Abstract:
:Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D-G (1-4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50>40 μM), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92(#) and MRSA98(#) (MIC>50 μg/mL).
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhang R,He HP,Di YT,Li SL,Zuo GY,Zhang Y,Hao XJdoi
10.1016/j.fitote.2013.10.014subject
Has Abstractpub_date
2014-01-01 00:00:00pages
100-4eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00291-8journal_volume
92pub_type
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