Abstract：
:There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to angiogenesis. To test this hypothesis, we investigated the angiogenic effects of motherwort total alkaloids and essential oil, as well as their respective primary components, on zebrafish embryos. Motherwort total alkaloids significantly increased angiogenesis in transgenic Tg (flk1: EGFP) zebrafish embryos treated with sunitinib, as did stachydrine, the most abundant alkaloid produced by motherwort. Unexpectedly, motherwort essential oil was toxic to zebrafish embryos. Our results indicated, for the first time, that motherwort alkaloids were potent angiogenic agents, while even low concentrations of motherwort essential oil were toxic. As angiogenesis is a critical aspect of postpartum recovery, our results provide evidence for traditional application of motherwort water decoction and its Chinese patent medicines (e.g. motherwort injection) to promote postpartum recovery.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
He YL,Shi JY,Peng C,Hu LJ,Liu J,Zhou QM,Guo L,Xiong Ldoi
10.1016/j.fitote.2018.05.002subject
Has Abstractpub_date
2018-07-01 00:00:00pages
36-42eissn
0367-326Xissn
1873-6971pii
S0367-326X(18)30521-5journal_volume
128pub_type
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