Immunopharmacological properties of flavonoids.

abstract：:The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screen...

journal_title：Fitoterapia

authors： Lutz JA,Kulshrestha M,Rogers DT,Littleton JM

更新日期：2014-10-01 00:00:00

abstract：:A new arylnaphthalene lignan, named furfuracin, was isolated from the leaves of Knema furfuracea (Myristicaceae), whereas 7 known compounds including (+)-trans-1,2-dihydrodehydroguaiaretic acid, fragransin A(2), biochanin A, gingkolic acid, anarcardic acid, 2-hydroxy-6-(12-phenyldodecyl)-benzoic acid and 2-hydroxy-6-(...

journal_title：Fitoterapia

authors： Rangkaew N,Suttisri R,Moriyasu M,Kawanishi K

更新日期：2009-09-01 00:00:00

abstract：:Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafr...

journal_title：Fitoterapia

authors： Hayashi K,Yamaguchi Y,Ogita A,Tanaka T,Kubo I,Fujita KI

更新日期：2018-07-01 00:00:00

abstract：:Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were ...

journal_title：Fitoterapia

authors： Yuan CM,Tang GH,Wang XY,Zhang Y,Cao MM,Li XH,Li Y,Li SL,Di YT,He HP,Hao XJ,Hua HM

更新日期：2013-10-01 00:00:00

abstract：:Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

journal_title：Fitoterapia

authors： Ye Y,Guo Y,Luo YT,Wang YF

更新日期：2012-12-01 00:00:00

abstract：:The ethanolic extracts of Lawsonia inermis leaves, Holarrhena antidysenterica bark, Swertia chirata whole plant and Mangifera indica bark were tested (in-vitro) for alpha-glucosidase inhibitory activity. M. indica extract was found to be the most potent, with an IC(50) value of 314 microg/ml. ...

journal_title：Fitoterapia

authors： Prashanth D,Amit A,Samiulla DS,Asha MK,Padmaja R

更新日期：2001-08-01 00:00:00

abstract：:A pair of diastereoisomers, the N-glycosylated derivatives of dioxindole-3-hydroxy-3-acetic acid 1-2, and their conjugates with flavonoids 3-8, was isolated from the seeds of Ziziphus jujuba var. spinosa. Their structures were elucidated by NMR spectroscopic analyses, and the absolute configurations were determined by...

journal_title：Fitoterapia

authors： Li M,Wang Y,Tsoi B,Jin XJ,He RR,Yao XJ,Dai Y,Kurihara H,Yao XS

更新日期：2014-12-01 00:00:00

abstract：:The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in...

journal_title：Fitoterapia

authors： Mayer B,Baggio CH,Freitas CS,dos Santos AC,Twardowschy A,Horst H,Pizzolatti MG,Micke GA,Heller M,dos Santos EP,Otuki MF,Marques MC

更新日期：2009-10-01 00:00:00

abstract：:A series of novel myricetin derivatives containing benzimidazole skeleton were constructed. The structure of compound 4g was further corroborated via X-ray single crystal diffractometer. The antimicrobial bioassays showed that all compounds exhibited potent inhibitory activities against Xanthomonas axonopodis pv. Citr...

journal_title：Fitoterapia

authors： Chen M,Tang X,Liu T,Peng F,Zhou Q,Luo H,He M,Xue W

更新日期：2020-12-11 00:00:00

abstract：:Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Polyozellin, a major constituent of a Korea edible mushroo...

journal_title：Fitoterapia

authors： Lee W,Yang EJ,Park DH,Bae JS

更新日期：2016-01-01 00:00:00

abstract：:Ethanolic extract of Rungia repens aerials parts (300 and 600 mg/kg p.o) showed diuretic activity in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg. ...

journal_title：Fitoterapia

authors： Basu SK,Arivukkarasu R

更新日期：2006-02-01 00:00:00

abstract：:Oplopanax horridus or devil's club is a herbal medicine distributed in North America. The constituents and pharmacological activities of O. horridus (OPH) are largely unknown. In this study, we assayed OPH stem and berry extracts using high performance liquid chromatography (HPLC). The anticancer potentials of extract...

journal_title：Fitoterapia

authors： Wang CZ,Aung HH,Mehendale SR,Shoyama Y,Yuan CS

更新日期：2010-03-01 00:00:00

abstract：:Cajaninstilbene acid (CSA), a bioactive constituent isolated from pigeon pea leaves, exhibited neuroprotective activities in previous studies. The present study aims to evaluate the antidepressant effects of CSA by using behavioral despair models of tail suspension test (TST) and forced swimming test (FST), and a chro...

journal_title：Fitoterapia

authors： Zhang MD,Tao X,Pan RL,Wang LS,Li CC,Zhou YF,Liao YH,Chen SG,Chang Q,Liu XM

更新日期：2020-03-01 00:00:00

abstract：:Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viabilit...

journal_title：Fitoterapia

authors： Zhang W,Zhang SY,Wang GY,Li NP,Chen MF,Gu JH,Zhang DM,Wang L,Ye WC

更新日期：2017-04-01 00:00:00

abstract：:Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type c...

journal_title：Fitoterapia

authors： Zhang Y,Cao Y,Wang Q,Zheng L,Zhang J,He L

更新日期：2011-10-01 00:00:00

abstract：:The purpose of this investigation was to study the modulator and efflux pump inhibitor activity of coumarins isolated from Mesua ferrea against clinical strains as well as NorA-over expressed strain of Staphylococcus aureus 1199B. Seven coumarins were tested for modulator activity using ethidium bromide (EtBr) as a su...

