Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids.

abstract：:Tunicyclin L (1), cyclo (L-Pro1-Gly-L-Phe1-L-Ile-L-Pro2-L-Phe2 -L-Thr-L-Val), and 11 known compounds, including one cyclic peptide (2), eight carboline alkaloids (3 -10), one lignan (11) and one flavone (12) were isolated from the roots of Psammosilene tunicoides. Their structures were elucidated on the basis of exten...

journal_title：Fitoterapia

authors： Hou Y,Wang M,Sun C,Peng C,Zhang Y,Li X

更新日期：2020-09-01 00:00:00

abstract：:Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4-6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, I...

journal_title：Fitoterapia

authors： Liu D,Liu YW,Guan FQ,Liang JY

更新日期：2014-07-01 00:00:00

abstract：:Caesalpinone A (1), a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, along with ten known sesquiterpenoids (2-11) were isolated from the pods of Caesalpinia spinosa Kuntze (Tara). The structure of caesalpinone A was elucidated based on its 1D and 2D NMR spectra. The absolute configurati...

journal_title：Fitoterapia

authors： Mu W,Tang H,Li Y,He D,Ma R,Wang L

更新日期：2016-07-01 00:00:00

abstract：:Two new guaiane-type sesquiterpenoids containing an interesting epoxy unit, daucuside (1) and daucusol (2) were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation and they were also evaluated for the cy...

journal_title：Fitoterapia

authors： Fu HW,Zhang L,Yi T,Feng YL,Tian JK

更新日期：2010-07-01 00:00:00

abstract：:Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from Viola ignobilis. In the present study, we examined the effects of vigno 5, a natu...

journal_title：Fitoterapia

authors： Esmaeili MA,Abagheri-Mahabadi N,Hashempour H,Farhadpour M,Gruber CW,Ghassempour A

更新日期：2016-03-01 00:00:00

abstract：:Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction in aqueous solution, Sal B (200 mg) was decocted in an aqueous ...

journal_title：Fitoterapia

authors： Lee HJ,Cho JY,Moon JH

更新日期：2012-10-01 00:00:00

abstract：:The composition of the essential oil of Lindera neesiana Kurz fruit was examined by GC-MS, (1)H, (13)C and bidimensional NMR techniques (HMQC, HMBC, COSY, TOCSY). Forty compounds were identified, representing approximately 86% of the oil: Z-citral (15.08%), E-citral (11.89%), eucalyptol (8.75%), citronellal (6.72%), a...

journal_title：Fitoterapia

authors： Comai S,Dall'Acqua S,Grillo A,Castagliuolo I,Gurung K,Innocenti G

更新日期：2010-01-01 00:00:00

abstract：:To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 ...

journal_title：Fitoterapia

authors： Mvondo MA,Njamen D,Fomum ST,Wandji J,Vollmer G

更新日期：2011-10-01 00:00:00

abstract：:Malaria is one of the most devastating infectious diseases in the developing world. Until now, only one candidate malaria vaccine RTS,S/AS01 has shown modest protection in phase 3 trial in African infants. Hence the treatment of malaria still depends on the current chemotherapeutic drugs. Considering the resistance of...

journal_title：Fitoterapia

authors： Jin H,Xu Z,Cui K,Zhang T,Lu W,Huang J

更新日期：2014-04-01 00:00:00

abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

journal_title：Fitoterapia

authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

更新日期：2020-03-01 00:00:00

abstract：:Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of...

journal_title：Fitoterapia

authors： Zhao DK,Ai HL,Zi SH,Zhang LM,Yang SC,Guo HC,Shen Y,Chen YP,Chen JJ

更新日期：2013-12-01 00:00:00

abstract：:The essential oil from the aerial parts of Seseli annuum, wild-growing in Serbia, was obtained by hydrodistillation and analyzed using GC and GC/MS. A total of 43 components were identified representing 96.5% of S. annuum oil. The most abundant compounds were germacrene D (29.8%), sabinene (10.3%), beta-ocimene Z (9.8...

journal_title：Fitoterapia

authors： Milosavljević S,Tesević V,Vucković I,Jadranin M,Vajs V,Soković M,Janaćković P,Jovanović A

更新日期：2007-06-01 00:00:00

abstract：:Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluat...

journal_title：Fitoterapia

authors： Sukandar ER,Ersam T,Fatmawati S,Siripong P,Aree T,Tip-pyang S

更新日期：2016-01-01 00:00:00

abstract：:The antimicrobial activity of ethanol, acetone and aqueous extracts of the aerial parts of Pseudognaphalium moritzianum was evaluated. Ethanol and acetone extracts showed activity against Staphlococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa. The aqueous extract was active against S. aureus and P. aer...

journal_title：Fitoterapia

authors： Rangel D,Garcia I,Velasco J,Buitrago D,Velazco E

更新日期：2002-12-01 00:00:00

abstract：:A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cerv...

journal_title：Fitoterapia

authors： Dat NT,Binh PT,Quynh le TP,Van Minh C,Huong HT,Lee JJ

更新日期：2010-12-01 00:00:00

abstract：:Six new flavonoids, seladoeflavones A-F (1-6), were isolated from the whole herbs of Selaginella doederleinii, together with one known flavonoid (7). Their structures including absolute configuration were characterized on the basis of extensive spectroscopic methods including NMR, HRMS, and electronic circular dichroi...

