallane triterpenoids, named (20S)-3-oxo-tirucalla-25-nor-7-en-24-oic acid (1) and (20S)-5α,8α-epidioxy-3-oxo-24-nor-6.9(11)-dien-23-oic acid ...

journal_title：Fitoterapia

authors： Tang J,Xu J,Zhang J,Liu WY,Xie N,Chen L,Feng F,Qu W

更新日期：2016-07-01 00:00:00

abstract：:Five new cytochalasans (1-5) were isolated from the rice fermentation of fungus Xylaria longipes, along with seven known compounds cytochalasin P (6), cytochalasin D (7), zygosporin D (8), 7-O-acetylcytochalasin D (9), cytochalasin C (10), 6,7-dihydro-7-oxo-cytochalasin C (11), and 6,7-dihydro-7-oxo-deacetylcytochalas...

journal_title：Fitoterapia

authors： Wang WX,Li ZH,He J,Feng T,Li J,Liu JK

更新日期：2019-09-01 00:00:00

abstract：:Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafr...

journal_title：Fitoterapia

authors： Hayashi K,Yamaguchi Y,Ogita A,Tanaka T,Kubo I,Fujita KI

更新日期：2018-07-01 00:00:00

abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...

journal_title：Fitoterapia

authors： Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

更新日期：2014-06-01 00:00:00

abstract：:In a two-microelectrode voltage clamp assay with Xenopus laevis oocytes, a petroleum ether extract (100 μg/mL) of the resin of Boswellia thurifera (Burseraceae) potentiated GABA-induced chloride currents (IGABA) through receptors of the subtype α₁β₂γ₂s by 319.8% ± 79.8%. With the aid of HPLC-based activity profiling, ...

journal_title：Fitoterapia

authors： Rueda DC,Raith M,De Mieri M,Schöffmann A,Hering S,Hamburger M

更新日期：2014-12-01 00:00:00

abstract：:Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative...

journal_title：Fitoterapia

authors： Kedzierska M,Olas B,Wachowicz B,Glowacki R,Bald E,Czernek U,Szydłowska-Pazera K,Potemski P,Piekarski J,Jeziorski A

更新日期：2012-03-01 00:00:00

abstract：:The isolation of 14 known triterpenoids and phytosterols from the trunk bark of Maquira coriacea, and complete spectral data of a cardenolide, k-strophanthin-beta (1), are reported. ...

journal_title：Fitoterapia

authors： Mitaine-Offer AC,Sauvain M,Petermann C,Zèches-Hanrot M

更新日期：2001-11-01 00:00:00

abstract：:A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6α-hydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds...

journal_title：Fitoterapia

authors： Liu YC,Su J,Wu XD,Zhang ZJ,Fan M,Zhu QF,He J,Li XN,Peng LY,Cheng X,Zhao QS

更新日期：2016-12-01 00:00:00

abstract：:A new sesquiterpene lactone, 7alpha,10alpha-epoxy-1alpha(H),5alpha(H)-guaia-3,11(13)-dien-8alpha,12-olide, was isolated from the leaves of Hedyosmum arborescens. The structure of this unusual 7,10-epoxy-guaianolide was determined by spectroscopic methods, particularly one- and two-dimensional 1H and 13C NMR. ...

journal_title：Fitoterapia

authors： Bercion S,Couppe de K Martin MA,Baltaze JP,Bourgeois P

更新日期：2005-12-01 00:00:00

abstract：:Bioassay-guided fractionation of the dichloromethane extract of the fungus Neofusicoccum austral SYSU-SKS024 led to the isolation of three new ethylnaphthoquinone derivatives, neofusnaphthoquinone A (1), 6-(1-methoxylethy1)-2,7-dimethoxyjuglone (2), (3R,4R)-3-methoxyl-botryosphaerone D (6), together with six known ana...

journal_title：Fitoterapia

authors： Cui H,Zhang H,Liu Y,Gu Q,Xu J,Huang X,She Z

更新日期：2018-03-01 00:00:00

abstract：:The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitonea...

journal_title：Fitoterapia

authors： Amos S,Binda L,Akah P,Wambebe C,Gamaniel K

更新日期：2003-02-01 00:00:00

abstract：:Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Polyozellin, a major constituent of a Korea edible mushroo...

journal_title：Fitoterapia

authors： Lee W,Yang EJ,Park DH,Bae JS

更新日期：2016-01-01 00:00:00

abstract：:Oral treatment with the water extracts of Scoparia dulcis whole aerial parts, at doses of 50, 100 and 200 mg/kg, dose dependently inhibited the indomethacin-induced gastric damages in rats. ...

journal_title：Fitoterapia

authors： Babincová M,Schronerová K,Sourivong P

更新日期：2008-12-01 00:00:00