Lignans from Strophanthus gratus.

abstract：:The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with m...

journal_title：Fitoterapia

authors： Djebara A,Ciavatta ML,Mathieu V,Colin M,Bitam F,Carbone M,Gavagnin M

更新日期：2019-10-01 00:00:00

abstract：:A pair of diastereoisomers, the N-glycosylated derivatives of dioxindole-3-hydroxy-3-acetic acid 1-2, and their conjugates with flavonoids 3-8, was isolated from the seeds of Ziziphus jujuba var. spinosa. Their structures were elucidated by NMR spectroscopic analyses, and the absolute configurations were determined by...

journal_title：Fitoterapia

authors： Li M,Wang Y,Tsoi B,Jin XJ,He RR,Yao XJ,Dai Y,Kurihara H,Yao XS

更新日期：2014-12-01 00:00:00

abstract：:A new steroidal alkaloid, (-)-veranigrine (1) was isolated from the roots and rhizomes of Veratrum nigrum L. By means of spectroscopic methods its structure was established as (20S, 25S)-iminocholesta-5,22(N)-diene-1beta,3beta-diol. ...

journal_title：Fitoterapia

authors： Christov V,Mikhova B,Selenge D

更新日期：2009-01-01 00:00:00

abstract：:Three new secoiridoids, swermacrolactones A-C (1-3), together with fourteen known compounds were isolated from Swertia macrosperma. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, MS, 1D and 2D NMR). By anti-HBV assay on the Hep G 2.2.15 cell line in vitro, the most active compound,...

journal_title：Fitoterapia

authors： Wang HL,Geng CA,Ma YB,Zhang XM,Chen JJ

更新日期：2013-09-01 00:00:00

abstract：:Australian native plants have a long history of therapeutic use in indigenous cultures, however, they have been poorly studied scientifically. We analysed the effects of 14 plant derived compounds from the species Pilidiostigma glabrum, Myoporum montanum, Geijera parviflora, and Rhodomyrtus psidioides for their potent...

journal_title：Fitoterapia

authors： Adams DH,Shou Q,Wohlmuth H,Cowin AJ

更新日期：2016-03-01 00:00:00

abstract：:The therapeutic uses and methods of administration of 70 plants in the traditional medicine of Sarrabus (south-east Sardinia, Italy) are documented. Among these species, some were not reported previously for Sardinia, while others turn out to have an original therapeutic use. ...

journal_title：Fitoterapia

authors： Palmese MT,Uncini Manganelli RE,Tomei PE

更新日期：2001-08-01 00:00:00

abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

journal_title：Fitoterapia

authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

更新日期：2015-06-01 00:00:00

abstract：:Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute c...

journal_title：Fitoterapia

authors： Li JL,Huang L,Liu J,Song Y,Gao J,Jung JH,Liu Y,Chen G

更新日期：2015-04-01 00:00:00

abstract：:7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1). With the chiral HPLC technology, (-)-(S)-7-O-methylvariecolortide A (1a), (+)-(R)-7-O-methylvariecolortide ...

journal_title：Fitoterapia

authors： Chen GD,Bao YR,Huang YF,Hu D,Li XX,Guo LD,Li J,Yao XS,Gao H

更新日期：2014-01-01 00:00:00

abstract：:A new compound, 3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid (1), and two known triterpenoids lantanilic acid (2) and camaric acid (3) were isolated from the stem and leaves of Lantana cujabensis. Their structures were elucidated by spectroscopic methods. The ethanol extracts did not sho...

journal_title：Fitoterapia

authors： Okunade AL,Lewis WH

更新日期：2004-06-01 00:00:00

abstract：:As part of our search for biologically active anti-osteoporotic agents that enhance the differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rd as the most active compound among ginsenosides. In this study, we showed that Rd stimulates osteoblastic differentiation and minera...

journal_title：Fitoterapia

authors： Kim DY,Park YG,Quan HY,Kim SJ,Jung MS,Chung SH

更新日期：2012-01-01 00:00:00

abstract：:Claims that Traditional/Alternative medicine (TM/AM) remedies are effective are routinely ignored by Western Medicine. However, the results of a clinical trial that demonstrated the clinical efficacy of Tripterygium wilfordii Hook F. (TW), a TM used as an anti-inflammatory, were recently published in the Annals of Int...

journal_title：Fitoterapia

authors： Marks WH

更新日期：2011-01-01 00:00:00

abstract：:Caper (Capparis L.), a shrub plant with a large natural distribution, is used in traditional medicines to cure various illnesses. Phytochemicals studies have shown the presence of many beneficial compounds such as spermidine, rutin, quercetin, kaempferol, stigmasterol, campesterol, tocopherols, and carotenoids. Biolog...

journal_title：Fitoterapia

authors： Tlili N,Elfalleh W,Saadaoui E,Khaldi A,Triki S,Nasri N

更新日期：2011-03-01 00:00:00

abstract：:A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpen...

journal_title：Fitoterapia

authors： Setzer WN,Shen X,Bates RB,Burns JR,McClure KJ,Zhang P,Moriarity DM,Lawton RO

更新日期：2000-04-01 00:00:00

abstract：:Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were det...

journal_title：Fitoterapia

authors： Wang JT,Zhang PL,Liu JS,Wang GK,Xu FQ,Chen L,Yu Y,Wang G

更新日期：2018-11-01 00:00:00

abstract：:In our previous study, RAPD (Random Amplified Polymorphic DNA) analysis revealed species-specific markers for three medicinal Echinacea species (Asteraceae): E. angustifolia DC., E. pallida (Nutt.) Nutt. and E. purpurea (L.) Moench. In the present work, we have converted a RAPD marker (750 bp) for E. purpurea into a S...

