Cycloartane triterpenes from Beesia calthaefolia (Maxim.).

Abstract:

:Three new cycloartane triterpenoids (1-3) and two known compounds (4, 5) were isolated from the whole plant of Beesia calthaefolia. Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 4 showed stronger inhibitory activity (IC50 136.7 μM) than positive control (Rosmarinic acid, IC50 181.8 μM) while compounds 2 and 3 were moderately active with IC50 value of 206 μM and 200.9 μM. Chemical compound studied in this article: Rosmarinic acid (PubChem CID: 5281792).

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Mu LH,Li HJ,Guo DH,Zhao JY,Liu P

doi

10.1016/j.fitote.2013.10.005

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

41-5

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(13)00270-0

journal_volume

92

pub_type

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