Abstract:
:Three new cycloartane triterpenoids (1-3) and two known compounds (4, 5) were isolated from the whole plant of Beesia calthaefolia. Their structures were elucidated by 1D and 2D NMR, HRESIMS and optical rotation spectral data. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 4 showed stronger inhibitory activity (IC50 136.7 μM) than positive control (Rosmarinic acid, IC50 181.8 μM) while compounds 2 and 3 were moderately active with IC50 value of 206 μM and 200.9 μM. Chemical compound studied in this article: Rosmarinic acid (PubChem CID: 5281792).
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Mu LH,Li HJ,Guo DH,Zhao JY,Liu Pdoi
10.1016/j.fitote.2013.10.005subject
Has Abstractpub_date
2014-01-01 00:00:00pages
41-5eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00270-0journal_volume
92pub_type
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