Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction.

Abstract:

:The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure. Heart failure was induced by left coronary artery occlusion and verified using echocardiography. Cyclovirobuxine D was administered for 30 days (0.5, 1.0 and 2.0mg/kg, ig) and mortality, cardiac function, hemodynamics, microcirculation, histology and ultrastructure assessments were observed. Results from the present study suggest that Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction and supports the potential for Cyclovirobuxine D as a new therapy for heart failure.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Yu B,Fang TH,Lü GH,Xu HQ,Lu JF

doi

10.1016/j.fitote.2011.04.016

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

868-77

issue

6

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(11)00115-8

journal_volume

82

pub_type

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