Abstract:
:Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute configurations were assigned by CD calculations. The acetylcholinesterase (AchE) inhibitory activity of compounds 1 and 2 was evaluated, both of which showed moderate activity with IC50 values of 11.8 and 13.5μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Li JL,Huang L,Liu J,Song Y,Gao J,Jung JH,Liu Y,Chen Gdoi
10.1016/j.fitote.2015.01.014subject
Has Abstractpub_date
2015-04-01 00:00:00pages
203-7eissn
0367-326Xissn
1873-6971pii
S0367-326X(15)00025-8journal_volume
102pub_type
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