Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities.

Abstract:

:Two new bisbibenzyls, heudelotol A (1) and B (2), along with the known bibenzyls, (E)-combretastatin A-1 (3) and combretastatin B-1 (4) have been isolated from the ethyl acetate extract of the roots of Dichapetalum heudelotii. Structure elucidation of all four isolated compounds was achieved using UV, IR, 1D and 2D NMR spectroscopy and HR-Mass Spectrometry. The compounds exhibited varying antiproliferative activity against six cancer cell lines using the CellTiter-Glo® Luminiscent Cell Viability Assay. Compound 3 was found to be the most active with sub-micromolar growth inhibition concentrations against all the cell lines (GI50 0.03-0.72μM). However, it was about ten-fold less active than the positive control, taxol. The new bisbibenzyls heudelotol A and B exhibited good activity against human pancreatic adenocarcinoma (GI50 9.04μM) and Burkitt's lymphoma (GI50 4.67μM) respectively, and average activity against the other cancer cell lines.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Osei-Safo D,Dziwornu GA,Salgado A,Sunassee SN,Chama MA

doi

10.1016/j.fitote.2017.09.001

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

95-100

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(17)31096-1

journal_volume

122

pub_type

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