journal_title：Fitoterapia

authors： Adinolfi B,Chicca A,Martinotti E,Breschi MC,Nieri P

更新日期：2007-01-01 00:00:00

abstract：:The inhibitory activity of alpha-amylase and the phytochemical composition of Cedrus libani essential oils obtained from wood, leaves and cones were investigated. The C. libani woods oil exhibit an IC(50) value of 0.14 mg/ml, whereas the leaves and cones oils were devoid of any significant activity. ...

journal_title：Fitoterapia

authors： Loizzo MR,Saab AM,Statti GA,Menichini F

更新日期：2007-06-01 00:00:00

abstract：:The furanocoumarin imperatorin has been reported to have hypotensive effect, and we have investigated its activity on myocardial hypertrophy. Imperatorin displayed similar chromatographic retention peak to verapamil in the model of cardiac muscle/cell membrane chromatography, and could reduce in a concentration-depend...

journal_title：Fitoterapia

authors： Zhang Y,Cao Y,Zhan Y,Duan H,He L

更新日期：2010-12-01 00:00:00

abstract：:The aim of the present research was to establish a comprehensive strategy to identify the metabolites of isoimperatorin after biotransformation with rat liver microsomes in vitro, and further describe metabolic kinetic characteristics of isoimperatorin and its main metabolites. Utilizing liquid chromatography with tim...

journal_title：Fitoterapia

authors： Chen TL,Zhang YB,Xu W,Kang TG,Yang XW

更新日期：2014-03-01 00:00:00

abstract：:Seven oleanane-type triterpenoid saponins, tunicosaponins B-D (1-3), F-I (4-7), along with eight known triterpenoid saponins (8-15), were isolated from the roots of Psammosilene tunicoides. The structures of compounds 1-7 were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, mass...

journal_title：Fitoterapia

authors： Wen B,Tian JM,Huang ZR,Xiao SJ,Yuan WL,Wang JX,Li HL,Xu XK,Shen YH

更新日期：2020-07-01 00:00:00

abstract：:The isolation of cinchonicine-derived alkaloids epicinchonicinol (1), cinchonidicinol (2) and a mixture of dihydrocinchonicinol and dihydrocinchonidicinol (3) from the dried bark of Ladenbergia oblongifolia, is reported along with (1)H and (13)C-NMR data. ...

journal_title：Fitoterapia

authors： Okunade AL,Lewis WH,Elvin-Lewis MP,Casper SJ,Goldberg DE

更新日期：2001-08-01 00:00:00

abstract：AIM:The current study was designed to explore the mechanism of the prokinetic activity of Gentiopicroside (Ge), from Gentiana macrophylla Pall which is widely used to strengthen gastric motility in clinic. METHODS:Gastrointestinal motility disorder rats were induced by stress stimulation and the rats were treated with...

journal_title：Fitoterapia

authors： Ruan M,Yu B,Xu L,Zhang L,Long J,Shen X

更新日期：2015-06-01 00:00:00

abstract：:Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...

journal_title：Fitoterapia

authors： El Dib RA,Eskander J,Mohamed MA,Mohammed NM

更新日期：2015-10-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...

journal_title：Fitoterapia

authors： Li Q,Zhu Q,Zhang X,Hua C,Deng X,Zhao T,Sun B

更新日期：2013-10-01 00:00:00

abstract：:Rheum palmatum Linn has been widely applied in the clinical treatment of diabetes mellitus. It has been found that emodin as the major bioactive component of R. palmatum L exhibits the competency to activate peroxisomal proliferator-activated receptor-gamma (PPARgamma) in vitro. So the aim of this study was to evaluat...

journal_title：Fitoterapia

authors： Xue J,Ding W,Liu Y

更新日期：2010-04-01 00:00:00

abstract：:Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from t...

journal_title：Fitoterapia

authors： Abdullah N,Sahibul-Anwar H,Ideris S,Hasuda T,Hitotsuyanagi Y,Takeya K,Diederich M,Choo C

更新日期：2013-07-01 00:00:00

abstract：:The flavonoids are a heterogeneous group of ubiquitous plant polyphenols that abound in the human diet and are endowed with several biological activities, including immunomodulating and antioxidant activities. The bioactivity of flavonoids is tightly correlated with their chemical structure and action mechanisms, most...

journal_title：Fitoterapia

authors： Ielpo MT,Basile A,Miranda R,Moscatiello V,Nappo C,Sorbo S,Laghi E,Ricciardi MM,Ricciardi L,Vuotto ML

更新日期：2000-08-01 00:00:00

abstract：:8,2'-Diprenylquercetin 3-methyl ether, a natural product with prominent anti-breast cancer activity, is the main active constituent of Sinopodophylli Fructus. A high-performance liquid chromatography with a diode array detector coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (...

journal_title：Fitoterapia

authors： Ma LM,Xu F,Wang JZ,Shang MY,Liu GX,Cai SQ

更新日期：2019-09-01 00:00:00

abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

journal_title：Fitoterapia

authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

更新日期：2020-03-01 00:00:00

abstract：:Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflamma...

journal_title：Fitoterapia

authors： Wu ZL,Wang JX,Chen LP,Dong HY,Li HL,Zhang WD

更新日期：2018-03-01 00:00:00