Abstract：
:Alkaloids comprise one of the largest groups of plant secondary metabolites including vinca alkaloids. The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied. Flow-cytometry in a multidrug-resistant human MDR1-gene-transfected mouse lymphoma cells (L5178Y) was applied. The inhibition of multidrug resistance was investigated by measuring the accumulation of rhodamine-123 in cancer cells. Veralosinine and veranigrine were the most effective resistance modifiers. In a checkerboard method veralosinine and veranigrine enhanced the antiproliferative effects of doxorubicin on MDR cells in combination. The structure-activity relationships were discussed.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Ivanova A,Serly J,Christov V,Stamboliyska B,Molnar Jdoi
10.1016/j.fitote.2011.01.015subject
Has Abstractpub_date
2011-06-01 00:00:00pages
570-5issue
4eissn
0367-326Xissn
1873-6971pii
S0367-326X(11)00036-0journal_volume
82pub_type
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