journal_title：Fitoterapia

authors： Zou Z,Xu K,Xu P,Li X,Cheng F,Li J,Yu X,Cao D,Li D,Zeng W,Zhang G,Tan G

更新日期：2017-01-01 00:00:00

abstract：:Four new sesquiterpenes (1-2, 6-7), a new pyranone glycoside (10) along with six known compounds, were isolated from the whole plant of Erigeron breviscapus. Their planar structures were elucidated using extensive spectroscopic analyses. Brevisterpene A (1) and brevisterpene B (2) were proved to be a pair of diastereo...

journal_title：Fitoterapia

authors： Han S,Liu Y,Hou Z,Sun X,Yao G,Gao P,Li L,Song S

更新日期：2019-10-01 00:00:00

abstract：:The antifungal activity of methanolic extract and alkaloidal fraction of Berberis aetnensis against Candida species was investigated. The crude extract was active against Candida species, this activity being higher than that of the alkaloidal fraction and berberine. ...

journal_title：Fitoterapia

authors： Iauk L,Costanzo R,Caccamo F,Rapisarda A,Musumeci R,Milazzo I,Blandino G

更新日期：2007-02-01 00:00:00

abstract：:Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means...

journal_title：Fitoterapia

authors： Kiss T,Orvos P,Bánsághi S,Forgo P,Jedlinszki N,Tálosi L,Hohmann J,Csupor D

更新日期：2013-10-01 00:00:00

abstract：:Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

journal_title：Fitoterapia

authors： Mitaku S,Fokialakis N,Magiatis P,Tillequin F

更新日期：2007-02-01 00:00:00

abstract：:The isolation of five flavonol glycosides (1-5) from the flowers of Aconitum vulparia is reported, together with the 1H- and 13C-NMR spectral data in CD(3)OD of compound 3 and 5. ...

journal_title：Fitoterapia

authors： Fico G,Braca A,Morelli I,Tomè F

更新日期：2003-06-01 00:00:00

abstract：:Euphorbia aellenii Rech. f. (Euphorbiaceae) afforded a cytotoxic chloroform fraction from which two new esters of 6(17)-epoxylathyrol were identified (1 and 2). The structure of these compounds was elucidated by spectroscopic methods. ...

journal_title：Fitoterapia

authors： Ayatollahi AM,Ghanadian M,Afsharypuor S,Choudhary MI,Kobarfard F,Rahmati M

更新日期：2010-10-01 00:00:00

abstract：:Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showe...

journal_title：Fitoterapia

authors： Kaennakam S,Siripong P,Tip-Pyang S

更新日期：2015-04-01 00:00:00

abstract：:Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...

journal_title：Fitoterapia

authors： Liu L,Li J,Zeng KW,Jiang Y,Tu PF

更新日期：2015-06-01 00:00:00

abstract：:Chemical investigation of the cultured polyspore-derived mycobionts of a Pseudopyrenula subnudata lichen led to the isolation of two new compounds, subnudatones A and B (1 and 2), together with four known compounds, 1-(2-hydroxy-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethanone (3), libertalide C (4)...

journal_title：Fitoterapia

authors： Duong TH,Nguyen HH,Le TT,Tran TN,Sichaem J,Nguyen TT,Nguyen TP,Mai DT,Nguyen HH,Le HD

更新日期：2020-04-01 00:00:00

abstract：:Since the extract from berries of Aronia melanocarpa presents antioxidative properties in plasma and in blood platelets, not only from healthy group, but also from patients with benign breast diseases and in patients with invasive breast cancer before surgery, the aim of our present study was to evaluate the oxidative...

journal_title：Fitoterapia

authors： Kedzierska M,Olas B,Wachowicz B,Glowacki R,Bald E,Czernek U,Szydłowska-Pazera K,Potemski P,Piekarski J,Jeziorski A

更新日期：2012-03-01 00:00:00

abstract：:Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic ...

journal_title：Fitoterapia

authors： Zhang R,He HP,Di YT,Li SL,Zuo GY,Zhang Y,Hao XJ

更新日期：2014-01-01 00:00:00

abstract：:Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...

journal_title：Fitoterapia

authors： Yao JN,Chen L,Chen HP,Zhao ZZ,Zhang SB,Huang Y,Tang Y,Isaka M,Li ZH,Feng T,Liu JK

更新日期：2018-03-01 00:00:00

abstract：:The purpose of this study was to determine the photoprotective properties of the methanolic extract of Buddleja scordioides, as well as verbascoside and linarin which were isolated from this extract, and linarin acetate prepared in the laboratory. The photoprotective effect of substances against UV-B induced cellular ...

journal_title：Fitoterapia

authors： Avila Acevedo JG,Castañeda CM,Benitez FJ,Durán DA,Barroso VR,Martínez CG,Muñoz LJ,Martínez CA,Romo de Vivar A

更新日期：2005-06-01 00:00:00

abstract：:Flos Chrysanthemi (the flower of Chrysanthemum morifolium Ramat.) is widely used in China as a food and traditional Chinese medicine for many diseases. Luteolin and apigenin are two main bioactive components in Flos Chrysanthemi, and chrysoeriol and diosmetin are two methylated metabolites of luteolin in vivo by cathe...

journal_title：Fitoterapia

authors： Chen Z,Kong S,Song F,Li L,Jiang H

更新日期：2012-12-01 00:00:00