Chemical constituents from Aphanamixis grandifolia.

Abstract:

:Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D-G (1-4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50>40 μM), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92(#) and MRSA98(#) (MIC>50 μg/mL).

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhang R,He HP,Di YT,Li SL,Zuo GY,Zhang Y,Hao XJ

doi

10.1016/j.fitote.2013.10.014

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

100-4

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(13)00291-8

journal_volume

92

pub_type

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