Abstract:
:Five new cytochalasans (1-5) were isolated from the rice fermentation of fungus Xylaria longipes, along with seven known compounds cytochalasin P (6), cytochalasin D (7), zygosporin D (8), 7-O-acetylcytochalasin D (9), cytochalasin C (10), 6,7-dihydro-7-oxo-cytochalasin C (11), and 6,7-dihydro-7-oxo-deacetylcytochalasin C (12). Their structures and absolute configurations were determined by extensive experimental spectroscopic methods as well as ECD calculation and GIAO 13C NMR calculation. The cytotoxicity of obtained compounds (1-12) was evaluated against human cancer cell lines HL-60, A549, SMMC-7721, MCF-7, and SW480. Compounds 6-8, 11, and 12 showed cytotoxicity with IC50 value ranging from 4.17-37.18 μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Wang WX,Li ZH,He J,Feng T,Li J,Liu JKdoi
10.1016/j.fitote.2019.104278subject
Has Abstractpub_date
2019-09-01 00:00:00pages
104278eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)31346-2journal_volume
137pub_type
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