Abstract:
:Two new bisbibenzyls, heudelotol A (1) and B (2), along with the known bibenzyls, (E)-combretastatin A-1 (3) and combretastatin B-1 (4) have been isolated from the ethyl acetate extract of the roots of Dichapetalum heudelotii. Structure elucidation of all four isolated compounds was achieved using UV, IR, 1D and 2D NMR spectroscopy and HR-Mass Spectrometry. The compounds exhibited varying antiproliferative activity against six cancer cell lines using the CellTiter-Glo® Luminiscent Cell Viability Assay. Compound 3 was found to be the most active with sub-micromolar growth inhibition concentrations against all the cell lines (GI50 0.03-0.72μM). However, it was about ten-fold less active than the positive control, taxol. The new bisbibenzyls heudelotol A and B exhibited good activity against human pancreatic adenocarcinoma (GI50 9.04μM) and Burkitt's lymphoma (GI50 4.67μM) respectively, and average activity against the other cancer cell lines.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Osei-Safo D,Dziwornu GA,Salgado A,Sunassee SN,Chama MAdoi
10.1016/j.fitote.2017.09.001subject
Has Abstractpub_date
2017-10-01 00:00:00pages
95-100eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31096-1journal_volume
122pub_type
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