journal_title：Fitoterapia

authors： Roy SK,Kumari N,Pahwa S,Agrahari UC,Bhutani KK,Jachak SM,Nandanwar H

更新日期：2013-10-01 00:00:00

abstract：:8,2'-Diprenylquercetin 3-methyl ether, a natural product with prominent anti-breast cancer activity, is the main active constituent of Sinopodophylli Fructus. A high-performance liquid chromatography with a diode array detector coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (...

journal_title：Fitoterapia

authors： Ma LM,Xu F,Wang JZ,Shang MY,Liu GX,Cai SQ

更新日期：2019-09-01 00:00:00

abstract：:Five new aromatic compounds, designed as lucidumins A-D (1-4) and lucidimine E (9), along with seven known aromatic compounds (5-8, 10-12) were isolated from Ganoderma lucidum. Their structures were determined by spectroscopic method. Bioactive evaluation showed that compounds 2-4 and 6-10 displayed remarkable neuropr...

journal_title：Fitoterapia

authors： Lu SY,Peng XR,Dong JR,Yan H,Kong QH,Shi QQ,Li DS,Zhou L,Li ZR,Qiu MH

更新日期：2019-04-01 00:00:00

abstract：:Chemical investigation of the n-butanol extract from the methanol extract of the root bark of Artocarpus nobilis furnished four new prenylated flavonoids together with artonin E 2'-methylether (4), isoartonin E 2'-methylether (5), dihydroisoartonin E 2'-methylether (6), artonin V 2'-methylether (7), artobiloxanthone (...

journal_title：Fitoterapia

authors： Jayasinghe UL,Samarakoon TB,Kumarihamy BM,Hara N,Fujimoto Y

更新日期：2008-01-01 00:00:00

abstract：:Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...

journal_title：Fitoterapia

authors： Sequeiros C,López LM,Caffini NO,Natalucci CL

更新日期：2003-09-01 00:00:00

abstract：:A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis,...

journal_title：Fitoterapia

authors： de Novais LMR,de Arueira CCO,Ferreira LF,Ribeiro TAN,Sousa PT Jr,Jacinto MJ,de Carvalho MG,Judice WAS,Jesus LOP,de Souza AA,Torquato HFV,Paredes-Gamero EJ,Silva VC

更新日期：2019-01-01 00:00:00

abstract：:This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antim...

journal_title：Fitoterapia

authors： Tirillini B

更新日期：2000-08-01 00:00:00

abstract：:Oral treatment with the water extracts of Scoparia dulcis whole aerial parts, at doses of 50, 100 and 200 mg/kg, dose dependently inhibited the indomethacin-induced gastric damages in rats. ...

journal_title：Fitoterapia

authors： Babincová M,Schronerová K,Sourivong P

更新日期：2008-12-01 00:00:00

abstract：:Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes, is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and triacylglycerols) and the metabolism of xenobiotic esters (such as clopidogrel and oseltamivir), thus participates in physiological and pathological p...

journal_title：Fitoterapia

authors： Song PF,Zhu YD,Ma HY,Wang YN,Wang DD,Zou LW,Ge GB,Yang L

更新日期：2019-09-01 00:00:00

abstract：:A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 ...

journal_title：Fitoterapia

authors： Li L,Deng X,Zhang L,Shu P,Qin M

更新日期：2011-06-01 00:00:00

abstract：:Dichloromethane extract of propolis (DCME) originating from Pitcairn Island demonstrated potent cytotoxicity against triple-negative MDA-MB-231 human breast carcinoma cells. The results from MTT assay showed that DCME inhibits the growth of the cancer cells in a dose- and time-dependent manner and upon the cell growth...

journal_title：Fitoterapia

authors： Georgieva K,Trusheva B,Uzunova V,Stoyanova T,Valcheva V,Popova M,Tzoneva R,Bankova V

更新日期：2018-07-01 00:00:00

abstract：:Ailanthone (AIL) has many biological activities including antimalarial, antiviral and anticancer. Our previous study also found that AIL targets p23 against castration-resistant prostate cancer. In this report, the preclinical safety of AIL was evaluated by acute toxicity, subacute toxicity and toxicokinetics in mice....

journal_title：Fitoterapia

authors： Tang S,Ma X,Lu J,Zhang Y,Liu M,Wang X

更新日期：2019-07-01 00:00:00

abstract：:The aerial parts of the endemic Australian plant Eremophila debilis (Myoporaceae) contain 3% dry weight of the biologically active 5,6,7,3',4',5'-hexamethoxyflavone, which had its structured confirmed using X-ray crystal crystallography. The presence of significant levels of the polypharmacologically active 5,6,7,3',4...

journal_title：Fitoterapia

authors： Butler MS,Healy PC,Forster PI,Guymer GP,Quinn RJ

更新日期：2018-04-01 00:00:00

abstract：:The present study investigated the effects of isopulegol, a monoterpene alcohol, in PTZ-induced convulsions and verified possible involved mechanisms. Saline, isopulegol or diazepam were intraperitonealy injected 30 min before PTZ. The latency for development of convulsions and mortality, as well as the mortality prot...

journal_title：Fitoterapia

authors： Silva MI,Silva MA,de Aquino Neto MR,Moura BA,de Sousa HL,de Lavor EP,de Vasconcelos PF,Macêdo DS,de Sousa DP,Vasconcelos SM,de Sousa FC

更新日期：2009-12-01 00:00:00

abstract：:Three new cycloartane triterpenoids (1-3) and two known compounds (4, 5) were isolated from the whole plant of Beesia calthaefolia. Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All isolates were investigated for their inhibitory effects on the classical pathway of the ...

journal_title：Fitoterapia

authors： Mu LH,Li HJ,Guo DH,Zhao JY,Liu P

更新日期：2014-01-01 00:00:00